PrPSc Antibody (3F4) [Alexa Fluor™ Plus 555]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-81078AFP555

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Product Datasheet / COA / SDS

Recombinant Monoclonal Antibody

View Available Conjugates View Available Formulations

Conjugate

Catalog #

Alexa Fluor 350

NBP2-81078AF350

Alexa Fluor 405

NBP2-81078AF405

Alexa Fluor 488

NBP2-81078AF488

Alexa Fluor 532

NBP2-81078AF532

Alexa Fluor 594

NBP2-81078AF594

Alexa Fluor 647

NBP2-81078AF647

Alexa Fluor 700

NBP2-81078AF700

Alexa Fluor 750

NBP2-81078AF750

Alexa Fluor Plus 488

NBP2-81078AFP488

Alexa Fluor Plus 594

NBP2-81078AFP594

Alexa Fluor Plus 647

NBP2-81078AFP647

Alexa Fluor Plus 680

NBP2-81078AFP680

Allophycocyanin

NBP2-81078APC

Biotin

NBP2-81078B

CoraFluor 1

NBP2-81078CL1

DyLight 350

NBP2-81078UV

DyLight 405

NBP2-81078V

DyLight 488

NBP2-81078G

DyLight 550

NBP2-81078R

DyLight 594

NBP2-81078DL594

DyLight 650

NBP2-81078C

DyLight 680

NBP2-81078FR

DyLight 755

NBP2-81078IR

FITC

NBP2-81078F

HRP

NBP2-81078H

Janelia Fluor 525

NBP2-81078JF525

Janelia Fluor 549

NBP2-81078JF549

Janelia Fluor 646

NBP2-81078JF646

Janelia Fluor 669

NBP2-81078JF669

mFluor Violet 450 SE

NBP2-81078MFV450

mFluor Violet 500 SE

NBP2-81078MFV500

mFluor Violet 610 SE

NBP2-81078MFV610

PE

NBP2-81078PE

PerCP

NBP2-81078PCP

Forumulation

Catalog #

Azide and BSA Free

NBP2-81078

Product Specifications
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Human, Hamster

Applications

Immunohistochemistry, Western Blot, ELISA, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation

Label

Alexa Fluor Plus 555

Antibody Source

Recombinant Monoclonal Mouse IgG₁ kappa Clone # 3F4

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all PrPSc Antibodies »

Product Specifications

Immunogen

Hamster 263K PrPs.

Specificity

The antibody binds specifically to prion, a misfolded protein that has the ability to enter healthy organisms and cause other misfolding of other proteins into their prion form.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG₁ kappa

Applications for PrPSc Antibody (3F4) [Alexa Fluor™ Plus 555]

Application

Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: PrPSc

Prion diseases are transmissible neurodegenerative disorders which affect a range of mammalian species. In humans they can be inherited and sporadic as well as acquired by exposure to human prions. Prions appear to be composed principally of a conformational isomer of host-encoded prion protein and propagate by recruitment of cellular prion protein (1). The function of the cellular prion protein (PrP) is still poorly understood. It has been proposed that one unprecedented role for PrP is against Bax-mediated neuronal apoptosis. It has been shown that PrP potently inhibits Bax-induced cell death in human primary neurons (2). An impaired synaptic inhibition may be involved in the epileptiform activity seen in Creutzfeldt-Jakob and other neurodegenerative diseases and it is believed that loss of function of PrP may contribute to the early synaptic loss and neuronal degeneration seen in these diseases (3).

Alternate Names

Prion Protein Scrapie

Gene Symbol

PRNP

Additional PrPSc Products

Product Documents for PrPSc Antibody (3F4) [Alexa Fluor™ Plus 555]

Product Datasheets

Download Product Datasheets

COA

SDS

Product Specific Notices for PrPSc Antibody (3F4) [Alexa Fluor™ Plus 555]

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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