(±)-5'-Chloro-5'-deoxy-ENBA
Tocris Bioscience, part of Bio-Techne | Catalog # 3576
Highly selective A1 agonist
Key Product Details
Description
Highly selective A1 agonist
Product Description
(±)-5'-Chloro-5'-deoxy-ENBA is a highly selective adenosine A1 receptor agonist (Ki values are 0.51, 1290, 1340 and 2740 nM at A1, A3, A2A and A2B receptors respectively). Reverses formalin-induced nocifensive behavior in mice; antinociceptive.Product Specifications
Molecular Weight
379.84
Formula
C17H22ClN5O3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-Bicyclo[2.2.1]hept-2-yl-5'-chloro-5'-deoxyadenosine
CAS Number
103626-26-2
PubChem ID
42636897
InChI Key
PVJGDYDNVNCGBT-STHLEMNDSA-N
SMILES
O[C@@H]1[C@H](O)[C@@H](CCl)O[C@H]1N(C=N3)C2=C3C(NC4C5CCC(C5)C4)=NC=N2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.98 | 100 | |
| Ethanol | 37.98 | 100 |
Preparing Stock Solutions
for (±)-5'-Chloro-5'-deoxy-ENBA
The following data is based on the product molecular weight 379.84
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.63 mL | 13.16 mL | 26.33 mL |
| 5 mM | 0.53 mL | 2.63 mL | 5.27 mL |
| 10 mM | 0.26 mL | 1.32 mL | 2.63 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.53 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Franchetti N6-cycloalkyl- and N6-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine receptor with antinociceptive effects in mice. J.Med.Chem. 2009 PMID: 19317449
- Trivedi N6-bicycloalkyladenosines with unusually high potency and selectivity for the adenosine A1 receptor. J.Med.Chem. 1989 PMID: 2909748
Product Specific Notices for (±)-5'-Chloro-5'-deoxy-ENBA
For research use only
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