Recombinant Human/Mouse Wnt-5a Protein
R&D Systems, Inc. a Bio-Techne Brand
Key Product Details
Source: | CHO |
Accession #: | P22725 |
Applications: | Bioactivity |
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Citations for Recombinant Human/Mouse Wnt-5a Protein (165)
Citations are publications that use Bio-Techne products. Selected citations for Recombinant Human/Mouse Wnt-5a Protein include:
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Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay(2102), Ror family receptor tyrosine kinases regulate the maintenance of neural progenitor cells in the developing neocortex. J. Cell. Sci., 125(0):2017-29.
PMID: 22328498 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayM Ashry et al. (2022), FSH stimulated bovine granulosa cell steroidogenesis involves both canonical and noncanonical WNT signaling Domestic animal endocrinology, 78(0):106678.
PMID: 34607220 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayZ Dehghani-G et al. (2022), Wnt5A and TGFbeta1 Converges through YAP1 Activity and Integrin Alpha v Up-Regulation Promoting Epithelial to Mesenchymal Transition in Ovarian Cancer Cells and Mesothelial Cell Activation Cells, 11(2).
PMID: 35053353 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayY Zhao et al. (2022), Cadmium exposure reprograms energy metabolism of hematopoietic stem cells to promote myelopoiesis at the expense of lymphopoiesis in mice Oncogene, 231(0):113208.
PMID: 35051759 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureEM Ghia et al. (2022), High expression level of ROR1 and ROR1-signaling associates with venetoclax resistance in chronic lymphocytic leukemia Leukemia, 0(0).
PMID: 35418613 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayCJ Brereton et al. (2022), Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis Elife, 11(0).
PMID: 35188460 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureC Kornsuthis et al. (2022), Non-canonical Wnt signaling participates in Jagged1-induced osteo/odontogenic differentiation in human dental pulp stem cells Scientific Reports, 12(1):7583.
PMID: 35534526 -
Species: Mouse
Sample Types: Whole Cells
Applications: Cell CultureX Xue et al. (2022), Transient and Prolonged Activation of Wnt Signaling Contribute Oppositely to the Pathogenesis of Asherman's Syndrome International Journal of Molecular Sciences, 23(15).
PMID: 35955940 -
Species: Mouse
Sample Types: Whole Cells
Applications: DifferentiationN Salerno et al. (2022), Pharmacological clearance of senescent cells improves cardiac remodeling and function after myocardial infarction in female aged mice Mechanisms of Ageing and Development, 208(0):111740.
PMID: 36150603 -
Species: Porcine
Sample Types: Whole Cells
Applications: BioassayLJ Spicer et al. (2022), Hormone regulation of thrombospondin-1 mRNA in porcine granulosa cells in vitro Oncogene, 244(0):107048.
PMID: 35914333 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayKB Kim et al. (2022), WNT5A-RHOA signaling is a driver of tumorigenesis and represents a therapeutically actionable vulnerability in small cell lung cancer Cancer Research, 0(0).
PMID: 36102736 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayLV Lopez et al. (2022), MicroRNA Expression in the Infarcted Heart Following Neonatal Cardiovascular Progenitor Cell Transplantation in a Sheep Model of Stem Cell-Based Repair Cell Transplantation, 31(0):9636897221136.
PMID: 36564913 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureZ Zhang et al. (2021), Regulation of ABCG2 expression by Wnt5a through FZD7 in human pancreatic cancer cells Mol Med Rep, 23(1).
PMID: 33200805 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayX Wan et al. (2021), FOSL2 promotes VEGF-independent angiogenesis by transcriptionnally activating Wnt5a in breast cancer-associated fibroblasts Theranostics, 11(10):4975-4991.
PMID: 33754039 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureT Skaria et al. (2021), Transcriptional Regulation of Drug Metabolizing CYP Enzymes by Proinflammatory Wnt5A Signaling in Human Coronary Artery Endothelial Cells Frontiers in Pharmacology, 12(0):619588.
PMID: 34079452 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayE Ramos-Fern et al. (2021), Wnt5a promotes hippocampal postsynaptic development and GluN2B-induced expression via the eIF2&alpha HRI kinase Scientific Reports, 11(1):7395.
PMID: 33795747 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayY Tai et al. (2021), IgD promotes pannus formation by activating Wnt5A-Fzd5-CTHRC1-NF-kappaB signaling pathway in FLS of CIA rats and the regulation of IgD-Fc-Ig fusion protein International immunopharmacology, 101(0):108261.
PMID: 34688134 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayT Radaszkiew et al. (2021), RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy Elife, 10(0).
PMID: 34702444 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayD Feng et al. (2021), Regulation of Wnt/PCP signaling through p97/VCP-KBTBD7-mediated Vangl ubiquitination and endoplasmic reticulum-associated degradation Science Advances, 7(20).
