NF-L Antibody (NEFL/2983R) [Allophycocyanin]
Novus Biologicals, part of Bio-Techne | Catalog # NBP3-08553APC
            Recombinant Monoclonal Antibody
          
        
      Conjugate
              Catalog #
              
            Forumulation
              Catalog #
              
            Key Product Details
Species Reactivity
                  Human, Rat, Porcine, Bovine, Canine, Chicken
                
                                                                                        Applications
                  Immunohistochemistry-Paraffin
                
                                                              Label
            Allophycocyanin (Excitation = 620-650 nm, Emission = 660-670 nm)
          
        Antibody Source
            Recombinant Monoclonal Rabbit IgG Clone # NEFL/2983R
          
        Concentration
            Please see the vial label for concentration. If unlisted please contact technical services.
          
        Product Specifications
Immunogen
                          Recombinant full-length human NF-L protein (Uniprot: P07196)
                      
        Localization
                          Cytoplasmic
                      
        Specificity
                          This monoclonal antibody reacts with a 68kDa protein, identified as light sub-unit of neurofilaments (NF-L). Neurofilaments make up the main structural elements of axons and dendrites and are found in neurons, peripheral nerves, and sympathetic ganglion cells. Neurofilaments consist of three major subunits with molecular weights of 68kDa (NF-L), 160kDa (NF-M) and 200kDa (NF-H). Anti-neurofilament stains a number of neural, neuroendocrine, and endocrine tumors. Neuromas, ganglioneuromas, gangliogliomas, ganglioneuroblastomas, and neuroblastomas stain positively for anti-neurofilament. Neurofilaments are also present in paragangliomas as well as adrenal and extra-adrenal pheochromocytomas. Carcinoids, neuroendocrine carcinomas of the skin, and oat cell carcinomas of the lung also express neurofilament.
                      
        Marker
                          Neuronal Marker
                      
        Clonality
                          Monoclonal
                      
        Host
                          Rabbit
                      
        Isotype
                          IgG
                      
        Applications for NF-L Antibody (NEFL/2983R) [Allophycocyanin]
          Application
        
        
          Recommended Usage
        
      Immunohistochemistry-Paraffin
                                                Optimal dilutions of this antibody should be experimentally determined.
                                                            
                  
        Application Notes
      
      
        Optimal dilution of this antibody should be experimentally determined.
      
    Formulation, Preparation, and Storage
Purification
                          Protein A or G purified 
                      
        Formulation
                          PBS
                      
        Preservative
                          0.05% Sodium Azide
                      
        Concentration
                          Please see the vial label for concentration. If unlisted please contact technical services.
                      
        Shipping
                          The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
                      
        Stability & Storage
                          Store at 4C in the dark.
                      
        Background: NF-L
Antibodies to NF-L may be used to identify NF-L in neurons and to study neuronal processes in tissue sections and/or culture. NF-L antibodies can also be used to study microfilament accumulations seen in many neurological diseases, such as Lou Geri's disease or Alzheimer's disease.
Long Name
            Neurofilament Protein, Light Chain
          
        Alternate Names
            CMT2E, NEFL, NF68, NFL
          
        Gene Symbol
            NEFL
          
        Additional NF-L Products
Product Documents for NF-L Antibody (NEFL/2983R) [Allophycocyanin]
Product Specific Notices for NF-L Antibody (NEFL/2983R) [Allophycocyanin]
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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