Mouse Serpin I1 Alexa Fluor™ Plus 680-conjugated Antibody
R&D Systems, part of Bio-Techne | Catalog # AF5054AFP680
Conjugate
Catalog #
Key Product Details
Species Reactivity
Mouse
Applications
Western Blot
Label
Alexa Fluor Plus 680 (Excitation = 687 nm, Emission = 704 nm)
Antibody Source
Polyclonal Goat IgG
Product Specifications
Specificity
Detects mouse Serpin I1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 50% cross-reactivity with recombinant human (rh) Serpin I1 is observed and less than 5% cross‑reactivity with rhSerpin I2is observed.
Clonality
Polyclonal
Host
Goat
Isotype
IgG
Applications
Application
Recommended Usage
Western Blot
Optimal dilution of this antibody should be experimentally determined.
Background: Serpin I1
Serpin I1 (serine proteinase inhibitor-clade I 1; also protease inhibitor 17 and neuroserpin) is a 52 kDa member of the serpin superfamily of protease inhibitors. It is a component of dense-core secretory granules in neurons of the cerebellum, hippocampus and hypothalamus and following release shows inhibitory activity towards tissue-type plasminogen activator. The mouse Serpin I1 precursor is 410 amino acids (aa) in length. It contains a 16 aa signal sequence plus a reactive center loop that lies between Gly348 and Pro375. Mature mouse Serpin I1 (aa 17‑410) shares 88% and 92% aa identity with human and rat Serpin I1, respectively.
Alternate Names
Neuroserpin, PI12
Gene Symbol
SERPINI1
Additional Serpin I1 Products
Product Specific Notices
This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
For research use only
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