PMID: 33990333 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayM Jurásek et al. (2021), Phosphorylation-induced changes in the PDZ domain of Dishevelled 3 Scientific Reports, 11(1):1484.
PMID: 33452274 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayM Kowalski-J et al. (2021), Frizzled BRET sensors based on bioorthogonal labeling of unnatural amino acids reveal WNT-induced dynamics of the cysteine-rich domain Science Advances, 7(46):eabj7917.
PMID: 34757789 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJ Neuhaus et al. (2021), Immunocytochemical Analysis of Endogenous Frizzled-(Co-)Receptor Interactions and Rapid Wnt Pathway Activation in Mammalian Cells International Journal of Molecular Sciences, 22(21).
PMID: 34769487 -
Species: Transgenic Mouse
Sample Types: Whole Tissue
Applications: BioassayA Böttcher et al. (2021), Non-canonical Wnt/PCP signalling regulates intestinal stem cell lineage priming towards enteroendocrine and Paneth cell fates Nature Cell Biology, 23(1):23-31.
PMID: 33398177 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayNC DeVito et al. (2021), Pharmacological Wnt ligand inhibition overcomes key tumor-mediated resistance pathways to anti-PD-1 immunotherapy Cell Reports, 35(5):109071.
PMID: 33951424 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureP Kozielewic et al. (2020), Structural insight into small molecule action on Frizzleds Nat Commun, 11(1):414.
PMID: 31964872 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayC Luo et al. (2020), H3K27me3-mediated PGC1&alpha gene silencing promotes melanoma invasion through WNT5A and YAP J. Clin. Invest., 130(2):853-862.
PMID: 31929186 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayE Flores-Her et al. (2020), Canonical and non-canonical Wnt signaling are simultaneously activated by Wnts in colon cancer cells Cell. Signal., 72(0):109636.
PMID: 32283254 -
Species: Mouse
Sample Types: Whole Cells
Applications: Cell CultureSY Jeong et al. (2020), Ryk modulates the niche activity of mesenchymal stromal cells by fine-tuning canonical Wnt signaling Exp. Mol. Med., 0(0).
PMID: 32724069 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureW Kawarazaki et al. (2020), Salt causes aging-associated hypertension via vascular Wnt5a under Klotho deficiency J. Clin. Invest., 0(0).
PMID: 32597829 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayQ Liu et al. (2020), Wnt5a/CaMKII/ERK/CCL2 axis is required for tumor-associated macrophages to promote colorectal cancer progression Int. J. Biol. Sci., 16(6):1023-1034.
PMID: 32140070 -
Species: Rat
Applications: Cell CultureM Mecha et al. (2020), Involvement of Wnt7a in the role of M2c microglia in neural stem cell oligodendrogenesis J Neuroinflammation, 17(1):88.
PMID: 32192522 -
Species: Bovine
Sample Types: Whole Cells
Applications: BioassayM Díaz-Corán et al. (2020), Norrin restores blood-retinal barrier properties after vascular endothelial growth factor-induced permeability J. Biol. Chem., 0(0).
PMID: 32086377 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayB Theivanthi et al. (2020), A tumor-intrinsic PD-L1-NLRP3 inflammasome signaling pathway drives resistance to anti-PD-1 immunotherapy J. Clin. Invest., 0(0).
PMID: 32017708 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureX Qiao et al. (2020), Wnt5a regulates Ameloblastoma Cell Migration by modulating Mitochondrial and Cytoskeletal Dynamics J Cancer, 11(18):5490-5502.
PMID: 32742496 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayH Karvonen et al. (2020), Glucocorticoids induce differentiation and chemoresistance in ovarian cancer by promoting ROR1-mediated stemness Cell Death Dis, 11(9):790.
PMID: 32989221 -
Species: Human
Sample Types: Whole Cells
Applications: ControlQ Chen et al. (2020), Egr-1 mediates low-dose arecoline induced human oral mucosa fibroblast proliferation via transactivation of Wnt5a expression BMC Mol Cell Biol, 21(1):80.
PMID: 33167868 -
Species: Mouse
Sample Types: Whole Tissue
Applications: Tissue CultureC Morenilla- et al. (2020), A Zic2-regulated switch in a noncanonical Wnt/&betacatenin pathway is essential for the formation of bilateral circuits Sci Adv, 6(46).
PMID: 33188033 -
Species: Mouse
Sample Types: Reference Standard
Applications: ELISA StandardS Ikezu et al. (2020), Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities Mol. Psychiatry, 0(0).
PMID: 32071385 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayA Reggio et al. (2020), Adipogenesis of skeletal muscle fibro/adipogenic progenitors is affected by the WNT5a/GSK3/beta-catenin axis Cell Death Differ., 0(0).
