Human Fc gamma RIIIA/CD16a (NP_000560) VersaClone cDNA
R&D Systems, part of Bio-Techne | Catalog # RDC2817
Key Product Details
Species
Human
Accession Number
Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: Fc gamma RIIIA/CD16a
Fc gamma RIIIA/CD16a is a low/intermediate affinity activating receptor for polyvalent immune-complexed IgG. It is involved in phagocytosis, secretion of enzymes and inflammatory mediators, antibody-dependent cytotoxicity, and clearance of immune complexes. It is expressed on NK cells, T cells, monocytes, and macrophages. It is closely related to the GPI-linked Fc gamma RIIIB which is expressed on neutrophils and eosinophils. Surface expression requires interaction with an accessory chain, either the common gamma-chain or CD3 zeta. Shed forms of both Fc gamma RIIIA and Fc gamma RIIIB can be generated by proteolytic cleavage and retain binding activity. Soluble Fc gamma RIII circulates in normal plasma and is elevated in rheumatoid arthritis and in coronary artery diseases.
Long Name
Fc gamma Receptor III A
Alternate Names
CD16a, FCGR3A, FcgRIIIA
Gene Symbol
FCGR3A
UniProt
Additional Fc gamma RIIIA/CD16a Products
Product Documents for Human Fc gamma RIIIA/CD16a (NP_000560) VersaClone cDNA
Product Specific Notices for Human Fc gamma RIIIA/CD16a (NP_000560) VersaClone cDNA
For research use only
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