Human G2A/GPR132 (NP_037477) VersaClone cDNA

R&D Systems, part of Bio-Techne | Catalog # RDC0881

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Key Product Details

Species

Human

Accession Number

NP_037477

Formulation, Preparation, and Storage

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: G2A/GPR132

GPR132, also known as G2A (for G2 accumulation), is a seven transmembrane G protein-coupled receptor that is upregulated in response to DNA damage and stress. G2A is predominantly expressed in hematopoietic tissues and in hematopoietic stem cells, and it is more highly detected in pro-B cells, while lower expression is observed in immature B cells and pre-B cells. G2A is expressed throughout T cell maturation, and it is further increased in response to T-cell activation. Ectopic expression of a G2A fusion protein in NIH/3T3 fibroblasts induces a cell cycle arrest that is consistent with a block at the G2/M transition. G2A is also able to attenuate the proliferative effects of Bcr-Abl, a chimeric tyrosine kinase oncogene, suggesting that G2A possesses anti-oncogenic properties. The amino acid sequence of G2A contains a destruction box motif that is consistently observed in cyclins, where it is required for ubiquitination and proteolytic degradation.

Long Name

G2 Accumulation Protein

Alternate Names

GPR132

Entrez Gene IDs

29933 (Human); 56696 (Mouse); 314480 (Rat)

Gene Symbol

GPR132

UniProt

NP_037477

Additional G2A/GPR132 Products

Product Documents for Human G2A/GPR132 (NP_037477) VersaClone cDNA

Product Datasheets

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Product Specific Notices for Human G2A/GPR132 (NP_037477) VersaClone cDNA

For research use only

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