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Key Product Details

Species Reactivity

Mouse, Rat

Applications

Western Blot

Label

Alexa Fluor 594 (Excitation = 590 nm, Emission = 617 nm)

Antibody Source

Monoclonal Rat IgG2A Clone # 726606

Product Specifications

Immunogen

E. coli-derived recombinant mouse TLR7
Asn275-Phe444
Accession # P58681

Specificity

Detects mouse TLR7 in direct ELISAs and mouse and rat TLR7 in Western blots. In direct ELISAs, no cross-reactivity with recombinant human TLR7 or recombinant mouse TLR8 is observed.

Clonality

Monoclonal

Host

Rat

Isotype

IgG2A

Applications for Mouse/Rat TLR7 Alexa Fluor® 594-conjugated Antibody

Application
Recommended Usage

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: TLR7

TLR7 (Toll-like receptor 7) is an approximately 130 kDa type I transmembrane glycoprotein and member of the Toll-like receptor family. Mouse TLR7 cDNA encodes 1050 amino acids (aa) including a 26 aa signal sequence and a 811 aa extracellular domain (ECD) with 28 leucine-rich repeats (LRR). Within the region used as an immunogen (LRR 10-16), mouse TLR7 shares 73% and 88% aa identity with human and rat TLR7, respectively. TLR7 mRNA is detected in brain, placenta, spleen, stomach, small intestine, lung, and in plasmacytoid dendritic cells, B cells and eosinophils. TLR7 participates in the innate immune response to microbial agents by recognizing viral and nonviral single stranded RNA.

Long Name

Toll-like Receptor 7

Alternate Names

toll-like receptor 7

Entrez Gene IDs

51284 (Human); 170743 (Mouse); 317468 (Rat)

Gene Symbol

TLR7

UniProt

Additional TLR7 Products

Product Documents

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Mouse/Rat TLR7 Alexa Fluor® 594-conjugated Antibody


This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

For research use only

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