PMID: 32382110 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayC Bose et al. (2020), Rlip Depletion Suppresses Growth of Breast Cancer Cancers (Basel), 12(6).
PMID: 32498332 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayX Qiao et al. (2020), Wnt5a regulates Ameloblastoma Cell Migration by modulating Mitochondrial and Cytoskeletal Dynamics J Cancer, 11(18):5490-5502.
PMID: 32742496 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayK Wei et al. (2020), Notch signalling drives synovial fibroblast identity and arthritis pathology Nature, 582(7811):259-264.
PMID: 32499639 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayS Zhang et al. (2019), Inhibition of chemotherapy resistant breast cancer stem cells by a ROR1 specific antibody Proc. Natl. Acad. Sci. U.S.A., 116(4):1370-1377.
PMID: 30622177 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayG Lutze et al. (2019), Non-canonical WNT-signaling controls differentiation of lymphatics and extension lymphangiogenesis via RAC and JNK signaling Sci Rep, 9(1):4739.
PMID: 30894622 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayH Karvonen et al. (2019), Wnt5a and ROR1 activate non-canonical Wnt signaling via RhoA in TCF3-PBX1 acute lymphoblastic leukemia and highlight new treatment strategies via Bcl-2 co-targeting Oncogene, 0(0).
PMID: 30631148 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayK Kaiser et al. (2019), WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis Nat Commun, 10(1):1498.
PMID: 30940800 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayZ Ji et al. (2019), Systematically understanding the immunity leading to CRPC progression PLoS Comput. Biol., 15(9):e1007344.
PMID: 31504033 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayX Wu et al. (2019), Mesenchymal WNT-5A/5B Signaling Represses Lung Alveolar Epithelial Progenitors Cells, 8(10).
PMID: 31557955 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayG Barbero et al. (2019), An Autocrine Wnt5a Loop Promotes NF-kappaB Pathway Activation and Cytokine/Chemokine Secretion in Melanoma Cells, 8(9).
PMID: 31510045 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayMM de Rezende et al. (2019), Divergent effects of Wnt5b on IL-3- and GM-CSF-induced myeloid differentiation Cell. Signal., 67(0):109507.
PMID: 31857239 -
Species: Rat
Sample Types: Whole Cells
Applications: BioassayF Zhao et al. (2019), Construction of a vascularized bladder with autologous adipose-derived stromal vascular fraction cells combined with bladder acellular matrix via tissue engineering J Tissue Eng, 10(0):2041731419891.
PMID: 31827758 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayBK Tusi et al. (2018), Population snapshots predict early haematopoietic and erythroid hierarchies Nature, 0(0).
PMID: 29466336 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayS Kokabu et al. (2018), BMP3 expression by osteoblast lineage cells is regulated by canonical Wnt signaling FEBS Open Bio, 8(2):168-176.
PMID: 29435407 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayBD Boyan et al. (2018), Role of Wnt11 during Osteogenic Differentiation of Human Mesenchymal Stem Cells on Microstructured Titanium Surfaces Sci Rep, 8(1):8588.
PMID: 29872092 -
P Qian et al. (2018), Retinoid-Sensitive Epigenetic Regulation of the Hoxb Cluster Maintains Normal Hematopoiesis and Inhibits Leukemogenesis Cell Stem Cell, 22(5):740-754.e7.
PMID: 29727682 -
Sample Types: Whole Cells
Applications: BioassayHK Lin et al. (2018), Caveolin-1 down-regulation is required for Wnt5a-Frizzled 2 signalling in Ha-RasV12-induced cell transformation J. Cell. Mol. Med., 0(0).
PMID: 29502342 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayBN Nakamura et al. (2018), A20 regulates canonical wnt-signaling through an interaction with RIPK4 PLoS ONE, 13(5):e0195893.
PMID: 29718933 -
Species: Mouse
Sample Types: Complex Sample Type
Applications: BioassayT Takahashi et al. (2018), The Coordinated Activities of nAChR and Wnt Signaling Regulate Intestinal Stem Cell Function in Mice Int J Mol Sci, 19(3).
PMID: 29510587 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayH Xiong et al. (2018), miR-613 inhibits cell migration and invasion by downregulating Daam1 in triple-negative breast cancer Cell. Signal., 44(0):33-42.
PMID: 29339084 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayJ Xu et al. (2018), Reduced Cdc42 Activity Compromises Hematopoiesis-Supportive Function Of Fanconi Anemia Mesenchymal Stromal Cells Stem Cells, 0(0).
PMID: 29377497 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayYK Bae et al. (2018), Intracellular Calcium Determines the Adipogenic Differentiation Potential of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells via the Wnt5a/?-Catenin Signaling Pathway Stem Cells Int, 2018(0):6545071.
