Recombinant Human IL-2R beta Fc/IL-2R gamma Fc Protein, CF

R&D Systems, part of Bio-Techne | Catalog # 11686-2B

Fc Chimera
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11686-2B-050
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Key Product Details

  • R&D Systems CHO-derived Recombinant Human IL-2R beta Fc/IL-2R gamma Fc Protein (11686-2B)
  • Quality control testing to verify active proteins with lot specific assays by in-house scientists
  • All R&D Systems proteins are covered with a 100% guarantee

Source

CHO

Structure / Form

Disulfide-linked heterodimer

Conjugate

Unconjugated

Applications

Bioactivity

View all IL-2 R beta/IL-2 R gamma Proteins and Enzymes »

Product Specifications

Source

Chinese Hamster Ovary cell line, CHO-derived human IL-2 R beta/IL-2 R gamma protein
Human IL-2RB
(Ala27-Asp239)
Accession # P14784.1		 IEGR Human IgG1
(Glu99-Lys330)
(with modifications)
Human IL-2RG
(Leu23-Asn254)
Accession # P31785.1		 IEGR Human IgG1
(Glu99-Lys330)
(with modifications)
N-terminus C-terminus

Purity

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

Endotoxin Level

<0.10 EU per 1 μg of the protein by the LAL method.

N-terminal Sequence Analysis

Ala 27 (IL-2R beta) & Leu 23 (IL-2R gamma)

Predicted Molecular Mass

51 kDa (IL-2R beta) & 54 kDa (IL-2 R gamma)

SDS-PAGE

62-68 kDa (IL-2R beta) & 85-93 kDa (IL-2R gamma)

Activity

Measured by its binding ability in a functional ELISA.
Recombinant Human IL-2R beta Fc/IL-2R gamma Fc Heterodimer binds to Recombinant Human IL-2 Protein, CF (Catalog # BT-002) with an ED50 of 0.300-3.00 μg/mL.

Scientific Data Images for Recombinant Human IL-2R beta Fc/IL-2R gamma Fc Protein, CF

Recombinant Human IL-2R beta Fc/IL-2R gamma Fc Heterodimer Protein Binding Activity.

Measured by its binding ability in a functional ELISA. Recombinant Human IL-2R beta Fc/IL-2R gamma Fc Heterodimer Protein (Catalog # 11686-2B) binds to Recombinant Human IL-2 Protein, CF (BT-002) with an ED50 of 0.300-3.00 μg/mL.

Recombinant Human IL-2R beta Fc/IL-2R gamma Fc Heterodimer Protein SDS-PAGE.

2 μg/lane of Recombinant Human IL-2R beta Fc/IL-2R gamma Fc Heterodimer Protein (Catalog # 11686-2B) was resolved with SDS-PAGE under reducing (R) condition and visualized by Coomassie® Blue staining, showing bands at 62-68 kDa (IL-2R beta) & 85-93 kDa (IL-2R gamma).

Formulation, Preparation and Storage

11686-2B
Formulation Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Reconstitution Reconstitute at 250 μg/mL in water.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: IL-2 R beta/IL-2 R gamma

Interleukin-2 receptor subunit beta (IL-2 RB), also known as high affinity IL-2 receptor subunit beta, interleukin-15 receptor subunit beta, p70-75 (p75), and CD122, is a member of the cytokine receptor superfamily that plays a role in T cell-mediated immune responses (1, 2). Human IL-2 RB consists of an extracellular domain (ECD) containing a fibronectin type III domain and a WSXWS motif, a type I transmembrane domain, and a cytoplasmic tail. The gamma chain of the high affinity functional human IL-2 receptor complex belongs to the hematopoietin receptor family. IL-2 R gamma is a 369 amino acid residue protein consisting of a 22 residue signal sequence, a 232 residue extracellular domain, a 29 residue transmembrane domain and an 86 residue cytoplasmic domain. Functional IL-2 receptors can exist in two affinity states on cell surfaces: the high affinity complex consisting of heterotrimers of the alpha, beta, and gamma chains and the intermediate affinity complex comprising heterodimers of the beta and gamma chains (2, 3). Individual beta chains and alpha chains exhibit low affinity IL-2 binding and the gamma chain alone does not bind IL-2. In addition to their involvement in IL-2 mediated signal transduction, both the beta chain and gamma chain have been shown to be required for IL-15 mediated signaling (4). 

References

  1. Jia, Z. et al. (2019) Int. Immunpharmacol. 74:105716.
  2. Zhang, Z. et al. (2019) J. Exp. Med. 216:1311.
  3. Zhou, X. et al. (2019) Fish & Shellfish Immunol. 93:641.
  4. Fernandez, I. et al. (2019) J. Exp. Med. 216:1255.

Long Name

Interleukin 2 receptor subunit beta/Interleukin 2 receptor subunit gamma

Alternate Names

CIDX, IL-2RG, IL15RB, IMD4, IMD63, P64, SCIDX

Entrez Gene IDs

3560 (Human); 16185 (Mouse); 25746 (Rat)

Gene Symbol

IL2RB

Additional IL-2 R beta/IL-2 R gamma Products

Product Documents for Recombinant Human IL-2R beta Fc/IL-2R gamma Fc Protein, CF

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Recombinant Human IL-2R beta Fc/IL-2R gamma Fc Protein, CF

For research use only

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