Mouse/Rat Integrin beta5 Alexa Fluor® 594-conjugated Antibody
R&D Systems, part of Bio-Techne | Catalog # AF8035T
Key Product Details
Species Reactivity
Applications
Label
Antibody Source
Product Specifications
Immunogen
Gly24-Asn719
Accession # NP_001139356
Specificity
Clonality
Host
Isotype
Applications
CyTOF-ready
Flow Cytometry
Immunohistochemistry
Western Blot
Formulation, Preparation, and Storage
Purification
Formulation
Shipping
Stability & Storage
Background: Integrin beta 5
The beta5 integrin is a 95-110 kDa member of the integrin beta chain family, integrin superfamily of molecules. It is expressed by select cell types, including microglia, keratinocytes, fibroblasts, endothelial cells, adhesive monocytes and macrophages, retinal pigment epithelium, immature dendritic cells and colonic epithelium. The Integrin beta5 subunit forms a noncovalent heterodimer with the alphav integrin subunit, and together they bind vitronectin, and the Thy-1 antigen. alphav beta5 is reported to participate in phagocytosis, and act in concert with CD81, CD36 and stabilin-2 on the cell surface. When alphav beta5 binds Thy-1, the heterodimer apparently interfers with cell membrane activation of TGF-beta. Intracellularly, it appears to regulate actin skeleton remodeling via focal adhesion complex formation, and may contribute to cryptic pathways associated with antigen presentation. Mature mouse Integrin beta5 is a 775 amino acid (aa) type I transmembrane glycoprotein that contains a 696 aa extracellular domain (ECD) (aa 24-719) and a 56 aa cytoplasmic region. The ECD contains a 243 aa vWF-A domain (aa 136-378) and a Cys-rich tandem repeat region (aa 465-630). There is one splice variant that shows a 57 aa substitution for aa 760-798. This splice form does not appear to be expressed by the human Integrin beta5 gene. Over aa 24-719, mouse Integrin beta5 shares 91% and 97% aa sequence identity with human and rat Integrin beta5, respectively.
Alternate Names
Gene Symbol
UniProt
Additional Integrin beta 5 Products
Product Specific Notices
This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.
For research use only