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Recombinant Human IL-6 Protein

R&D Systems, Inc. a Bio-Techne Brand

A New rhIL-6 is Available! It is catalog # 7270-IL. The new protein has ~2 fold better activity and is HEK293 expressed!
Recombinant Human IL-6 Protein Bioactivity
(3)
Recombinant Human IL-6 Protein SDS-PAGE
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With Carrier
206-IL-01M
206-IL-050
206-IL-200
206-IL-010

Catalog #
Availability
Size / Price
Qty
Carrier Free
206-IL-050/CF
206-IL-001MG/CF
206-IL-200/CF
206-IL-025/CF
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Key Product Details

Source: E. coli
Accession #: Q75MH2
Applications: Bioactivity

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Citations for Recombinant Human IL-6 Protein (339)

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Customer Reviews for Recombinant Human IL-6 Protein (23)

4.7 out of 5
23 customer ratings
5 stars
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4 stars
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3 stars
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  • Recombinant Human IL-6 Protein
    Name: Anonymous
    Application: CellProlif
    Verified Customer | Posted 01/17/2022
    Recombinant Human IL-6 Protein Cell Proliferation 206-IL
  • Recombinant Human IL-6 Protein
    Name: Anonymous
    Application: In vitro bioactivity in cell culture
    Verified Customer | Posted 08/07/2021
  • Recombinant Human IL-6 Protein
    Name: Anonymous
    Application: CellProlif
    Verified Customer | Posted 05/24/2021
  • Recombinant Human IL-6 Protein
    Name: Anonymous
    Application: In vitro bioactivity in cell culture
    Verified Customer | Posted 03/06/2021
  • Recombinant Human IL-6 Protein
    Name: Anonymous
    Application: Assay validation
    Verified Customer | Posted 02/09/2021
  • Recombinant Human IL-6 Protein
    Name: tehyeon kim
    Application: CellProlif
    Verified Customer | Posted 01/17/2020
  • Recombinant Human IL-6 Protein
    Name: Anonymous
    Application: In vitro bioactivity in cell culture
    Verified Customer | Posted 01/10/2020
  • Name: Anonymous
    Application: CellProlif
    Verified Customer | Posted 02/25/2019
  • Recombinant Human IL-6 Protein
    Name: Zoia Levashova
    Application: MSD assay
    Verified Customer | Posted 11/26/2018
    The recombinant human IL-6 protein was used as the calibration reagent in MSD assay with biotinylated MAB206 (capture) and Sulfo-Tag labeled AF-206-NA (detection) antibodies.
    Recombinant Human IL-6 Protein Other 206-IL
  • Name: Anonymous
    Application: In vitro bioactivity in cell culture
    Verified Customer | Posted 10/08/2018
  • Recombinant Human IL-6 Protein
    Name: Anonymous
    Application: CellProlif
    Verified Customer | Posted 05/11/2018
  • Recombinant Human IL-6 Protein
    Name: Anonymous
    Application: CellProlif
    Verified Customer | Posted 03/02/2018
    Recombinant Human IL-6 Protein Cell Proliferation 206-IL
  • Recombinant Human IL-6 Protein
    Name: Anonymous
    Application: In vitro bioactivity in cell culture
    Verified Customer | Posted 02/11/2018
  • Recombinant Human IL-6 Protein
    Name: Anonymous
    Application: In vitro bioactivity in cell culture
    Verified Customer | Posted 06/28/2017
  • Name: Boubacar Barry
    Application: In vitro bioactivity in cell culture
    Verified Customer | Posted 06/01/2017
  • Name: Anonymous
    Application: Cell migration/motility
    Verified Customer | Posted 05/23/2017
  • Recombinant Human IL-6 Protein
    Name: Michelle Chen
    Application: In vitro bioactivity in cell culture
    Verified Customer | Posted 04/26/2017
  • Recombinant Human IL-6 Protein
    Name: Anonymous
    Application: Stem/Immune cell maintenance or differentiation
    Verified Customer | Posted 12/15/2016
    Elevated levels of the proinflammatory cytokine IL-6 are associated with poor survival outcomes in many cancers. Antibodies targeting IL-6 and its receptor have been developed for chronic inflammatory disease, but they have not yet been shown to clearly benefit cancer patients, possibly due to antibody potency or the settings in which they have been tested. In this study, we describe the development of a novel high-affinity anti-IL-6 antibody, MEDI5117, which features an extended half-life and potent inhibitory effects on IL-6 biologic activity. MEDI5117 inhibited IL-6-mediated activation of STAT3, suppressing the growth of several tumor types driven by IL-6 autocrine signaling. In the same models, MEDI5117 displayed superior preclinical activity relative to a previously developed anti-IL-6 antibody. Consistent with roles for IL-6 in promoting tumor angiogenesis, we found that MEDI5117 inhibited the growth of endothelial cells, which can produce IL-6 and support tumorigenesis. Notably, in tumor xenograft assays.
  • Recombinant Human IL-6 Protein
    Name: Veronica Fregoso
    Application: In vitro bioactivity in cell culture
    Verified Customer | Posted 08/01/2016
    Primary embryonic rat cortical cultures stimulated with IL-6 (20, 30, 40 ng/ml) for 30 minutes (PBS+BSA:negative stimulation control; Okadaic Acid, OA: positive phosphorylation control). Western blot for changes in Akt phosphorylation. *Note membranes for western were cut between 70kd and 50kd*
    Recombinant Human IL-6 Protein In vitro bioactivity in cell culture 206-IL
  • Recombinant Human IL-6 Protein
    Name: Kyle Blackshere
    Application: In vivo study
    Verified Customer | Posted 07/29/2016
  • Recombinant Human IL-6 Protein
    Name: deborah webb
    Application: Immunoassay Standard
    Verified Customer | Posted 05/16/2016
  • Recombinant Human IL-6 Protein
    Name: SOjan Abraham
    Application: In vitro bioactivity in cell culture
    Verified Customer | Posted 01/21/2016
  • Recombinant Human IL-6 Protein
    Name: Anonymous
    Application: Immunoassay Standard
    Verified Customer | Posted 01/19/2016

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FAQs for Recombinant Human IL-6 Protein

  • Can Recombinant Human IL-6 protein (Catalog # 206-IL) be used on mouse cells?

    We evaluate the bioactivity of Recombinant Human IL-6 Protein (Catalog # 206-IL) in a cell proliferation assay using mouse plasmacytoma cells during QC testing. Catalog # 206-IL exhibits an ED50 in the range of 0.2-0.8 ng/mL in this assay using mouse cells. We have evaluated the human and mouse IL-6 proteins in the same assay and found the Recombinant Mouse IL-6 Protein (Catalog # 406-ML) was more active with mouse cells. This information can be found in the activity section on the respective product datasheets. 

  • What are the differences between Recombinant Human IL-6 Protein (Catalog # 206-IL) and Recombinant Human IL-6 (HEK293-expressed) Protein (Catalog # 7270-IL)?

    Recombinant Human IL-6 Protein (Catalog # 206-IL) is raised in E. coli. The Recombinant Human IL-6 (HEK293-expressed) Protein (Catalog # 7270-IL) is raised in HEK293. Because #7270-IL is raised in mammalian cells, it is expected to have post translational modifications that are absent in the E. coli-derived version (206-IL). The HEK293-derived #7270-IL exhibits greater activity than the E. coli-derived #206-IL in the same activity assay.

Product Documents for Recombinant Human IL-6 Protein

Certificate of Analysis

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