CLEC4E Products
CLEC4E, also known as Mincle, is a transmembrane C-type lectin that functions as an activating innate immune receptor on monocytes, macrophages, and immature dendritic cells. Human CLEC4E binds to mycobacterial glycolipids including the immune adjuvant TDM (cord factor), its synthetic analog TDB, and GroMM. It also binds the nuclear protein SAP130 which can be released from necrotic cells and cholesterol crystals deposited in atherosclerotic plaques.
Mouse CLEC4E, in contrast, does not appear to interact with TDB, GroMM, or cholesterol crystals. The fungus Fonsecaea monophora may evade immune clearance by binding to CLEC4E and suppressing IL-12 production and Th1 cell differentiation instead of promoting inflammation.
Products:
116 results for "CLEC4E" in Products
116 results for "CLEC4E" in Products
CLEC4E Products
CLEC4E, also known as Mincle, is a transmembrane C-type lectin that functions as an activating innate immune receptor on monocytes, macrophages, and immature dendritic cells. Human CLEC4E binds to mycobacterial glycolipids including the immune adjuvant TDM (cord factor), its synthetic analog TDB, and GroMM. It also binds the nuclear protein SAP130 which can be released from necrotic cells and cholesterol crystals deposited in atherosclerotic plaques.
Mouse CLEC4E, in contrast, does not appear to interact with TDB, GroMM, or cholesterol crystals. The fungus Fonsecaea monophora may evade immune clearance by binding to CLEC4E and suppressing IL-12 production and Th1 cell differentiation instead of promoting inflammation.
Products:
| Reactivity: | Human, Rat |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #16E3 |
| Applications: | IHC, WB, ELISA, ICC/IF, Flow |
![Western Blot: CLEC4E Antibody (16E3)BSA Free [NBP1-49311]](https://resources.bio-techne.com/images/products/CLEC4E-Antibody-16E3-Western-Blot-NBP1-49311-img0022.jpg "Western Blot: CLEC4E Antibody (16E3)BSA Free [NBP1-49311]")
Recombinant Monoclonal Antibody.
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #2455C |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #OTI2A8 |
| Applications: | IHC, WB, Flow |
![Western Blot: CLEC4E Antibody (OTI2A8) [NBP2-45629]](https://resources.bio-techne.com/images/products/CLEC4E-Antibody-2A8-Western-Blot-NBP2-45629-img0009.jpg "Western Blot: CLEC4E Antibody (OTI2A8) [NBP2-45629]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #OTI2A8 |
| Applications: | IHC, WB, Flow, CyTOF-ready |
![Western Blot: CLEC4E Antibody (OTI2A8)Azide and BSA Free [NBP2-71793]](https://resources.bio-techne.com/images/products/CLEC4E-Antibody-OTI2A8-Azide-and-BSA-Free-Western-Blot-NBP2-71793-img0001.jpg "Western Blot: CLEC4E Antibody (OTI2A8)Azide and BSA Free [NBP2-71793]")
Recombinant Monoclonal Antibody.
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #2455C |
| Applications: | Flow |
Recombinant Monoclonal Antibody.
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #2455C |
| Applications: | Flow, CyTOF-ready |
| Reactivity: | Human, Primate |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![Western Blot: CLEC4E Antibody [NBP2-27093]](https://resources.bio-techne.com/images/products/CLEC4E-Antibody-Western-Blot-NBP2-27093-img0001.jpg "Western Blot: CLEC4E Antibody [NBP2-27093]")
| Source: | CHO |
| Accession #: | Q9ULY5 |
| Applications: | BA |
| Source: | CHO |
| Accession #: | Q9R0Q8 |
| Applications: | BA |
Recombinant Monoclonal Antibody.
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #2455C |
| Applications: | Flow |
Recombinant Monoclonal Antibody.
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #2455C |
| Applications: | Flow |
Recombinant Monoclonal Antibody.
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #2455C |
| Applications: | Flow |
Recombinant Monoclonal Antibody.
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #2455C |
| Applications: | Flow |
Recombinant Monoclonal Antibody.
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #2455C |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB |
![Western Blot: CLEC4E Antibody [NBP2-13844]](https://resources.bio-techne.com/images/products/CLEC4E-Antibody-Western-Blot-NBP2-13844-img0007.jpg "Western Blot: CLEC4E Antibody [NBP2-13844]")
| Reactivity: | Human, Rat |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #16E3 |
| Applications: | IHC, WB, ELISA, ICC/IF, Flow |
| Reactivity: | Rat |
| Details: | Mouse IgG1 Monoclonal Clone #WEN43 |
| Applications: | Flow, Func |
![Western Blot: CLEC4E Overexpression Lysate [NBL1-09261]](https://resources.bio-techne.com/images/products/CLEC4E-Overexpression-Lysate-Adult-Normal-Western-Blot-NBL1-09261-img0002.jpg "Western Blot: CLEC4E Overexpression Lysate [NBL1-09261]")
| Reactivity: | Human, Rat |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #16E3 |
| Applications: | IHC, WB, ELISA, ICC/IF, Flow |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #OTI2A8 |
| Applications: | IHC, WB, Flow, CyTOF-ready |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #OTI2A8 |
| Applications: | IHC, WB, Flow, CyTOF-ready |