PMID: 30123291 -
Species: Rat
Sample Types: Whole Cells
Applications: BioassaySH Lee et al. (2018), Reciprocal control of excitatory synapse numbers by Wnt and Wnt inhibitor PRR7 secreted on exosomes Nat Commun, 9(1):3434.
PMID: 30143647 -
Species: Mouse
P Andersen et al. (2018), Precardiac organoids form two heart fields via Bmp/Wnt signaling Nat Commun, 9(1):3140.
PMID: 30087351 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayP Periasamy et al. (2018), Identification of genes which regulate stroma-dependent in vitro hematopoiesis PLoS ONE, 13(10):e0205583.
PMID: 30308055 -
J Heliste et al. (2018), Receptor tyrosine kinase profiling of ischemic heart identifies ROR1 as a potential therapeutic target BMC Cardiovasc Disord, 18(1):196.
PMID: 30342492 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayBA Brown et al. (2018), Aging differentially modulates the Wnt pro-survival signalling pathways in vascular smooth muscle cells Aging Cell, 0(0):e12844.
PMID: 30548452 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayA Ogorodniko et al. (2018), Transcriptome 3'end organization by PCF11 links alternative polyadenylation to formation and neuronal differentiation of neuroblastoma Nat Commun, 9(1):5331.
PMID: 30552333 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJ Baio et al. (2018), Spaceflight Activates Protein Kinase C Alpha Signaling and Modifies the Developmental Stage of Human Neonatal Cardiovascular Progenitor Cells Stem Cells Dev., 0(0).
PMID: 29320953 -
Species: Human
Sample Types: Whole Cells
Applications: DifferentiationDE Reichman et al. (2018), Wnt inhibition promotes vascular specification of embryonic cardiac progenitors Development, 145(1).
PMID: 29217753 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayI Ackers et al. (2018), Blocking Wnt5a signaling decreases CD36 expression and foam cell formation in atherosclerosis Cardiovasc. Pathol., 34(0):1-8.
PMID: 29474941 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayT Rosengren et al. (2018), TSC1 and TSC2 regulate cilia length and canonical Hedgehog signaling via different mechanisms Cell. Mol. Life Sci., 0(0).
PMID: 29396625 -
Species: Rat
Sample Types: In Vivo
Applications: In VivoZ Li et al. (2018), Wnt5a suppresses inflammation-driven intervertebral disc degeneration via a TNF-α/NF-κB -Wnt5a negative-feedback loop Osteoarthr. Cartil., 0(0).
PMID: 29656141 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureYK Cho et al. (2018), Effect of SFRP5 (Secreted Frizzled-Related Protein 5) on the WNT5A (Wingless-Type Family Member 5A)-Induced Endothelial Dysfunction and Its Relevance With Arterial Stiffness in Human Subjects Arterioscler. Thromb. Vasc. Biol., 0(0).
PMID: 29674475 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayMK Hasan et al. (2018), Wnt5a induces ROR1 to recruit DOCK2 to activate Rac1/2 in chronic lymphocytic leukemia Blood, 0(0).
PMID: 29678828 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayK Kessenbroc et al. (2017), Diverse regulation of mammary epithelial growth and branching morphogenesis through noncanonical Wnt signaling Proc. Natl. Acad. Sci. U.S.A, 0(0).
PMID: 28270600 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayT Skaria et al. (2017), WIF1 prevents Wnt5A mediated LIMK/CFL phosphorylation and adherens junction disruption in human vascular endothelial cells J Inflamm (Lond), 14(0):10.
PMID: 28529460 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayO Bernatik et al. (2017), A Novel Role for the BMP Antagonist Noggin in Sensitizing Cells to Non-canonical Wnt-5a/Ror2/Disheveled Pathway Activation Front Cell Dev Biol, 5(0):47.
PMID: 28523267 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJ Jang et al. (2017), WNT/?-catenin pathway modulates the TNF-?-induced inflammatory response in bronchial epithelial cells Biochem. Biophys. Res. Commun, 0(0).
PMID: 28137581 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayT Skaria et al. (2017), Wnt5A/Ryk signaling critically affects barrier function in human vascular endothelial cells Cell Adh Migr, 11(1):24-38.
PMID: 27159116 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayMW Susman et al. (2017), Kinesin superfamily protein Kif26b links Wnt5a-Ror signaling to the control of cell and tissue behaviors in vertebrates Elife, 6(0).
PMID: 28885975 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayKB Schou et al. (2017), KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling Nat Commun, 8(0):14177.
PMID: 28134340 -
Species: Human
Sample Types: Whole Cells
P Paclíková et al. (2017), N-terminal part of Dishevelled DEP domain is required for Wnt/?-catenin signaling in mammalian cells Mol. Cell. Biol., 0(0).
PMID: 28674183 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayY Chen et al. (2017), Generation of iPSC-derived limb progenitor-like cells for stimulating phalange regeneration in the adult mouse Cell Discov, 3(0):17046.
