BI 6015
Tocris Bioscience, part of Bio-Techne | Catalog # 4641
Hepatocyte nuclear factor 4α (HNF4α) antagonist
Key Product Details
Description
Hepatocyte nuclear factor 4α (HNF4α) antagonist
Product Description
BI 6015 is a hepatocyte nuclear factor 4α (HNF4α) antagonist. Represses expression of known HNF4α target genes. Decreases HNF4α DNA binding. Exhibits cytotoxic activity in a range of tumor cell lines, including human hepatocellular carcinoma.Product Specifications
Molecular Weight
331.35
Formula
C15H13N3O4S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-Methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-1H-benzimidazole
CAS Number
93987-29-2
PubChem ID
3269393
InChI Key
ILVCPQPMRPHZSG-UHFFFAOYSA-N
SMILES
CC2=NC1=CC=CC=C1N2S(C3=C(C)C=CC([N+]([O-])=O)=C3)(=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 6.63 | 20 |
Preparing Stock Solutions
for BI 6015
The following data is based on the product molecular weight 331.35
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 15.09 mL | 75.45 mL | 150.90 mL |
| 1 mM | 3.02 mL | 15.09 mL | 30.18 mL |
| 2 mM | 1.51 mL | 7.54 mL | 15.09 mL |
| 10 mM | 0.30 mL | 1.51 mL | 3.02 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kiselyuk HNF4α antagonists discovered by a high-throughput screen for modulators of the human Ins promoter. Chem.Biol. 2012 PMID: 22840769
Product Specific Notices for BI 6015
For research use only
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