What is the difference between the two Recombinant Human/Mouse/Rat BMP-2 Proteins (Catalog # 355-BM and 355-BEC)?

Catalog # 355-BM is produced in a mammalian system using CHO cells and exhibits better activity in our routine QC bioassay, while Catalog # 355-BEC is produced in an E. coli expression system and is less expensive. Bioactivity of both Human/Mouse/Rat BMP-2 Proteins is measured in an alkaline phosphatase assay using by ATDC5 mouse chondrogenic cells. For 355-BM, the ED50 for this effect is 40-200 ng/mL, while for 355-BEC, the ED50 range is 80-480 ng/mL. We recommend reviewing our list of publications under the Citations tab for both 355-BM and 355-BEC to determine which of the two proteins is most suitable for your experiment.

Does Recombinant Human/Mouse/Rat BMP-2 Protein (Catalog # 355-BM) have a histidine tag?

Recombinant Human/Mouse/Rat BMP-2 Protein (Catalog # 355-BM) does not contain a histidine tag. The sequence of this protein contains Gln283-Arg396 aa based on Accession # P12643.

Recombinant Human/Mouse/Rat BMP-2 Protein

Name: Recombinant Human/Mouse/Rat BMP-2 Protein
Brand: R&D Systems
SKU: 355-BM
Rating: 5 (11 reviews)

Catalog # 355-BM | R&D Systems, Inc. a Bio-Techne Brand

(11)

Citations (185)

Product Datasheet / COA / SDS

Catalog #

Availability

Size / Price

Qty

Setting the standard in quality research reagents

Key Product Details

Source:	CHO
Accession #:	P12643
Structure / Form:	Disulfide-linked homodimer
Applications:	Bioactivity

View Full Technical Details for Recombinant Human/Mouse/Rat BMP-2 Protein

Technical Data
Citations (185) / Reviews (11) / FAQs

Product Specifications for Recombinant Human/Mouse/Rat BMP-2 Protein

Source	Chinese Hamster Ovary cell line, CHO-derived BMP-2 protein Gln283-Arg396
Purity	>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin level	<0.10 EU per 1 μg of the protein by the LAL method.
Predicted Molecular Mass	13 kDa (monomer)
SDS-PAGE	13 kDa (monomer)
Activity	Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. Binnerts, M.E. et al. (2004) Biochem. Biophys. Res. Commun. 315(2):272. The ED₅₀ for this effect is 40-200 ng/mL.

Scientific Data Examples for Recombinant Human/Mouse/Rat BMP-2 Protein

	Bioactivity of Human/Mouse/Rat BMP-2 Protein Recombinant human/mouse/rat BMP-2 (355-BM) induces alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line. The ED₅₀ for this effect is 40-200 ng/mL.

Formulation, Preparation and Storage

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

355-BM

Carrier

Formulation	Lyophilized from a 0.2 μm filtered solution in Glycine, Sucrose, Tween® 80 and Glutamic Acid with BSA as a carrier protein.
Reconstitution	Reconstitute at 100-200 μg/mL in sterile 4 mM HCl containing at least 0.1% human or bovine serum albumin.
Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

355-BM/CF

Carrier Free

Formulation	Lyophilized from a 0.2 μm filtered solution in Glycine, Sucrose, Tween® 80 and Glutamic Acid.
Reconstitution	Reconstitute at 100-200 μg/mL in sterile 4 mM HCI.
Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Background: BMP-2

Bone morphogenetic protein 2 (BMP-2) is a member of the BMP subgroup of the TGF-beta superfamily. It plays a dominant role in embryonic dorsal-ventral patterning, organogenesis, limb bud formation, and bone formation and regeneration (1, 2). Human BMP‑2 is synthesized as a 396 amino acid (aa) preproprotein that contains a 23 aa signal sequence, a 259 aa prosegment, and a 114 aa mature region (3). Proteolytic removal of the propeptide enables mature BMP-2 to form active disulfide linked homodimers and heterodimers with BMP-7 (2). Mature monomeric BMP-2 is an 18 kDa glycosylated peptide with seven conserved cysteines that form a cystine knot structure (4). Mature human BMP-2 shares 100% aa sequence identity with mouse and rat BMP-2. It shares 85% aa sequence identity with human BMP-4 and less than 51% with other BMPs. BMP-2 signals through heterodimeric complexes composed of a type I receptor (Activin RI, BMPR‑IA, or BMPR‑IB) and a type II receptor (BMP RII or Activin RIIB) (2, 5). BMP-2 induces chondrocyte proliferation, endochondral bone formation, longitudinal bone growth, and bone and cartilage repair (6, 7). It induces ectopic bone formation or calcification by promoting osteogenic and chondrogenic differentiation in mesenchymal cells, stem cells, and vascular smooth muscle cells (2, 8‑10). BMP-2/BMP-7 heterodimers are significantly more potent than BMP-2 homodimers at inducing bone formation in vivo (11). BMP-2 also promotes the maintenance and repair of colonic epithelium, suppresses neuronal dopamine synthesis and release, induces apoptosis in medulloblastoma cells, and is required for cardiac contractility (12‑15).

Item	Value
References	Kishigami, S. and Y. Mishina (2005) Cytokine Growth Factor Rev. 16:265. Chen, D. et al. (2004) Growth Factors 22:233. Wozney, J. et al. (1988) Science 242:1528. Sun, P.D. and D.R. Davies (1995) Annu. Rev. Biophys. Biomol. Struct. 24:269. Sebald, W. et al. (2004) Biol. Chem. 385:697. De Luca, F. et al. (2001) Endocrinology 142:430. Davidson, E.N.B., et al. (2007) Arthritis Res. Ther. 9:R102. Ryoo, H.-M. et al. (2006) Gene 366:51. Kramer, J. et al. (2000) Mech. Dev. 92:193. Li, X. et al. (2008) Atherosclerosis January 5 epub. Zhu, W. et al. (2004) J. Bone Miner. Res. 19:2021. Peiris, D. et al. (2007) Am. J. Physiol. Gastrointest. Liver Physiol. 292:G753. Kano, Y. et al. (2005) Endocrinology 146:5332. Hallahan, A.R. et al. (2003) Nat. Med. 9:1033. Wang, Y.-X. et al. (2007) Cardiovasc. Res. 74:290.
Long Name	Bone Morphogenetic Protein 2
Entrez Gene IDs	650 (Human); 12156 (Mouse); 29373 (Rat)
Alternate Names	BDA2, BMP-2, BMP-2A, BMP2, BMP2ABone morphogenetic protein 2A, SSFSC, bone morphogenetic protein 2

Citations for Recombinant Human/Mouse/Rat BMP-2 Protein (185)

Showing 1 - 10 of 185 citations Showing All

Filter By:

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for Recombinant Human/Mouse/Rat BMP-2 Protein include:

Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Erdem et al. (2023-07-06), MOBILE pipeline enables identification of context-specific networks and regulatory mechanisms Nature communications
PMID: 37414767
Species: Mouse
Sample Types: Whole Cells
Applications: Differentiation, Differentiation