PMID: 29263795 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayR Behera et al. (2017), Inhibition of age-related therapy resistance in melanoma by rosiglitazone-mediated induction of Klotho Clin. Cancer Res, 0(0).
PMID: 28232477 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayK Strakova et al. (2017), The tyrosine Y250(2.39) in Frizzled 4 defines a conserved motif important for structural integrity of the receptor and recruitment of Disheveled Cell. Signal., 38(0):85-96.
PMID: 28668722 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayMMF Steinbusch et al. (2017), Expression of RMRP RNA is regulated in chondrocyte hypertrophy and determines chondrogenic differentiation Sci Rep, 7(1):6440.
PMID: 28743979 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayZ Prgomet et al. (2017), Higher expression of WNT5A protein in oral squamous cell carcinoma compared with dysplasia and oral mucosa with a normal appearance Eur. J. Oral Sci., 0(0).
PMID: 28603941 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayI Savvidou et al. (2017), Beta-catenin inhibitor BC2059 is efficacious as monotherapy or in combination with proteasome inhibitor bortezomib in multiple myeloma Mol. Cancer Ther., 0(0).
PMID: 28500235 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayA Ndoye et al. (2017), ATG5 mediates a positive feedback loop between Wnt signaling and autophagy in melanoma Cancer Res., 0(0).
PMID: 28887323 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayY Gao et al. (2017), Ring finger protein 43 associates with gastric cancer progression and attenuates the stemness of gastric cancer stem-like cells via the Wnt-?/catenin signaling pathway Stem Cell Res Ther, 8(1):98.
PMID: 28446252 -
Species: Mouse
Sample Types: Whole Embryo
Applications: BioassayK Minegishi et al. (2017), A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking Dev. Cell, 40(5):439-452.e4.
PMID: 28292423 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayT Poobalasin et al. (2017), Heterozygous Vangl2(Looptail) mice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair Dis Model Mech, 0(0).
PMID: 28237967 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJ Jang et al. (2017), LPS-induced inflammatory response is suppressed by Wnt inhibitors, Dickkopf-1 and LGK974 Sci Rep, 7(0):41612.
PMID: 28128299 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayM Vesel et al. (2017), ABCB1 and ABCG2 drug transporters are differentially expressed in non-small cell lung cancers (NSCLC) and expression is modified by cisplatin treatment via altered Wnt signaling Respir. Res, 18(1):52.
PMID: 28340578 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJ Petersen et al. (2017), Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling Nat Commun, 8(1):226.
PMID: 28790300 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayMK Connacher et al. (2017), Rear-polarized Wnt5a-receptor-actin-myosin-polarity (WRAMP) structures promote the speed and persistence of directional cell migration Mol. Biol. Cell, 0(0).
PMID: 28592632 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayHoeke A Baarsma (2016), Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD J. Exp. Med, 0(0).
PMID: 27979969 -
Species: N/A
Applications: Bioassay(2016), Wnt-5a/Frizzled9 receptor signaling through the G?o/G?? complex regulates dendritic spine formation J Biol Chem, 0(0).
PMID: 27402827 -
Species: Human
Sample Types: Whole Cells
Applications: Bioassay(2016), IL-4 Causes Hyperpermeability of Vascular Endothelial Cells through Wnt5A Signaling PLoS ONE, 11(5):e0156002.
PMID: 27214384 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayRonald A DePinho (2016), Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth Cell, 167(5):1281-1295.e18.
PMID: 27863244 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayO Lyros et al. (2016), Dysregulation of WNT5A/ROR2 Signaling Characterizes the Progression of Barrett's-associated Esophageal Adenocarcinoma Mol Cancer Res, 0(0).
PMID: 27084312 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayTu Z et al. (2016), Uterine RAC1 via Pak1-ERM signaling directs normal luminal epithelial integrity conducive to on-time embryo implantation in mice. Cell Death Differ, 23(1):169-81.
PMID: 26184908 -
Species: Human
Sample Types: Whole Cells
Applications: Bioassay(2016), KLF4 transcriptionally activates non-canonical WNT5A to control epithelial stratification Sci Rep, 6(0):26130.
PMID: 27184424 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayTiwary S et al. (2016), FRIZZLED7 Is Required for Tumor Inititation and Metastatic Growth of Melanoma Cells. PLoS ONE, 11(1):e0147638.
PMID: 26808375 -
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay(2016), Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms Nat. Med, 0(0).
PMID: 27918563 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayHorigane S et al. (2016), Facilitation of axon outgrowth via a Wnt5a-CaMKK-CaMKIalpha pathway during neuronal polarization. Mol Brain, 9(1):8.
PMID: 26772170 -
Species: Human
Sample Types: Whole Cells
Applications: Bioassay(2016), Identification of proliferative and mature ?-cells in the islets of Langerhans Nature, 535(7612):430-4.
