Tranylcypromine hydrochloride is an irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) and monoamine oxidase (MAO). Inhibits histone demethylation. In combination with CHIR 99021 (Cat. No. 4423), enables reprogramming of mouse embryonic fibroblasts transduced by only two factors, Oct4 and Klf4, into induced pluripotent stem (iPS) cells.

For more information about how Tranylcypromine hydrochloride may be used, see our protocol: Highly Efficient Generation of CiPSCs from MEFs

Product Specifications

Molecular Weight

169.65

Formula

C₉H₁₁N.HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

(±)-trans-2-Phenylcyclopropylamine hydrochloride

CAS Number

1986-47-6

PubChem ID

2723716

InChI Key

ZPEFMSTTZXJOTM-OULXEKPRSA-N

SMILES

N[C@H]1[C@H]([C@]2=CC=CC=C2)C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	16.96	100
	DMSO	16.96	100

Preparing Stock Solutions for Tranylcypromine hydrochloride

The following data is based on the product molecular weight 169.65

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.89 mL	29.47 mL	58.94 mL
5 mM	1.18 mL	5.89 mL	11.79 mL
10 mM	0.59 mL	2.95 mL	5.89 mL
50 mM	0.12 mL	0.59 mL	1.18 mL

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

Background References

References are publications that support the biological activity of the product.

Schmidt and McCafferty trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1. Biochemistry 2007 PMID: 17367163
Li Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2. Stem Cells 2009 PMID: 19839055
Lee Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. Chem.Biol. 2006 PMID: 16793513

Tranylcypromine hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 3852

Key Product Details

Description

Alternative Names

View all Monoamine Oxidase (MAO) Inhibitors »

Product Description