Nagasaki et al. (2023-05-25), Kielin/chordin-like protein enhances induction of osteoblast differentiation by Bone Morphogenetic Protein-2 FEBS open bio
PMID: 37226930
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

S Das et al. (2023-02-16), ER stress induces upregulation of transcription factor Tbx20 and downstream Bmp2 signaling to promote cardiomyocyte survival The Journal of Biological Chemistry, 2023-00(0):103031.
PMID: 36805334
Species: Rat
Sample Types: Whole Tissue
Applications: In Vivo

Y Hachinohe et al. (2023-01-06), Self-Prepared Hyaluronic Acid/Alkaline Gelatin Composite with Nano-Hydroxyapatite and Bone Morphogenetic Protein for Cranial Bone Formation International Journal of Molecular Sciences, 2023-024(2).
PMID: 36674618
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Y Hachinohe et al. (2022-12-08), Bone Formation on Murine Cranial Bone by Injectable Cross-Linked Hyaluronic Acid Containing Nano-Hydroxyapatite and Bone Morphogenetic Protein Polymers, 2022-114(24).
PMID: 36559734
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Z Shonibare et al. (2022-07-26), Reciprocal SOX2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer Oncogene, 2022-040(4):111066.
PMID: 35905726
Species: Phallusia mammillata
Sample Types: Embryos
Applications: Bioassay

R Chowdhury et al. (2022-06-27), Highly distinct genetic programs for peripheral nervous system formation in chordates Bmc Biology, 2022-020(1):152.
PMID: 35761237
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

M Vora et al. (2022-05-31), Bone morphogenetic protein signaling regulation of AMPK and PI3K in lung cancer cells and C. elegans Cell bioscience, 2022-05-31;12(1):76.
PMID: 35641992
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

AP Leinroth et al. (2022-05-10), Identification of distinct non-myogenic skeletal-muscle-resident mesenchymal cell populations Cell Reports, 2022-039(6):110785.
PMID: 35545045
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

F Kawecki et al. (2022-03-18), Preclinical Evaluation of BMP-9-Treated Human Bone-like Substitutes for Alveolar Ridge Preservation following Tooth Extraction International Journal of Molecular Sciences, 2022-023(6).
PMID: 35328724
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

S Nagel et al. (2022-03-16), The Hematopoietic TALE-Code Shows Normal Activity of IRX1 in Myeloid Progenitors and Reveals Ectopic Expression of IRX3 and IRX5 in Acute Myeloid Leukemia International Journal of Molecular Sciences, 2022-023(6).
PMID: 35328612
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

I López-Anto et al. (2022-03-09), Dynamic regulation of myofibroblast phenotype in cellular senescence Aging Cell, 2022-00(0):e13580.
PMID: 35266275
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

PR Gajjala et al. (2021-10-22), Dysregulated overexpression of Sox9 induces fibroblast activation in pulmonary fibrosis JCI Insight, 2021-10(0).
PMID: 34520400
Species: Rats
Sample Types: In Vivo
Applications: In Vivo

M Moncayo-Do et al. (2021-09-20), The Effect of Pore Directionality of Collagen Scaffolds on Cell Differentiation and In Vivo Osteogenesis Polymers, 2021-013(18).
PMID: 34578088
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

M Zheng et al. (2021-09-11), Bmp Signaling Regulates Hand1 in a Dose-Dependent Manner during Heart Development International Journal of Molecular Sciences, 2021-022(18).
PMID: 34576009
Species: Human
Sample Types: Recombinant Protein
Applications: ELISA Capture

PS Briquez et al. (2021-06-11), Engineered bridge protein with dual affinity for bone morphogenetic protein-2 and collagen enhances bone regeneration for spinal fusion Science Advances, 2021-07(24).
PMID: 34117071
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

VC Cheung et al. (2021-05-18), Pluripotent stem cell-derived endometrial stromal fibroblasts in a cyclic, hormone-responsive, coculture model of human decidua Cell Reports, 2021-035(7):109138.
PMID: 34010658
Species: Human, Mouse
Sample Types: Whole Cells, Whole Tissue
Applications: Bioassay

C Zhou et al. (2021-02-13), FGF8 and BMP2 mediated dynamic regulation of dental mesenchyme proliferation and differentiation via Lhx8/Suv39h1 complex Journal of Cellular and Molecular Medicine, 2021-00(0).
PMID: 33580754
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

K Hiraoka et al. (2020-11-01), Bone Morphogenetic Proteins Inhibit Ciliogenesis of Ependymal Cells in Vitro Tohoku J Exp Med, 2020-1252(3):199-208.
PMID: 33087680
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

BE Schwartz et al. (2020-10-07), Discovery and Targeting of the Signaling Controls of PNPLA3 to Effectively Reduce Transcription, Expression, and Function in Pre-Clinical NAFLD/NASH Settings Cells, 2020-19(10).
PMID: 33036387
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

L Leiendecke et al. (2020-10-07), LSD1 inhibition induces differentiation and cell death in Merkel cell carcinoma EMBO Mol Med, 2020-10(0):e12525.
PMID: 33026191
Species: Human
Sample Types: Cell Culture Supernates, Recombinant Protein
Applications: Surface Plasmon Resonance

T Mang et al. (2020-08-21), BMPR1A is necessary for chondrogenesis and osteogenesis while BMPR1B prevents hypertrophic differentiation J. Cell. Sci., 2020-00(0).
PMID: 32764110
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay

SK Meurer et al. (2020-08-03), Differential regulation of Lipocalin 2 (LCN2) in doxorubicin-resistant 4T1 triple negative breast cancer cells Cell. Signal., 2020-074(0):109731.
PMID: 32758668
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

L Meng et al. (2020-07-31), Vital Roles of Gremlin-1 in Pulmonary Arterial Hypertension Induced by Systemic-to-Pulmonary Shunts J Am Heart Assoc, 2020-09(15):e016586.
PMID: 32750294
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

AS Ibrahim et al. (2020-07-19), Bone Morphogenetic Protein (BMP)4 But Not BMP2 Disrupts the Barrier Integrity of Retinal Pigment Epithelia and Induces Their Migration: A Potential Role in Neovascular Age-Related Macular Degeneration J Clin Med, 2020-09(7).
PMID: 32707711
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A VanCleave et al. (2020-07-07), Development and characterization of the novel human osteosarcoma cell line COS-33 with sustained activation of the mTOR pathway Oncotarget, 2020-011(27):2597-2610.
PMID: 32676162
Species: Mouse
Sample Types: Whole Cell
Applications: Bioassay

A Dudakovic et al. (2020-04-24), Inhibition of the epigenetic suppressor EZH2 primes osteogenic differentiation mediated by BMP2 J. Biol. Chem., 2020-00(0).
PMID: 32332097
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay

A Krouwels et al. (2020-04-14), Bone Morphogenetic Proteins for Nucleus Pulposus Regeneration Int J Mol Sci, 2020-021(8).
PMID: 32295299
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