PMID: 27398620 -
Species: Human
Sample Types: Whole Cells
Applications: Bioassay(2016), WNT5A signaling impairs breast cancer cell migration and invasion via mechanisms independent of the epithelial-mesenchymal transition J Exp Clin Cancer Res, 35(1):144.
PMID: 27623766 -
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay(2016), Wnt5a induces renal AQP2 expression by activating calcineurin signalling pathway Nat Commun, 7(0):13636.
PMID: 27892464 -
Species: Human
Sample Types: Whole Cells
Applications: Bioassay(2016), Increased Wnt5a in squamous cell lung carcinoma inhibits endothelial cell motility BMC Cancer, 16(1):915.
PMID: 27876017 -
Species: Mouse
Sample Types: In Vivo
Applications: In VivoOmar Farah (2016), Porcupine-dependent Wnt signaling controls stromal proliferation and endometrial gland maintenance through the action of distinct WNTs Dev. Biol, 0(0).
PMID: 27965056 -
Species: Human
Sample Types: Whole Cells
Applications: Bioassay(2016), Regeneration of Articular Cartilage by Human ESC-Derived Mesenchymal Progenitors Treated Sequentially With BMP-2 and Wnt5a Stem Cells Transl Med, 0(0).
PMID: 27496569 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayOuji Y et al. (2015), Partial maintenance and long-term expansion of murine skin epithelial stem cells by Wnt-3a in vitro. J Invest Dermatol, 135(6):1598-608.
PMID: 25437427 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassaySuryawanshi A et al. (2015), Canonical wnt signaling in dendritic cells regulates Th1/Th17 responses and suppresses autoimmune neuroinflammation. J Immunol, 194(7):3295-304.
PMID: 25710911 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayZhao D et al. (2015), WNT5A transforms intestinal CD8alphaalpha(+) IELs into an unconventional phenotype with pro-inflammatory features. BMC Gastroenterol, 15(0):173.
PMID: 26652024 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayHandorf A et al. (2015), Endogenously produced Indian Hedgehog regulates TGFbeta-driven chondrogenesis of human bone marrow stromal/stem cells. Stem Cells Dev, 24(8):995-1007.
PMID: 25519748 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayLee J et al. (2014), Interleukin-1beta-induced Wnt5a enhances human corneal endothelial cell migration through regulation of Cdc42 and RhoA. Mol Cell Biol, 34(18):3535-45.
PMID: 25022753 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayTsai H et al. (2014), Wnts enhance neurotrophin-induced neuronal differentiation in adult bone-marrow-derived mesenchymal stem cells via canonical and noncanonical signaling pathways. PLoS ONE, 9(8):e104937.
PMID: 25170755 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayLiu et al. (2014), Wnt5a through noncanonical Wnt/JNK or Wnt/PKC signaling contributes to the differentiation of mesenchymal stem cells into type II alveolar epithelial cells in vitro. PLoS ONE, 9(3):e90229.
PMID: 24658098 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayYu C et al. (2014), Recombinant Wnt3a and Wnt5a elicit macrophage cytokine production and tolerization to microbial stimulation via Toll-like receptor 4. Eur J Immunol, 44(5):1480-90.
PMID: 24643512 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayEkstrom E et al. (2014), WNT5A induces release of exosomes containing pro-angiogenic and immunosuppressive factors from malignant melanoma cells. Mol Cancer, 13(0):88.
PMID: 24766647 -
Species: Rat
Sample Types: Tissue Homogenates
Applications: BioassayDawes L et al. (2014), Interactions between lens epithelial and fiber cells reveal an intrinsic self-assembly mechanism. Dev Biol, 385(2):291-303.
PMID: 24211762 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayZhang A et al. (2014), Wnt5a promotes migration of human osteosarcoma cells by triggering a phosphatidylinositol-3 kinase/Akt signals. Cancer Cell Int, 14(1):15.
PMID: 24524196 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayPovinelli B et al. (2014), Wnt5a regulates hematopoietic stem cell proliferation and repopulation through the Ryk receptor. Stem Cells, 32(1):105-15.
PMID: 23939973 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayMany A et al. (2014), Both canonical and non-canonical Wnt signaling independently promote stem cell growth in mammospheres. PLoS ONE, 9(7):e101800.
PMID: 25019931 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayKilander M et al. (2014), Assessment of Frizzled 6 membrane mobility by FRAP supports G protein coupling and reveals WNT-Frizzled selectivity. Cell Signal, 26(9):1943-9.
PMID: 24873871 -
Species: Rat
Sample Types: Whole Cells
Applications: BioassayGodoy J et al. (2014), Wnt-5a ligand modulates mitochondrial fission-fusion in rat hippocampal neurons. J Biol Chem, 289(52):36179-93.
