Serpin F2/alpha 2-Antiplasmin Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-90305

Novus Biologicals, part of Bio-Techne
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NBP1-90305
NBP1-90305-25ul
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Serpin F2/alpha 2-Antiplasmin Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: VPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVVLVPTHFEWNVSQVLANLSWDTLHPPLVWERPTKVRLPKLYLKHQMDLVATLSQLGLQELFQAPDLRGISEQSLVVSGVQHQSTL

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (80%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Novus Biologicals Rabbit Serpin F2/alpha 2-Antiplasmin Antibody - BSA Free (NBP1-90305) is a polyclonal antibody validated for use in IHC. Anti-Serpin F2/alpha 2-Antiplasmin Antibody: Cited in 1 publication. All Novus Biologicals antibodies are covered by our 100% guarantee.

Scientific Data Images for Serpin F2/alpha 2-Antiplasmin Antibody - BSA Free

Serpin F2/alpha 2-Antiplasmin Antibody - BSA Free Immunohistochemistry: Serpin F2/alpha 2-Antiplasmin Antibody - BSA Free [NBP1-90305]

Immunohistochemistry: Serpin F2/alpha 2-Antiplasmin Antibody - BSA Free [NBP1-90305]

Staining of human kidney shows moderate cytoplasmic positivity in cells in tubules.
Serpin F2/alpha 2-Antiplasmin Antibody - BSA Free Immunohistochemistry: Serpin F2/alpha 2-Antiplasmin Antibody - BSA Free [NBP1-90305]

Immunohistochemistry: Serpin F2/alpha 2-Antiplasmin Antibody - BSA Free [NBP1-90305]

Staining of human liver shows strong cytoplasmic positivity in hepatocytes.
Serpin F2/alpha 2-Antiplasmin Antibody - BSA Free Immunohistochemistry: Serpin F2/alpha 2-Antiplasmin Antibody - BSA Free [NBP1-90305]

Immunohistochemistry: Serpin F2/alpha 2-Antiplasmin Antibody - BSA Free [NBP1-90305]

Staining of human skeletal muscle shows moderate cytoplasmic positivity in myocytes.
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Applications for Serpin F2/alpha 2-Antiplasmin Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Serpin F2/alpha 2-Antiplasmin

Identification in human milk of complexes of matriptase with ATIII, A1AT, or A2AP, provides evidence that the proteolytic activity of matriptase, from cells that express no or low levels of HAI-1, may be controlled by secreted serpins. Sequencing analysis revealed the presence of two alpha2-PI gene variations, both in the second half of exon 10: a frameshift mutation and a G to A transition at nucleotide 11337 in codon 407. Observational study of gene-disease association. (HuGE Navigator). Thrombin activatable fibrinolysis inhibitor and alpha(2)-antiplasmin are not markers for recanalization in patients with ischemic stroke treated with recombinant tissue-type plasminogen activator. Fibrinolysis is amplified by converting alpha-antiplasmin from a plasmin inhibitor to a substrate. Hydroxyethyl starch (HES) dilution enhances fibrinolysis by diminishing alpha2-antiplasmin-plasmin interactions. the Arg6Trp polymorphism may play a significant role in governing the long-term deposition/removal of intravascular fibrin. TAFIa, PAI-1 and alpha-antiplasmin: complementary roles in regulating lysis of thrombi and plasma clots. Alpha2-antiplasmin has an important role in acute pulmonary embolism. Multiple Lys residues within alpha 2-antiplasmin contribute, perhaps in a zipper-like fashion, to its binding to the in-tandem, multikringle array that configures the plasmin heavy chain. alpha2-antiplasmin induction inhibits E-cadherin processing mediated by the plasminogen activator/plasmin system, leading to suppression of progression of oral squamous cell carcinoma via upregulation of cell-cell adhesion

Alternate Names

alpha 2-Antiplasmin

Gene Symbol

SERPINF2

Additional Serpin F2/alpha 2-Antiplasmin Products

Product Documents for Serpin F2/alpha 2-Antiplasmin Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Serpin F2/alpha 2-Antiplasmin Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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