DA Mázala et al. (2020-03-26), TGF-&beta-driven muscle degeneration and failed regeneration underlie disease onset in a DMD mouse model JCI Insight, 2020-05(6).
PMID: 32213706
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Stich et al. (2020-03-21), Degeneration of Lumbar Intervertebral Discs: Characterization of Anulus Fibrosus Tissue and Cells of Different Degeneration Grades Int J Mol Sci, 2020-021(6).
PMID: 32245213
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

R Castro-Viñ et al. (2020-03-06), Generation and characterization of human induced pluripotent stem cells (iPSCs) from hand osteoarthritis patient-derived fibroblasts Sci Rep, 2020-010(1):4272.
PMID: 32144293
Species: N/A
Sample Types: Protein
Applications: Surface Plasmon Resonance

TJ Broekelman et al. (2020-01-27), Identification of the growth factor binding sequence in the extracellular matrix protein MAGP-1 J. Biol. Chem., 2020-00(0).
PMID: 31988245
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

HJ Zhao et al. (2019-11-28), Bone morphogenetic protein 2 induces the activation of WNT/beta-catenin signaling and human trophoblast invasion through up-regulating BAMBI Cell. Signal., 2019-10(0):109489.
PMID: 31786181
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

D Seo et al. (2019-11-01), The deubiquitinating enzyme PSMD14 facilitates tumor growth and chemoresistance through stabilizing the ALK2 receptor in the initiation of BMP6 signaling pathway EBioMedicine, 2019-149(0):55-71.
PMID: 31685442
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

S Qin et al. (2019-11-01), Fibrochondrogenic differentiation potential of tendon-derived stem/progenitor cells from human patellar tendon J Orthop Translat, 2019-122(0):101-108.
PMID: 32440505
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

M Omi et al. (2019-10-16), Activin A receptor type 1-mediated BMP signaling regulates RANKL-induced osteoclastogenesis via canonical SMAD signaling pathway J. Biol. Chem., 2019-10(0).
PMID: 31619522
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

LR Dutton et al. (2019-10-11), No evidence of Gremlin1-mediated activation of VEGFR2 signalling in endothelial cells J. Biol. Chem., 2019-10(0).
PMID: 31604823
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

J Ren et al. (2019-09-18), Cancer-associated fibroblast-derived Gremlin 1 promotes breast cancer progression Breast Cancer Res., 2019-021(1):109.
PMID: 31533776
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

K Krüger et al. (2019-09-01), Trefoil Factor 3 (TFF3) Is Involved in Cell Migration for Skeletal Repair Int J Mol Sci, 2019-020(17).
PMID: 31480518
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

S Moghadasi et al. (2019-07-05), Neural crest stem cells from human epidermis of aged donors maintain their multipotency in vitro and in vivo Sci Rep, 2019-09(1):9750.
PMID: 31278326
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Li et al. (2019-07-05), Muscle injury promotes heterotopic ossification by stimulating local bone morphogenetic protein-7 production J Orthop Translat, 2019-018(0):142-153.
PMID: 31508317
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

J Li et al. (2019-06-26), TGFbeta-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis Nat Commun, 2019-010(1):2795.
PMID: 31243287
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

WN Addison et al. (2019-04-02), Zfp423 Regulates Skeletal Muscle Regeneration and Proliferation Mol. Cell. Biol., 2019-00(0).
PMID: 30692273
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

M Rosina et al. (2019-04-01), Osteogenic differentiation of skeletal muscle progenitor cells is activated by the DNA damage response Sci Rep, 2019-09(1):5447.
PMID: 30931986
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

HJ Kim et al. (2019-03-22), Zoledronate Enhances Osteocyte-Mediated Osteoclast Differentiation by IL-6/RANKL Axis Int J Mol Sci, 2019-020(6).
PMID: 30909508
Species: Human
Sample Types: Bone Substitute
Applications: Bioassay

X Zhang et al. (2019-03-12), Osteogenic Enhancement Between Icariin and Bone Morphogenetic Protein 2: A Potential Osteogenic Compound for Bone Tissue Engineering Front Pharmacol, 2019-010(0):201.
PMID: 30914948
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

S Supakul et al. (2019-03-02), Pericytes as a Source of Osteogenic Cells in Bone Fracture Healing Int J Mol Sci, 2019-020(5).
PMID: 30832329
Species: Chicken
Sample Types: Tissue Explants
Applications: Bioassay

WKW Ho et al. (2019-02-21), Feather arrays are patterned by interacting signalling and cell density waves PLoS Biol., 2019-017(2):e3000132.
PMID: 30789897
Species: Mouse
Sample Types: Beads
Applications: In Vivo

L Yu et al. (2019-02-05), BMP9 stimulates joint regeneration at digit amputation wounds in mice Nat Commun, 2019-010(1):424.
PMID: 30723209
Species: Porcine
Sample Types: Whole Cells
Applications: Bioassay

T Karakida et al. (2019-02-04), Potential for Drug Repositioning of Midazolam for Dentin Regeneration Int J Mol Sci, 2019-020(3).
PMID: 30720745
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

S Hendrikx et al. (2019-01-29), Endothelial Calcineurin Signaling Restrains Metastatic Outgrowth by Regulating Bmp2 Cell Rep, 2019-026(5):1227-1241.e6.
PMID: 30699351
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

M Subileau et al. (2018-12-27), Bone Morphogenetic Protein 9 Regulates Early Lymphatic-Specified Endothelial Cell Expansion during Mouse Embryonic Stem Cell Differentiation Stem Cell Reports, 2018-10(0).
PMID: 30595547
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

K Oudina et al. (2018-11-20), The paracrine effects of human induced pluripotent stem cells promote bone-like structures via the upregulation of BMP expression in a mouse ectopic model Sci Rep, 2018-18(1):17106.
PMID: 30459360
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

SY Lee et al. (2018-11-16), Glucose metabolism induced by Bmp signaling is essential for murine skeletal development Nat Commun, 2018-19(1):4831.
PMID: 30446646
Species: Human
Sample Types: Nanoparticles
Applications: Bioassay

B Wang et al. (2018-11-12), Nanoparticle-modified chitosan-agarose-gelatin scaffold for sustained release of SDF-1 and BMP-2 Int J Nanomedicine, 2018-113(0):7395-7408.
PMID: 30519022
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

LS Pane et al. (2018-08-30), Tbx1 represses Mef2c gene expression and is correlated with histone 3 deacetylation of the anterior heart field enhancer Dis Model Mech, 2018-011(9).
PMID: 30166330
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

K Sasa et al. (2018-07-12), Monocarboxylate transporter-1 promotes osteoblast differentiation via suppression of p53, a negative regulator of osteoblast differentiation Sci Rep, 2018-08(1):10579.
PMID: 30002387
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

K Koefoed et al. (2018-06-22), The E3 ubiquitin ligase SMURF1 regulates cell-fate specification and outflow tract septation during mammalian heart development Sci Rep, 2018-08(1):9542.
PMID: 29934521
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

