Recombinant Human IL-37/IL-1F7 Protein, CF
Catalog # 1975-IL | R&D Systems, Inc. a Bio-Techne Brand
Key Product Details
Product Specifications
Source
Lys27-Asp192, with an N-terminal Met
Purity
Endotoxin Level
N-terminal Sequence Analysis
Predicted Molecular Mass
Activity
When Recombinant Human (rh) IL‑18 R alpha/IL‑1 R5 Fc Chimera (Catalog # 816-LR) is immobilized at 2 μg/mL (100 μL/well), the concentration of rhIL-37/IL-1F7 Chimera that produces 50% optimal binding response is 20-120 ng/mL.
Formulation, Preparation and Storage
1975-IL
Formulation | Lyophilized from a 0.2 μm filtered solution in PBS and DTT. |
Reconstitution | Reconstitute at 100 μg/mL in sterile PBS. |
Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
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Background: IL-37/IL-1F7
References
- Dinarello, C.A. and P. Bufler (2013) Sem. Immunol. 25:466.
- Boraschi, D. et al. (2011) Eur. Cytokine Netw. 22:127.
- Ding, V.A. et al. (2016) Med. Oncol. 33:68.
- Smith, D.E. et al. (2000) J. Biol Chem 275:1169.
- Kumar S. et al. (2000) J. Biol Chem 275:10308.
- Busfield S.J. et al. (2000) Genomics 66:213.
- Pan, G. et al. (2000) Cytokine 13:1.
- Nold, M.F. et al. (2010) Nat. Immunol. 11:1014.
- McNamee, E.N. et al. (2011) Proc. Natl. Acad. Sci. USA 108:16711.
- Kumar S. et al. (2002) Cytokine 18:61.
- Bufler, P. et al. (2002) Proc. Natl. Acad. Sci. USA 99:13723.
- Sharma, S. et al. (2008) J. Immunol. 180:5477.
Long Name
Alternate Names
Entrez Gene IDs
Gene Symbol
UniProt
Product Documents for Recombinant Human IL-37/IL-1F7 Protein, CF
Product Specific Notices for Recombinant Human IL-37/IL-1F7 Protein, CF
For research use only
Citations for Recombinant Human IL-37/IL-1F7 Protein, CF (7)
Citations are publications that use Bio-Techne products. Selected citations for Recombinant Human IL-37/IL-1F7 Protein, CF include:
-
Species: Mouse
Sample Types: In Vivo
Applications: In VivoN Ma et al. (2022-11-08), Interleukin-37 protects against acinar cell pyroptosis in acute pancreatitis JCI Insight, 2022-10(0).
PMID: 36166295 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayC Ye et al. (2019-10-03), Extracellular IL-37 promotes osteogenic differentiation of human bone marrow mesenchymal stem cells via activation of the PI3K/AKT signaling pathway Cell Death Dis, 2019-110(10):753.
PMID: 31582734 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayY Zhao et al. (2019-09-23), Interleukin-37 reduces inflammation and impairs phagocytosis of platelets in immune thrombocytopenia (ITP) Cytokine, 2019-0125(0):154853.
PMID: 31557634 -
Species: Mouse,Human
Sample Types: Whole Cells
Applications: BioassayL Li et al. (2019-06-14), The deubiquitinase USP13 stabilizes the anti-inflammatory receptor IL-1R8/Sigirr to suppress lung inflammation EBioMedicine, 2019-00(0).
PMID: 31204278 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayM Zhao et al. (2018-05-22), IL-37 isoform D downregulates pro-inflammatory cytokines expression in a Smad3-dependent manner Cell Death Dis, 2018-09(6):582.
PMID: 29789615 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayM Jiang et al. (2018-03-25), IL-37 inhibits invasion and metastasis in non-small cell lung cancer by suppressing the IL-6/STAT3 signaling pathway Thorac Cancer, 2018-00(0).
PMID: 29575809 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayWilson TR et al. (2012-07-26), Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 2012-0487(7408):505-9.
PMID: 22763448
There are no citations that match your criteria.
Reconstitution Calculator
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