Recombinant Human Axl Fc Chimera Protein, CF
Catalog # 154-AL | R&D Systems, Inc. a Bio-Techne Brand
Key Product Details
Accession #
Source
Structure / Form
Conjugate
Applications
Product Specifications
Source
Human Axl (Glu33-Pro440) Accession # AAA61243 |
DIEGRMD | Human IgG1 (Pro100-Lys330) |
6-His tag |
N-terminus | C-terminus |
Purity
Endotoxin Level
N-terminal Sequence Analysis
Predicted Molecular Mass
SDS-PAGE
Activity
When Recombinant Human Axl Fc Chimera is immobilized at 2 µg/mL (100 µL/well), the concentration of Recombinant Human Gas6 (Catalog # 885-GS) that produces 50% of the optimal binding response is approximately 2.5‑15 ng/mL.
Formulation, Preparation and Storage
154-AL
Formulation | Lyophilized from a 0.2 μm filtered solution in PBS. |
Reconstitution |
Reconstitute at 100 μg/mL in sterile PBS.
|
Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
Background: Axl
References
- Linger, R.M.A. et al. (2011) Adv. Cancer Res. 100:35.
- O’Bryan, J.P. et al. (1991) Mol. Cell. Biol. 11:5016.
- Nagata, K. et al. (1996) J. Biol. Chem. 22:30022.
- Cosemans, J.M.E.M. et al. (2010) J. Thromb. Haemost. 8:1797.
- Seitz, H.M. et al. (2007) J. Immunol. 178:5635.
- Park, I.-K. et al. (2009) Blood 113:2470.
- Holland, S. et al. (2005) Cancer Res. 65:9294.
- Rankin, E.B. et al. (2010) Cancer Res. 70:7570.
- Korshunov, V.A. et al. (2006) Circ. Res. 98:1446.
- Morizono, K. et al. (2011) Cell Host Microbe 9:286.
- O’Bryan, J.P. et al. (1995) J. Biol. Chem. 270:551.
- Ekman, C. et al. (2010) J. Thromb. Haemost. 8:838.
Long Name
Alternate Names
Gene Symbol
UniProt
Product Documents for Recombinant Human Axl Fc Chimera Protein, CF
Product Specific Notices for Recombinant Human Axl Fc Chimera Protein, CF
For research use only
Citations for Recombinant Human Axl Fc Chimera Protein, CF (12)
Citations are publications that use Bio-Techne products. Selected citations for Recombinant Human Axl Fc Chimera Protein, CF include:
-
Species: Mouse
Sample Types: Whole Cell
Applications: BioassayCA Hokanson et al. (2022-12-08), AXL-Receptor Targeted 14FN3 Based Single Domain Proteins (Pronectins�) from 3 Synthetic Human Libraries as Components for Exploring Novel Bispecific Constructs against Solid Tumors Biomedicines, 2022-110(12).
PMID: 36551940 -
Species: Human
Sample Types: Protein
Applications: SPRF Wanke et al. (2021-05-25), Ligand-dependent kinase activity of MERTK drives efferocytosis in human iPSC-derived macrophages Cell Death & Disease, 2021-012(6):538.
PMID: 34035216 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayG Luthria et al. (2020-07-14), In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells Nat Commun, 2020-011(1):3521.
PMID: 32665556 -
Species: Human
Sample Types: Whole Cells
Applications: BioassaySJ Wang et al. (2020-05-22), Efficient blockade of locally reciprocated tumor-macrophage signaling using a TAM-avid nanotherapy Sci Adv, 2020-06(21):eaaz8521.
PMID: 32494745 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayPY Dumas et al. (2019-03-28), Hematopoietic niche drives FLT3-ITD acute myeloid leukemia resistance to quizartinib via STAT5- and hypoxia- dependent up-regulation of AXL Haematologica, 2019-00(0).
PMID: 30923103 -
Species: Human
Sample Types: Whole Cells
Applications: CAR-TCho J et al. (2018-03-01), Engineering Axl specific CAR and SynNotch receptor for cancer therapy. Sci Rep, 2018-08(1):3846.
PMID: 29497107 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayPark I et al. (2015-06-19), Receptor tyrosine kinase Axl is required for resistance of leukemic cells to FLT3-targeted therapy in acute myeloid leukemia. Leukemia, 2015-029(12):2382-9.
PMID: 26172401 -
Species: Human
Sample Types: Plasma
Zizzo G et al. (2013-01-01), Circulating levels of soluble MER in lupus reflect M2c activation of monocytes/macrophages, autoantibody specificities and disease activity. Arthritis Res Ther, 2013-015(6):R212.
PMID: 24325951 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayCerchia et al. (2012-08-21), Targeting Axl with an high-affinity inhibitory aptamer. Mol Ther, 2012-020(12):2291-303.
PMID: 22910292 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayRuan GX et al. (2012-02-10), Axl is essential for VEGF-A-dependent activation of PI3K/Akt. EMBO J., 2012-031(7):1692-703.
PMID: 22327215 -
Species: Human
Sample Types: Whole Cells
Applications: Binding AssayShimojima M et al. (2011-12-07), Identification of cell surface molecules involved in dystroglycan-independent Lassa virus cell entry. J. Virol., 2011-186(4):2067-78.
PMID: 22156524 -
Species: Human
Sample Types: Whole Cells
Applications: BioassaySensi M et al. (2011-07-28), Human cutaneous melanomas lacking MITF and melanocyte differentiation antigens express a functional Axl receptor kinase. J. Invest. Dermatol., 2011-0131(12):2448-57.
PMID: 21796150
There are no citations that match your criteria.
Customer Reviews for Recombinant Human Axl Fc Chimera Protein, CF (1)
Reconstitution Calculator
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.