YH Chung et al. (2018-05-22), BMP-2 restoration aids in recovery from liver fibrosis by attenuating TGF-?1 signaling Lab. Invest., 2018-00(0).
PMID: 29789683
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

P Jongwattan et al. (2018-05-04), Identification of the effector domain of biglycan that facilitates BMP-2 osteogenic function Sci Rep, 2018-08(1):7022.
PMID: 29728612
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

H Kang et al. (2018-04-11), Somatic activating mutations in MAP2K1 cause melorheostosis Nat Commun, 2018-09(1):1390.
PMID: 29643386
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

P Bozatzi et al. (2018-03-07), PAWS1 controls Wnt signalling through association with casein kinase 1? EMBO Rep., 2018-00(0).
PMID: 29514862
Species: Porcine
Sample Types: Whole Cells
Applications: Bioassay

DM Burmeister et al. (2018-02-18), Delivery of Allogeneic Adipose Stem Cells in Polyethylene Glycol-Fibrin Hydrogels as an Adjunct to Meshed Autografts After Sharp Debridement of Deep Partial Thickness Burns Stem Cells Transl Med, 2018-00(0).
PMID: 29457376
Species: Equine
Sample Types: Whole Cells
Applications: Bioassay

M Desancé et al. (2018-02-10), Chondrogenic Differentiation of Defined Equine Mesenchymal Stem Cells Derived from Umbilical Cord Blood for Use in Cartilage Repair Therapy Int J Mol Sci, 2018-019(2).
PMID: 29439436
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

JB Lees-Shepa et al. (2018-02-02), Activin-dependent signaling in fibro/adipogenic progenitors causes fibrodysplasia ossificans progressiva Nat Commun, 2018-09(1):471.
PMID: 29396429
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

S Kokabu et al. (2017-12-16), BMP3 expression by osteoblast lineage cells is regulated by canonical Wnt signaling FEBS Open Bio, 2017-18(2):168-176.
PMID: 29435407
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

DW Youngstrom et al. (2017-12-15), Intraoperative delivery of the Notch ligand Jagged-1 regenerates appendicular and craniofacial bone defects NPJ Regen Med, 2017-12(0):32.
PMID: 29302365
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

MG Perino et al. (2017-12-12), Ascorbic acid promotes cardiomyogenesis through SMAD1 signaling in differentiating mouse embryonic stem cells PLoS ONE, 2017-112(12):e0188569.
PMID: 29232368
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

WS Fagg et al. (2017-12-01), Magnetic Targeting of Stem Cell Derivatives Enhances Hepatic Engraftment into Structurally Normal Liver Cell Transplant, 2017-126(12):1868-1877.
PMID: 29390880
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Yu et al. (2017-09-05), Smad7 enables STAT3 activation and promotes pluripotency independent of TGF-? signaling Proc. Natl. Acad. Sci. U.S.A., 2017-00(0).
PMID: 28874583
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

SJ Bae et al. (2017-08-16), Acceleration of osteoblast differentiation by a novel osteogenic compound, DMP-PYT, through activation of both the BMP and Wnt pathways Sci Rep, 2017-07(1):8455.
PMID: 28814721
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

J Fan et al. (2017-08-08), Small molecule-mediated tribbles homolog 3 promotes bone formation induced by bone morphogenetic protein-2 Sci Rep, 2017-07(1):7518.
PMID: 28790361
Species: Human, Mouse
Sample Types: Recombinant Protein, Whole Cells
Applications: Bioassay

C Sallon et al. (2017-07-26), Thrombospondin-1 (TSP-1), a new bone morphogenetic protein-2 and -4 (BMP-2/4) antagonist identified in pituitary cells J. Biol. Chem., 2017-00(0).
PMID: 28747434
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

S François et al. (2017-06-27), Synergistic effect of human Bone Morphogenic Protein-2 and Mesenchymal Stromal Cells on chronic wounds through hypoxia-inducible factor-1 ? induction Sci Rep, 2017-07(1):4272.
PMID: 28655873
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

JO Múnera et al. (2017-06-22), Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling Cell Stem Cell, 2017-00(0).
PMID: 28648364
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

J Feng et al. (2017-06-02), BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells in mice Development, 2017-00(0).
PMID: 28576771
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

L Bai et al. (2017-05-31), SMAD1/5 mediates bone morphogenetic protein 2-induced up-regulation of BAMBI expression in human granulosa-lutein cells Cell. Signal., 2017-037(0):52-61.
PMID: 28578012
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

YM Lin et al. (2017-05-08), Critical attributes of human early mesenchymal stromal cell-laden microcarrier constructs for improved chondrogenic differentiation Stem Cell Res Ther, 2017-08(1):93.
PMID: 28482913
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

SJ Bae et al. (2017-04-15), Potent osteogenic activity of a novel imidazobenzimidazole derivative, IBIP Biochem. Biophys. Res. Commun., 2017-0487(2):409-414.
PMID: 28419840
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay

DW Hammers et al. (2017-04-01), Supraphysiological levels of GDF11 induce striated muscle atrophy EMBO Mol Med, 2017-00(0).
PMID: 28270449
Species: Mouse

K Breitkopf- et al. (2017-03-23), BMP-9 interferes with liver regeneration and promotes liver fibrosis Gut, 2017-00(0).
PMID: 28336518
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Yan-Ting Wu (2017-03-01), Bone morphogenetic protein 2 regulates cell-cell communication by down-regulating connexin43 expression in luteinized human granulosa cells Mol. Hum. Reprod, 2017-00(0).
PMID: 27986931
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

O Veraitch et al. (2017-02-21), Induction of hair follicle dermal papilla cell properties in human induced pluripotent stem cell-derived multipotent LNGFR(+)THY-1(+) mesenchymal cells Sci Rep, 2017-07(0):42777.
PMID: 28220862
Species: Xenopus
Sample Types: Blastocele
Applications: Organoid Culture

ML Stevens et al. (2017-02-20), Genomic integration of Wnt/?-catenin and BMP/Smad1 signaling coordinates foregut and hindgut transcriptional program Development, 2017-00(0).
PMID: 28219948
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Riba et al. (2017-02-15), Explicit Modeling of siRNA-Dependent On- and Off-Target Repression Improves the Interpretation of Screening Results Cell Syst, 2017-04(2):182-193.e4.
PMID: 28215525
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

SV Hegarty et al. (2017-02-08), Endocytosis contributes to BMP2-induced Smad signalling and neuronal growth Neurosci. Lett, 2017-0643(0):32-37.
PMID: 28188849
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

S Sripathy et al. (2017-01-31), Screen for reactivation of MeCP2 on the inactive X chromosome identifies the BMP/TGF-? superfamily as a regulator of XIST expression Proc. Natl. Acad. Sci. U.S.A, 2017-00(0).
PMID: 28143937
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

T Jung et al. (2017-01-19), Effect of BMP-2 Delivery Mode on Osteogenic Differentiation of Stem Cells Stem Cells Int, 2017-02017(0):7859184.
PMID: 28197209
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016-12-15), Tumor-Derived Factors and Reduced p53 Promote Endothelial Cell Centrosome Over-Duplication PLoS ONE, 2016-111(12):e0168334.
PMID: 27977771
Species: Bovine
Sample Types: Whole Cells
Applications: Bioassay

