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Recombinant Human IL-6 Protein

A New rh IL-6 is Available! The new protein has ~2 fold better activity and is HEK293 expressed!
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Key Product Details

Source: E. coli
Accession #: Q75MH2
Applications: Bioactivity

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Citations (309)

Citations are publications that use Bio-techne products. Selected citations for Recombinant Human IL-6 Protein include:

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  • Recombinant Human IL-6 Protein
    Name: Anonymous | 17th Jan 2020
    Application: CellProlif
  • Recombinant Human IL-6 Protein
    Name: Anonymous | 10th Jan 2020
    Application: In vitro bioactivity in cell culture
  • Recombinant Human IL-6 Protein
    Name: Anonymous | 25th Feb 2019
    Application: CellProlif
  • Recombinant Human IL-6 Protein
    Name: Anonymous | 26th Nov 2018
    Application: MSD assay
    The recombinant human IL-6 protein was used as the calibration reagent in MSD assay with biotinylated MAB206 (capture) and Sulfo-Tag labeled AF-206-NA (detection) antibodies.
    Recombinant Human IL-6 Protein MSD assay 206-IL
  • Recombinant Human IL-6 Protein
    Name: Anonymous | 8th Oct 2018
    Application: In vitro bioactivity in cell culture
  • Recombinant Human IL-6 Protein
    Name: Anonymous | 11th May 2018
    Application: CellProlif
  • Recombinant Human IL-6 Protein
    Name: Anonymous | 2nd Mar 2018
    Application: CellProlif
    Recombinant Human IL-6 Protein Cell Proliferation 206-IL
  • Recombinant Human IL-6 Protein
    Name: Anonymous | 11th Feb 2018
    Application: In vitro bioactivity in cell culture
  • Recombinant Human IL-6 Protein
    Name: Anonymous | 28th Jun 2017
    Application: In vitro bioactivity in cell culture
  • Recombinant Human IL-6 Protein
    Name: Anonymous | 1st Jun 2017
    Application: In vitro bioactivity in cell culture
  • Recombinant Human IL-6 Protein
    Name: Anonymous | 23rd May 2017
    Application: Cell migration/motility
  • Recombinant Human IL-6 Protein
    Name: Anonymous | 26th Apr 2017
    Application: In vitro bioactivity in cell culture
  • Recombinant Human IL-6 Protein
    Name: Anonymous | 15th Dec 2016
    Application: Stem/Immune cell maintenance or differentiation
    Elevated levels of the proinflammatory cytokine IL-6 are associated with poor survival outcomes in many cancers. Antibodies targeting IL-6 and its receptor have been developed for chronic inflammatory disease, but they have not yet been shown to clearly benefit cancer patients, possibly due to antibody potency or the settings in which they have been tested. In this study, we describe the development of a novel high-affinity anti-IL-6 antibody, MEDI5117, which features an extended half-life and potent inhibitory effects on IL-6 biologic activity. MEDI5117 inhibited IL-6-mediated activation of STAT3, suppressing the growth of several tumor types driven by IL-6 autocrine signaling. In the same models, MEDI5117 displayed superior preclinical activity relative to a previously developed anti-IL-6 antibody. Consistent with roles for IL-6 in promoting tumor angiogenesis, we found that MEDI5117 inhibited the growth of endothelial cells, which can produce IL-6 and support tumorigenesis. Notably, in tumor xenograft assays.
  • Recombinant Human IL-6 Protein
    Name: Anonymous | 1st Aug 2016
    Application: In vitro bioactivity in cell culture
    Primary embryonic rat cortical cultures stimulated with IL-6 (20, 30, 40 ng/ml) for 30 minutes (PBS+BSA:negative stimulation control; Okadaic Acid, OA: positive phosphorylation control). Western blot for changes in Akt phosphorylation. *Note membranes for western were cut between 70kd and 50kd*
    Recombinant Human IL-6 Protein In vitro bioactivity in cell culture 206-IL
  • Recombinant Human IL-6 Protein
    Name: Anonymous | 29th Jul 2016
    Application: In vivo study
  • Recombinant Human IL-6 Protein
    Name: Anonymous | 16th May 2016
    Application: Immunoassay Standard
  • Recombinant Human IL-6 Protein
    Name: Anonymous | 21st Jan 2016
    Application: In vitro bioactivity in cell culture
  • Recombinant Human IL-6 Protein
    Name: Anonymous | 19th Jan 2016
    Application: Immunoassay Standard

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FAQs

  • Can Recombinant Human IL-6 protein (Catalog # 206-IL) be used on mouse cells?

    We evaluate the bioactivity of Recombinant Human IL-6 Protein (Catalog # 206-IL) in a cell proliferation assay using mouse plasmacytoma cells during QC testing. Catalog # 206-IL exhibits an ED50 in the range of 0.2-0.8 ng/mL in this assay using mouse cells. We have evaluated the human and mouse IL-6 proteins in the same assay and found the Recombinant Mouse IL-6 Protein (Catalog # 406-ML) was more active with mouse cells. This information can be found in the activity section on the respective product datasheets. 

Product Datasheets

Certificate of Analysis

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