PMID: 25336659 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayBainbridge T et al. (2014), Evolutionary divergence in the catalytic activity of the CAM-1, ROR1 and ROR2 kinase domains. PLoS ONE, 9(7):e102695.
PMID: 25029443 -
Species: Rat
Sample Types: Whole Cells
Applications: BioassaySmith A et al. (2014), Isolation and characterization of resident endogenous c-Kit+ cardiac stem cells from the adult mouse and rat heart. Nat Protoc, 9(7):1662-81.
PMID: 24945383 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayKeats E et al. (2014), Switch from canonical to noncanonical Wnt signaling mediates high glucose-induced adipogenesis. Stem Cells, 32(6):1649-60.
PMID: 24496952 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayZhao C et al. (2014), GEC-derived SFRP5 inhibits Wnt5a-induced macrophage chemotaxis and activation. PLoS ONE, 9(1):e85058.
PMID: 24416340 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayOkamoto M et al. (2014), Noncanonical Wnt5a enhances Wnt/beta-catenin signaling during osteoblastogenesis. Sci Rep, 4(0):4493.
PMID: 24670389 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayZhao Y et al. (2014), Wnt5a promotes inflammatory responses via nuclear factor kappaB (NF-kappaB) and mitogen-activated protein kinase (MAPK) pathways in human dental pulp cells. J Biol Chem, 289(30):21028-39.
PMID: 24891513 -
Species: N/A
Sample Types: N/A
Applications: Western BlotIshizuya-Oka et al. (2014), Thyroid hormone-regulated Wnt5a/Ror2 signaling is essential for dedifferentiation of larval epithelial cells into adult stem cells in the Xenopus laevis intestine. PLoS ONE, 9(9):e107611.
PMID: 25211363 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayLinnskog R et al. (2014), Interleukin-6 drives melanoma cell motility through p38alpha-MAPK-dependent up-regulation of WNT5A expression. Mol Oncol, 8(8):1365-78.
PMID: 24954857 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayBentzinger C et al. (2014), Wnt7a stimulates myogenic stem cell motility and engraftment resulting in improved muscle strength. J Cell Biol, 205(1):97-111.
PMID: 24711502 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayLee G et al. (2014), Prostate cancer bone metastases acquire resistance to androgen deprivation via WNT5A-mediated BMP-6 induction. Br J Cancer, 110(6):1634-44.
PMID: 24518599 -
Li S et al. (2014), IL-1beta mediates MCP-1 induction by Wnt5a in gastric cancer cells. BMC Cancer, 14(0):480.
PMID: 24993819 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayCajanek L et al. (2013), Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons. Mol Cell Biol, 33(1):59-70.
PMID: 23109420 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayThrasivoulou C et al. (2013), Activation of intracellular calcium by multiple Wnt ligands and translocation of beta-catenin into the nucleus: a convergent model of Wnt/Ca2+ and Wnt/beta-catenin pathways. J Biol Chem, 288(50):35651-9.
PMID: 24158438 -
Species: Mouse
Sample Types: In Vivo
Applications: In VivoLi B et al. (2013), Wingless-type mammary tumor virus integration site family, member 5A (Wnt5a) regulates human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein 120 (gp120)-induced expression of pro-inflammatory cytokines via the Ca2+/calmodulin-dependent protein kinase II (CaMKII) and c-Jun N-terminal kinase (JNK) signaling pathways. J Biol Chem, 288(19):13610-9.
PMID: 23539626 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayFlorian M et al. (2013), A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing. Nature, 503(7476):392-6.
PMID: 24141946 -
Ye Z et al. (2013), Wnt5a uses CD146 as a receptor to regulate cell motility and convergent extension. Nat Commun, 4(0):2803.
PMID: 24335906 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayGoel S et al. (2012), Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts. J. Biol. Chem., 287(20):16454-66.
PMID: 22433869 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayTran H et al. (2012), Reversible modification of adenomatous polyposis coli (APC) with K63-linked polyubiquitin regulates the assembly and activity of the beta-catenin destruction complex. J Biol Chem, 287(34):28552-63.
PMID: 22761442 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayWilson TR et al. (2012), Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 487(7408):505-9.
PMID: 22763448 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayCohen E et al. (2012), Wnt5a and Wnt11 are essential for second heart field progenitor development. Development, 139(11):1931-40.
PMID: 22569553 -
Species: Rat
Sample Types: Whole Cells
Applications: BioassayBlakely BD et al. (2011), Wnt5a regulates midbrain dopaminergic axon growth and guidance. PLoS ONE, 6(3):e18373.
PMID: 21483795 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayScheel C et al. (2011), Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast. Cell, 145(6):926-40.