G B de Souza (2016-12-07), Bovine ovarian stem cells differentiate into germ cells and oocyte-like structures after culture in vitro Reprod. Domest. Anim, 2016-10(0).
PMID: 27925309
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2016-12-06), Regulation of hepcidin expression by inflammation-induced activin B Sci Rep, 2016-16(0):38702.
PMID: 27922109
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Atakan Tevlek (2016-11-27), Bi-layered constructs of poly(glycerol-sebacate)-?-tricalcium phosphate for bone-soft tissue interface applications Mater Sci Eng C Mater Biol Appl, 2016-172(0):316-324.
PMID: 28024592
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2016-11-11), Notch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6 Nat Commun, 2016-17(0):13247.
PMID: 27834400
Species: Rat
Sample Types: In Vivo
Applications: In Vivo

(2016-08-16), Mesenchymal stem cells from cortical bone demonstrate increased clonal incidence, potency, and developmental capacity compared to their bone marrow-derived counterparts J Tissue Eng, 2016-07(0):2041731416661.
PMID: 27579159
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Katsuhiro Hiranuma et al. (2016-07-13), Expression of nephronectin is enhanced by 1?,25-dihydroxyvitamin D3. FEBS Open Bio, 2016-00(0):2211-5463.
PMID: 27642554
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Rachel Ruoff (2016-06-16), Cell type-specific control of protein synthesis and proliferation by FGF-dependent signaling to the translation repressor 4E-BP Proc Natl Acad Sci USA, 2016-00(0).
PMID: 27313212
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

CM Karner et al. (2016-04-20), Wnt Protein Signaling Reduces Nuclear Acetyl-CoA Levels to Suppress Gene Expression during Osteoblast Differentiation J. Biol. Chem., 2016-0291(25):13028-39.
PMID: 27129247
Species: Transgenic Mouse
Sample Types: Recombinant Protein
Applications: Bioassay

Chang C et al. (2015-09-17), Osteogenic Surface Modification Based on Functionalized Poly-P-Xylylene Coating. PLoS ONE, 2015-010(9):e0137017.
PMID: 26379273
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cruet-Hennequart S et al. (2015-04-02), Radiation-induced alterations of osteogenic and chondrogenic differentiation of human mesenchymal stem cells. PLoS ONE, 2015-010(3):e0119334.
PMID: 25837977
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Westhrin M et al. (2015-03-13), Osteogenic differentiation of human mesenchymal stem cells in mineralized alginate matrices. PLoS ONE, 2015-010(3):e0120374.
PMID: 25769043
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Nio-Kobayashi J et al. (2015-01-30), Bone morphogenetic proteins are mediators of luteolysis in the human corpus luteum. Endocrinology, 2015-0156(4):1494-503.
PMID: 25635621
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Malhotra et al. (2015-01-20), Inhibition of bone morphogenetic protein signal transduction prevents the medial vascular calcification associated with matrix Gla protein deficiency. PLoS ONE, 2015-010(1):e0117098.
PMID: 25603410
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Alberton P et al. (2014-12-10), Loss of tenomodulin results in reduced self-renewal and augmented senescence of tendon stem/progenitor cells. Stem Cells Dev, 2014-124(5):597-609.
PMID: 25351164
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Hill C et al. (2014-12-01), Type III transforming growth factor beta receptor regulates vascular and osteoblast development during palatogenesis. Dev Dyn, 2014-1244(2):122-33.
PMID: 25382630
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Prewitt A et al. (2014-11-19), Heterozygous null bone morphogenetic protein receptor type 2 mutations promote SRC kinase-dependent caveolar trafficking defects and endothelial dysfunction in pulmonary arterial hypertension. J Biol Chem, 2014-1290(2):960-71.
PMID: 25411245
Species: Chicken, Mouse
Sample Types: Whole Cells
Applications: Bioassay

Yang X et al. (2014-10-20), Matrilin-3 inhibits chondrocyte hypertrophy as a bone morphogenetic protein-2 antagonist. J Biol Chem, 2014-1289(50):34768-79.
PMID: 25331953
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Tanwar V et al. (2014-07-01), Gremlin 2 promotes differentiation of embryonic stem cells to atrial fate by activation of the JNK signaling pathway. Stem Cells, 2014-032(7):1774-88.
PMID: 24648383
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Bizen N et al. (2014-06-01), A growth-promoting signaling component cyclin D1 in neural stem cells has antiastrogliogenic function to execute self-renewal. Stem Cells, 2014-032(6):1602-15.
PMID: 24302516
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Park J et al. (2014-04-30), Cooperativity of E-cadherin and Smad4 loss to promote diffuse-type gastric adenocarcinoma and metastasis. Mol Cancer Res, 2014-012(8):1088-99.
PMID: 24784840
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Shen et al. (2014-03-28), Tissue engineering bone using autologous progenitor cells in the peritoneum. PLoS ONE, 2014-09(3):e93514.
PMID: 24681529
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Okamoto M et al. (2014-03-27), Noncanonical Wnt5a enhances Wnt/beta-catenin signaling during osteoblastogenesis. Sci Rep, 2014-04(0):4493.
PMID: 24670389
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Dussiot M et al. (2014-03-23), An activin receptor IIA ligand trap corrects ineffective erythropoiesis in beta-thalassemia. Nat Med, 2014-020(4):398-407.
PMID: 24658077
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Heinonen A et al. (2014-03-11), Neuroprotection by rAAV-mediated gene transfer of bone morphogenic protein 7. BMC Neurosci, 2014-015(0):38.
PMID: 24618040
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Abdel Aziz M et al. (2014-03-09), The role of bone marrow derived-mesenchymal stem cells in attenuation of kidney function in rats with diabetic nephropathy. Diabetol Metab Syndr, 2014-06(1):34.
PMID: 24606996
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Todaro M et al. (2014-03-06), CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis. Cell Stem Cell, 2014-014(3):342-56.
PMID: 24607406
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

An J et al. (2014-03-01), Changes of microRNA profile and microRNA-mRNA regulatory network in bones of ovariectomized mice. J Bone Miner Res, 2014-029(3):644-56.
PMID: 23929739
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Wolf S et al. (2014-02-27), Identification of BMP2 as an epigenetically silenced growth inhibitor in rhabdomyosarcoma. Int J Oncol, 2014-044(5):1727-35.
PMID: 24585058
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Gao X et al. (2014-02-21), Bone morphogenetic protein signaling protects against cerulein-induced pancreatic fibrosis. PLoS ONE, 2014-09(2):e89114.
PMID: 24586530
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Suresh Babu S et al. (2014-02-20), TGFbeta-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells. BMC Cancer, 2014-014(0):113.
PMID: 24555435
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ratnayake M et al. (2014-01-21), Human chondrocytes respond discordantly to the protein encoded by the osteoarthritis susceptibility gene GDF5. PLoS ONE, 2014-09(1):e86590.
PMID: 24466161
Species: Hamster
Sample Types: Whole Cells
Applications: Bioassay

