Mouse CLEC4E (NP_064332) VersaClone cDNA
R&D Systems, part of Bio-Techne | Catalog # RDC2696
Key Product Details
Species
Mouse
Accession Number
Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: CLEC4E
CLEC4E, also known as Mincle, is a transmembrane C-type lectin that functions as an activating innate immune receptor on monocytes, macrophages, and immature dendritic cells. Human CLEC4E binds to mycobacterial glycolipids including the immune adjuvant TDM (cord factor), its synthetic analog TDB, and GroMM. It also binds the nuclear protein SAP130 which can be released from necrotic cells and cholesterol crystals deposited in atherosclerotic plaques. Mouse CLEC4E, in contrast, does not appear to interact with TDB, GroMM, or cholesterol crystals. The fungus Fonsecaea monophora may evade immune clearance through binding to CLEC4E and suppressing IL-12 production and Th1 cell differentiation instead of promoting inflammation.
Long Name
C-type Lectin Domain Family 4, Member E
Alternate Names
CLECSF9, MINCLE
Gene Symbol
CLEC4E
UniProt
Additional CLEC4E Products
Product Documents for Mouse CLEC4E (NP_064332) VersaClone cDNA
Product Specific Notices for Mouse CLEC4E (NP_064332) VersaClone cDNA
For research use only
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