(S)-3,5-DHPG
Tocris Bioscience, part of Bio-Techne | Catalog # 0805
Selective group I mGlu agonist; active enantiomer of 3,5-DHPG (Cat. No. 0342)
Key Product Details
Description
Selective group I mGlu agonist; active enantiomer of 3,5-DHPG (Cat. No. 0342)
Product Description
(S)-3,5-DHPG is a selective group I mGlu receptor agonist. (S)-3,5-DHPG regulates the expression of microRNAs in mouse cerebral cortex in vivo. (S)-3,5-DHPG induces a profound depression of synaptic dopamine release in mouse cortico-striatal cells in vitro, and anxiety-like behavior in vivo in mice.Racemate also available.
Product Specifications
Molecular Weight
183.16
Formula
C8H9NO4
Storage
Desiccate at -20°C
Purity
≥98% (HPLC)
Chemical Name
(S)-3,5-Dihydroxyphenylglycine
CAS Number
162870-29-3
PubChem ID
443586
InChI Key
HOOWCUZPEFNHDT-ZETCQYMHSA-N
SMILES
OC1=CC([C@]([H])(N)C(O)=O)=CC(O)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 9.16 | 50 |
Preparing Stock Solutions
for (S)-3,5-DHPG
The following data is based on the product molecular weight 183.16
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 10.92 mL | 54.60 mL | 109.19 mL |
| 2.5 mM | 2.18 mL | 10.92 mL | 21.84 mL |
| 5 mM | 1.09 mL | 5.46 mL | 10.92 mL |
| 25 mM | 0.22 mL | 1.09 mL | 2.18 mL |
Calculators
Molarity Calculator
Dilution Calculator
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Background References
References are publications that support the biological activity of the product.
- Mercuri Long-term depression of striatal DA release induced by mGluRs via sustained hyperactivity of local cholinergic interneurons. Front Cell Neurosci. 2021 PMID: 34924961
- Lusardi Effect of (S)-3,5-DHPG on microRNA expression in mouse brain. Exp.Neurol. 2012 PMID: 22309833
- Baker Enzymatic resolution and pharmacological activity of the enantiomers of 3,5-dihydroxyphenylglycine, a metabotropic glutamate receptor agonist. Bioorg.Med.Chem.Lett.
- Wisniewski and Car (S)-3,5-DHPG: a review. CNS Drug Rev. 2002 PMID: 12070529
- Sekiyama Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Br.J.Pharmacol. 1996 PMID: 8730745
- Schoepp 3,5-Dihydroxyphenylglycine is a highly selective agonist for phosphoinositide-linked metabotropic glutamate receptors in the rat hippocampus. J.Neurochem. 1994 PMID: 8035201
Product Specific Notices for (S)-3,5-DHPG
For research use only
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