Hang et al. (2013-12-12), Asparagine-linked glycosylation of bone morphogenetic protein-2 is required for secretion and osteoblast differentiation. Glycobiology, 2013-124(3):292-304.
PMID: 24336949
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Brady K et al. (2013-12-04), Human fetal and adult bone marrow-derived mesenchymal stem cells use different signaling pathways for the initiation of chondrogenesis. Stem Cells Dev, 2013-123(5):541-54.
PMID: 24172175
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Garrel G et al. (2013-11-18), Unsaturated fatty acids disrupt Smad signaling in gonadotrope cells leading to inhibition of FSHbeta gene expression. Endocrinology, 2013-1155(2):592-604.
PMID: 24248462
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Clementi C et al. (2013-11-14), Activin-like kinase 2 functions in peri-implantation uterine signaling in mice and humans. PLoS Genet, 2013-19(11):e1003863.
PMID: 24244176
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Gao L et al. (2013-10-21), TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages. J Cell Sci, 2013-1126(0):5704-13.
PMID: 24144697
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Kawamoto T et al. (2013-10-16), Generation of robust vascular networks from cardiovascular blast populations derived from human induced pluripotent stem cells in vivo and ex vivo organ culture system. Biochem Biophys Res Commun, 2013-1441(1):180-5.
PMID: 24140407
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Laperrousaz B et al. (2013-10-07), Primitive CML cell expansion relies on abnormal levels of BMPs provided by the niche and on BMPRIb overexpression. Blood, 2013-1122(23):3767-77.
PMID: 24100446
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Talavera-Adame et al. (2013-09-24), Bone morphogenetic protein-2/-4 upregulation promoted by endothelial cells in coculture enhances mouse embryoid body differentiation. Stem Cells Dev, 2013-022(24):3252-60.
PMID: 23924071
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Hwang J et al. (2013-09-19), Protein phosphatase 2A isoforms utilizing Abeta scaffolds regulate differentiation through control of Akt protein. J Biol Chem, 2013-0288(44):32064-73.
PMID: 24052256
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Aubert-Foucher E et al. (2013-09-17), A unique tool to selectively detect the chondrogenic IIB form of human type II procollagen protein. Matrix Biol, 2013-034(0):80-8.
PMID: 24055103
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Koskinen C et al. (2013-08-29), Lack of CD47 impairs bone cell differentiation and results in an osteopenic phenotype in vivo due to impaired signal regulatory protein alpha (SIRPalpha) signaling. J Biol Chem, 2013-0288(41):29333-44.
PMID: 23990469
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Gadi et al. (2013-07-25), The transcription factor protein Sox11 enhances early osteoblast differentiation by facilitating proliferation and the survival of mesenchymal and osteoblast progenitors. J Biol Chem, 2013-0288(35):25400-13.
PMID: 23888050
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Deschaseaux F et al. (2013-04-16), Regulation and function of immunosuppressive molecule human leukocyte antigen G5 in human bone tissue. FASEB J, 2013-027(8):2977-87.
PMID: 23592762
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Wang et al. (2013-04-01), Endocardial to myocardial notch-wnt-bmp axis regulates early heart valve development. PLoS ONE, 2013-08(4):e60244.
PMID: 23560082
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Li S et al. (2013-03-25), Integration of multiple signaling regulates through apoptosis the differential osteogenic potential of neural crest-derived and mesoderm-derived Osteoblasts. PLoS ONE, 2013-08(3):e58610.
PMID: 23536803
Species: Bovine
Sample Types: Whole Cells
Applications: Bioassay

Glister C et al. (2013-03-25), Functional link between bone morphogenetic proteins and insulin-like peptide 3 signaling in modulating ovarian androgen production. Proc Natl Acad Sci U S A, 2013-0110(15):E1426-35.
PMID: 23530236
Species: Mouse
Sample Types: Embryo
Applications: In Vivo

Yamamoto-Shiraishi Y et al. (2013-03-13), Wnt and BMP signaling cooperate with Hox in the control of Six2 expression in limb tendon precursor. 2013-00(0).
PMID: 23499659
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Huegel J et al. (2013-03-01), Perichondrium phenotype and border function are regulated by Ext1 and heparan sulfate in developing long bones: a mechanism likely deranged in Hereditary Multiple Exostoses. Dev Biol, 2013-0377(1):100-12.
PMID: 23458899
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Narayanan et al. (2013-02-06), Human embryonic stem cells differentiate into functional renal proximal tubular-like cells. Kidney Int, 2013-083(4):593-603.
PMID: 23389418
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Akiyama H et al. (2013-01-21), A novel adipokine C1q/TNF-related protein 1 (CTRP1) regulates chondrocyte proliferation and maturation through the ERK1/2 signaling pathway. Mol Cell Endocrinol, 2013-0369(1):63-71.
PMID: 23348620
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Chen et al. (2012-12-02), H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs. Nat Genet, 2012-145(1):34-42.
PMID: 23202127
Species: Human
Sample Types: Recombinant Protein
Applications: Surface Plasmon Resonance

Wu et al. (2012-09-27), Repulsive guidance molecule (RGM) family proteins exhibit differential binding kinetics for bone morphogenetic proteins (BMPs). PLoS ONE, 2012-07(9):e46307.
PMID: 23029472
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Satomi-Kobayashi S et al. (2012-07-09), Osteoblast-like differentiation of cultured human coronary artery smooth muscle cells by bone morphogenetic protein endothelial cell precursor-derived regulator (BMPER). J Biol Chem, 2012-0287(36):30336-45.
PMID: 22778264
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay

Bruce D et al. (2012-07-07), Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-beta pathway. Cell Signal, 2012-024(11):1999-2006.
PMID: 22781750
Species: Human
Sample Types: Recombinant Protein
Applications: Binding Assay

Kim M et al. (2012-04-13), Gremlin-1 induces BMP-independent tumor cell proliferation, migration, and invasion. PLoS ONE, 2012-07(4):e35100.
PMID: 22514712
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Asumda FZ et al. (2011-10-12), Age-related changes in rat bone-marrow mesenchymal stem cell plasticity. BMC Cell Biol., 2011-112(0):44.
PMID: 21992089
Species: Human, Mouse
Sample Types: Recombinant Protein
Applications: Surface Plasmon Resonance

Castonguay R et al. (2011-07-07), Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth. J. Biol. Chem., 2011-0286(34):30034-46.
PMID: 21737454
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Geens M et al. (2011-02-12), Sertoli cell-conditioned medium induces germ cell differentiation in human embryonic stem cells. J. Assist. Reprod. Genet., 2011-00(0).
PMID: 21318592
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Dalfino G et al. (2010-04-29), Bone morphogenetic protein-2 may represent the molecular link between oxidative stress and vascular stiffness in chronic kidney disease. Atherosclerosis, 2010-0211(2):418-23.
PMID: 20537331
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Haupt LM et al. (2009-09-01), The heparan sulfate proteoglycan (HSPG) glypican-3 mediates commitment of MC3T3-E1 cells toward osteogenesis. J. Cell. Physiol., 2009-0220(3):780-91.
PMID: 19479939
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Tanno T et al. (2009-05-04), Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells. Blood, 2009-0114(1):181-6.
PMID: 19414861
Species: Zebrafish
Sample Types: Whole Tissue
Applications: Bioassay