PMID: 21663795 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayKilander MB et al. (2011), WNT-5A stimulates the GDP/GTP exchange at pertussis toxin-sensitive heterotrimeric G proteins. Cell. Signal., 23(3):550-4.
PMID: 21070854 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayLi B et al. (2011), WNT5A Signaling Contributes to Abeta-Induced Neuroinflammation and Neurotoxicity. PLoS ONE, 6(8):e22920.
PMID: 21857966 -
Species: Human
Sample Types: Recombinant Protein
Applications: Binding AssayBourhis E et al. (2010), Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6. J. Biol. Chem., 285(12):9172-9.
PMID: 20093360 -
Species: Human
Sample Types: Whole Cells
Gudjonsson JE et al. (2010), Evidence for altered Wnt signaling in psoriatic skin. J. Invest. Dermatol., 130(7):1849-59.
PMID: 20376066 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayO'Connell MP et al. (2010), The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma. Oncogene, 29(1):34-44.
PMID: 19802008 -
Species: Zebrafish
Sample Types: Whole Cells
Applications: BioassayMa LH et al. (2009), Establishment of a transitory dorsal-biased window of localized Ca2+ signaling in the superficial epithelium following the mid-blastula transition in zebrafish embryos. Dev. Biol., 327(1):143-57.
PMID: 19133253 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayVerkaar F et al. (2009), Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2+-mobilization in Human Embryonic Kidney 293 cells. Cell. Signal., 21(1):22-33.
PMID: 18929644 -
Species: Human
Sample Types: Whole Cells
Applications: BioassaySteele BM et al. (2009), Canonical Wnt signaling negatively regulates platelet function. Proc. Natl. Acad. Sci. U.S.A., 106(47):19836-41.
PMID: 19901330 -
Species: Mouse
Sample Types: In Vivo
Applications: In VivoGogolla N et al. (2009), Wnt signaling mediates experience-related regulation of synapse numbers and mossy fiber connectivities in the adult hippocampus. Neuron, 62(4):510-25.
PMID: 19477153 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayO'Connell MP et al. (2009), Wnt5A activates the calpain-mediated cleavage of filamin A. J. Invest. Dermatol., 129(7):1782-9.
PMID: 19177143 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayEndo Y et al. (2008), Wnt-3a and Dickkopf-1 stimulate neurite outgrowth in Ewing tumor cells via a Frizzled3- and c-Jun N-terminal kinase-dependent mechanism. Mol. Cell. Biol., 28(7):2368-79.
PMID: 18212053 -
Species: Human
Sample Types: Whole Cells
Applications: BioassaySafholm A et al. (2008), The Wnt-5a-derived hexapeptide Foxy-5 inhibits breast cancer metastasis in vivo by targeting cell motility. Clin. Cancer Res., 14(20):6556-63.
PMID: 18927296 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayMatushansky I et al. (2007), Derivation of sarcomas from mesenchymal stem cells via inactivation of the Wnt pathway. J. Clin. Invest., 117(11):3248-57.
PMID: 17948129 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayMasckauchan TN et al. (2006), Wnt5a signaling induces proliferation and survival of endothelial cells in vitro and expression of MMP-1 and Tie-2. Mol. Biol. Cell, 17(12):5163-72.
PMID: 17035633 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayHenry C et al. (0), Targeting the ROR1 and ROR2 receptors in epithelial ovarian cancer inhibits cell migration and invasion. Oncotarge6(37):40310-26.
PMID: 26515598 -
Species: Human
Sample Types: Organoid
Applications: BioassayIdeno H et al. (0), Human PSCs determine the competency of cerebral organoid differentiation via FGF signaling and epigenetic mechanisms. iScienc25(10):105140.
PMID: 36185382
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Customer Reviews for Recombinant Human/Mouse Wnt-5a Protein (8)
Customer Images
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Application: CellProlifReason for Rating: wnt5a was used to test if it an promote stem cell proliferation.Verified Customer | Posted 06/18/2022put it in -80 freezer
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Application: In vitro bioactivity in cell cultureVerified Customer | Posted 03/01/2022Kept in -80 freezer
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Application: Enzymatic activity in vitroVerified Customer | Posted 11/29/2021avoid freezing and refreezing, and kept in -80
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Application: Luciferase activity.Reason for Rating: very good productVerified Customer | Posted 08/06/2021Try to avoid thaw and freeze many times.
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Application: Enzymatic activity in vitroReason for Rating: it worked very good.Verified Customer | Posted 08/06/2021preserve it under -20 after reconstitution
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Application: Binding assay/Protein-protein interactionVerified Customer | Posted 02/19/2021
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Application: Binding assay/Protein-protein interactionVerified Customer | Posted 10/07/2020
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Application: In vitro bioactivity in cell cultureReason for Rating: Works great with invitro studiesVerified Customer | Posted 03/22/2018
There are no reviews that match your criteria.