Little SC et al. (2009-04-19), Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis. Nat. Cell Biol., 2009-011(5):637-43.
PMID: 19377468
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Irie N et al. (2009-03-19), Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis. J. Biol. Chem., 2009-0284(21):14637-44.
PMID: 19299512
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Shafer SL et al. (2009-01-21), Transcriptional regulation of SM22alpha by Wnt3a: convergence with TGFbeta(1)/Smad signaling at a novel regulatory element. J. Mol. Cell. Cardiol., 2009-046(5):621-35.
PMID: 19344627
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Tseng YH et al. (2008-08-21), New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature, 2008-0454(7207):1000-4.
PMID: 18719589
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Jeanpierre S et al. (2008-07-29), BMP4 regulation of human megakaryocytic differentiation is involved in thrombopoietin signaling. Blood, 2008-0112(8):3154-63.
PMID: 18664625
Species: Human
Sample Types: Recombinant Protein
Applications: ELISA (Capture), Surface Plasmon Resonance

Sengle G et al. (2008-07-02), A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7. J. Mol. Biol., 2008-0381(4):1025-39.
PMID: 18621057
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kane R et al. (2008-06-20), Chordin-like 1, a bone morphogenetic protein-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating angiogenesis. Mol. Vis., 2008-014(0):1138-48.
PMID: 18587495
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Desbordes SC et al. (2008-06-05), High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Cell Stem Cell, 2008-02(6):602-12.
PMID: 18522853
Species: Human
Sample Types: Recombinant Protein
Applications: Binding Assay, Surface Plasmon Resonance

Sengle G et al. (2008-03-13), Targeting of bone morphogenetic protein growth factor complexes to fibrillin. J. Biol. Chem., 2008-0283(20):13874-88.
PMID: 18339631
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Southwood M et al. (2008-01-01), Regulation of bone morphogenetic protein signalling in human pulmonary vascular development. J. Pathol., 2008-0214(1):85-95.
PMID: 17992660
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Pi X et al. (2007-12-24), Sequential roles for myosin-X in BMP6-dependent filopodial extension, migration, and activation of BMP receptors. J. Cell Biol., 2007-1179(7):1569-82.
PMID: 18158328
Species: Xenopus
Sample Types: Whole Cells
Applications: Bioassay

Hocking JC et al. (2007-10-05), TGFbeta ligands promote the initiation of retinal ganglion cell dendrites in vitro and in vivo. Mol. Cell. Neurosci., 2007-137(2):247-60.
PMID: 17997109
Species: Xenopus
Sample Types: Whole Cells
Applications: Bioassay

Wen Z et al. (2007-07-02), BMP gradients steer nerve growth cones by a balancing act of LIM kinase and Slingshot phosphatase on ADF/cofilin. J. Cell Biol., 2007-0178(1):107-19.
PMID: 17606869
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Niki Y et al. (2007-07-01), Administration of cyclooxygenase-2 inhibitor reduces joint inflammation but exacerbates osteopenia in IL-1 alpha transgenic mice due to GM-CSF overproduction. J. Immunol., 2007-0179(1):639-46.
PMID: 17579086
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay

Tesar PJ et al. (2007-06-27), New cell lines from mouse epiblast share defining features with human embryonic stem cells. Nature, 2007-0448(7150):196-9.
PMID: 17597760
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Lin L et al. (2007-05-31), Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. Blood, 2007-0110(6):2182-9.
PMID: 17540841
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ungefroren H et al. (2007-04-15), Antitumor activity of ALK1 in pancreatic carcinoma cells. Int. J. Cancer, 2007-0120(8):1641-51.
PMID: 17230504
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Diarra D et al. (2007-01-21), Dickkopf-1 is a master regulator of joint remodeling. Nat. Med., 2007-013(2):156-63.
PMID: 17237793
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Zhu J et al. (2007-01-16), Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells. Blood, 2007-0109(9):3706-12.
PMID: 17227831
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Gossrau G et al. (2007-01-11), Bone morphogenetic protein-mediated modulation of lineage diversification during neural differentiation of embryonic stem cells. Stem Cells, 2007-025(4):939-49.
PMID: 17218404
Species: Canine, Human
Sample Types: Whole Cells
Applications: Bioassay

Bartunek J et al. (2006-10-20), Pretreatment of adult bone marrow mesenchymal stem cells with cardiomyogenic growth factors and repair of the chronically infarcted myocardium. Am. J. Physiol. Heart Circ. Physiol., 2006-1292(2):H1095-104.
PMID: 17056665
Species: Bovine, Human
Sample Types: Whole Cells
Applications: Bioassay

Yao Y et al. (2006-09-27), Activin-like kinase receptor 1 (ALK1) in atherosclerotic lesions and vascular mesenchymal cells. Cardiovasc. Res., 2006-074(2):279-89.
PMID: 17074310
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Lindsley RC et al. (2006-08-30), Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm. Development, 2006-0133(19):3787-96.
PMID: 16943279
Species: Rabbit
Sample Types: In Vivo
Applications: In Vivo

Liu HW et al. (2006-06-16), Targeted delivery system for juxtacrine signaling growth factor based on rhBMP-2-mediated carrier-protein conjugation. Bone, 2006-039(4):825-36.
PMID: 16782421
Species: Chicken
Sample Types: In Vivo
Applications: In Vivo

Bonafede A et al. (2006-06-15), BMPs restrict the position of premuscle masses in the limb buds by influencing Tcf4 expression. Dev. Biol., 2006-0299(2):330-44.
PMID: 17005177
Species: Rat
Sample Types: Whole Tissue
Applications: Bioassay

Maeshima A et al. (2006-04-27), Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct. Dev. Biol., 2006-0295(2):473-85.
PMID: 16643884
Species: Chicken
Sample Types: Whole Tissue
Applications: Bioassay

Schlueter J et al. (2006-04-01), BMP is an important regulator of proepicardial identity in the chick embryo. Dev. Biol., 2006-0295(2):546-58.
PMID: 16677627
Species: Rat
Sample Types: In Vivo
Applications: In Vivo

Hong SJ et al. (2006-03-29), The effect of a fibrin-fibronectin/beta-tricalcium phosphate/recombinant human bone morphogenetic protein-2 system on bone formation in rat calvarial defects. Biomaterials, 2006-027(20):3810-6.
PMID: 16574220
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Ando T et al. (2006-01-01), TWEAK/Fn14 interaction regulates RANTES production, BMP-2-induced differentiation, and RANKL expression in mouse osteoblastic MC3T3-E1 cells. Arthritis Res. Ther., 2006-08(5):R146.
PMID: 16945157
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Blair DG et al. (2004-11-15), Cutting edge: bone morphogenetic protein antagonists Drm/Gremlin and Dan interact with Slits and act as negative regulators of monocyte chemotaxis. J. Immunol., 2004-1173(10):5914-7.
PMID: 15528323
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Knosp WM et al. (2004-09-01), HOXA13 regulates the expression of bone morphogenetic proteins 2 and 7 to control distal limb morphogenesis. Development, 2004-0131(18):4581-92.
PMID: 15342482
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Binnerts ME et al. (2004-03-05), Human Crossveinless-2 is a novel inhibitor of bone morphogenetic proteins. Biochem. Biophys. Res. Commun., 2004-0315(2):272-80.
PMID: 14766204
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Moser M et al. (2003-08-01), BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation. Mol. Cell. Biol., 2003-023(16):5664-79.
PMID: 12897139
Species: Rabbit
Sample Types: Whole Cells
Applications: Bioassay

Lee YM et al. (2003-06-01), Enhanced bone augmentation by controlled release of recombinant human bone morphogenetic protein-2 from bioabsorbable membranes. J. Periodontol., 2003-074(6):865-72.
PMID: 12886998

There are no citations that match your criteria.

Showing 1 - 10 of 185 citations Showing All

Customer Reviews for Recombinant Human/Mouse/Rat BMP-2 Protein (11)

4.8 out of 5

11 customer ratings

5 stars

82%

4 stars

18%

3 stars

2 stars

1 star

Customer Images

Showing 1 - 5 of 11 reviews Showing All

Filter By:

Recombinant Human/Mouse/Rat BMP-2 Protein

Name: Anonymous

Application: Enzymatic activity in vitro

Reason for Rating: 50 ng/ml works well to induce osteoblast differentiation.

Verified Customer | Posted 04/05/2022
Recombinant Human/Mouse/Rat BMP-2 Protein

Name: zeji du

Application: Stem/Immune cell maintenance or differentiation

Reason for Rating: I used it for osteoblasts differentiation, Arizarin staining.It keeps and promotes osteoblasts mineralization very well.

Verified Customer | Posted 05/27/2021
Recombinant Human/Mouse/Rat BMP-2 Protein

Name: Anonymous

Application: In vitro bioactivity in cell culture

Reason for Rating: I used BMP2 to activate BMP reporter and it worked very well.

Verified Customer | Posted 09/15/2020
Recombinant Human/Mouse/Rat BMP-2 Protein

Name: Anonymous

Application: CellProlif

Reason for Rating: Another great product made by R&D Systems. Always produces consistent and reliable results. Great as a control.

Verified Customer | Posted 10/09/2019
Recombinant Human/Mouse/Rat BMP-2 Protein

Name: Anonymous

Application: Immunofluorescence

Verified Customer | Posted 10/26/2018
Recombinant Human/Mouse/Rat BMP-2 Protein

Name: Cody Saylor

Application: In vitro bioactivity in cell culture

Reason for Rating: Performed as expected to force differentiation of C2C12's to Osteoblasts

Verified Customer | Posted 09/07/2017
Name: Abby Sukarto

Verified Customer | Posted 05/03/2017
Recombinant Human/Mouse/Rat BMP-2 Protein

Name: Javier Aragón

Application: BMP-2 Delivery System

Verified Customer | Posted 01/05/2017
Recombinant Human/Mouse/Rat BMP-2 Protein

Name: Anonymous

Application: Binding assay/Protein-protein interaction

Reason for Rating: Materials performed as expected.

Verified Customer | Posted 05/13/2016
Recombinant Human/Mouse/Rat BMP-2 Protein

Name: Frank Grosso

Application: Binding assay/Protein-protein interaction

Reason for Rating: This protein performed exactly as expected.

Verified Customer | Posted 01/15/2016
Recombinant Human/Mouse/Rat BMP-2 Protein

Name: Anonymous

Sample Tested: C2C12 mouse myoblast cell line

Verified Customer | Posted 10/26/2015

ALP assay measuring osteogenic induction of C2C12 cells treated with BMP-2.

There are no reviews that match your criteria.

Showing 1 - 5 of 11 reviews Showing All

FAQs for Recombinant Human/Mouse/Rat BMP-2 Protein

What is the difference between the two Recombinant Human/Mouse/Rat BMP-2 Proteins (Catalog # 355-BM and 355-BEC)?

Catalog # 355-BM is produced in a mammalian system using CHO cells and exhibits better activity in our routine QC bioassay, while Catalog # 355-BEC is produced in an E. coli expression system and is less expensive. Bioactivity of both Human/Mouse/Rat BMP-2 Proteins is measured in an alkaline phosphatase assay using by ATDC5 mouse chondrogenic cells. For 355-BM, the ED50 for this effect is 40-200 ng/mL, while for 355-BEC, the ED50 range is 80-480 ng/mL. We recommend reviewing our list of publications under the Citations tab for both 355-BM and 355-BEC to determine which of the two proteins is most suitable for your experiment.
What is the sequence homology between human, mouse and rat BMP-2

Mature human BMP-2 shares 100% aa sequence identity with mouse and rat BMP-2.
Does Recombinant Human/Mouse/Rat BMP-2 Protein (Catalog # 355-BM) have a histidine tag?

Recombinant Human/Mouse/Rat BMP-2 Protein (Catalog # 355-BM) does not contain a histidine tag. The sequence of this protein contains Gln283-Arg396 aa based on Accession # P12643.

Recombinant Human/Mouse/Rat BMP-2 Protein

Catalog # 355-BM | R&D Systems, Inc. a Bio-Techne Brand

Key Product Details

Product Specifications for Recombinant Human/Mouse/Rat BMP-2 Protein

Scientific Data Examples for Recombinant Human/Mouse/Rat BMP-2 Protein

Formulation, Preparation and Storage

Carrier Free

355-BM

Carrier

355-BM/CF

Carrier Free

Reconstitution Calculator

Background: BMP-2

Citations for Recombinant Human/Mouse/Rat BMP-2 Protein (185)

Customer Reviews for Recombinant Human/Mouse/Rat BMP-2 Protein (11)

Customer Images

Recombinant Human/Mouse/Rat BMP-2 Protein

Recombinant Human/Mouse/Rat BMP-2 Protein

Recombinant Human/Mouse/Rat BMP-2 Protein

Recombinant Human/Mouse/Rat BMP-2 Protein

Recombinant Human/Mouse/Rat BMP-2 Protein

Recombinant Human/Mouse/Rat BMP-2 Protein

Recombinant Human/Mouse/Rat BMP-2 Protein

Recombinant Human/Mouse/Rat BMP-2 Protein

Recombinant Human/Mouse/Rat BMP-2 Protein

Recombinant Human/Mouse/Rat BMP-2 Protein

FAQs for Recombinant Human/Mouse/Rat BMP-2 Protein

Product Documents for Recombinant Human/Mouse/Rat BMP-2 Protein

Product Datasheets

COA

Certificate of Analysis

SDS

Bio-Techne Brands

Stay Connected