Mouse CXCR4 Fluorescein-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB21651F

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FAB21651F-025
FAB21651F-100
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Conjugate
Catalog #
Unconjugated
MAB21651
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Alexa Fluor 350
FAB21651U
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Alexa Fluor 405
FAB21651V
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Alexa Fluor 488
FAB21651G
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Alexa Fluor 532
FAB21651X
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Alexa Fluor 594
FAB21651T
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Alexa Fluor 647
FAB21651R
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Alexa Fluor 700
FAB21651N
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Alexa Fluor 750
FAB21651S
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Alexa Fluor Plus 405
FAB21651AFP405
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Alexa Fluor Plus 488
FAB21651AFP488
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Alexa Fluor Plus 555
FAB21651AFP555
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Alexa Fluor Plus 594
FAB21651AFP594
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Alexa Fluor Plus 647
FAB21651AFP647
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Alexa Fluor Plus 680
FAB21651AFP680
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Allophycocyanin
FAB21651A
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Allophycocyanin/Cy7
FAB21651APCCY7
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Biotin
FAB21651B
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CoraFluor 1
FAB21651CL1
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DyLight 350
FAB21651D
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DyLight 405
FAB21651E
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DyLight 488
FAB21651K
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DyLight 550
FAB21651L
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DyLight 594
FAB21651M
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DyLight 650
FAB21651W
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DyLight 680
FAB21651Y
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DyLight 755
FAB21651Z
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HRP
FAB21651H
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Janelia Fluor 525
FAB21651JF525
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Janelia Fluor 549
FAB21651I
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Janelia Fluor 646
FAB21651J
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Janelia Fluor 669
FAB21651JF669
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mFluor Violet 450 SE
FAB21651MFV450
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mFluor Violet 500 SE
FAB21651MFV500
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mFluor Violet 610 SE
FAB21651MFV610
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PE/Atto594
FAB21651PEATT594
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PE/Cy5.5
FAB21651PECY55
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PE/Cy7
FAB21651PECY7
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Phycoerythrin
FAB21651P
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Key Product Details

Species Reactivity

Validated:

Mouse

Cited:

Mouse

Applications

Validated:

Flow Cytometry

Cited:

Flow Cytometry

Label

FITC (Excitation = 488 nm, Emission = 515-545 nm)

Antibody Source

Monoclonal Rat IgG2B Clone # 247506

View all CXCR4 Antibodies »

Product Specifications

Immunogen

Y3 rat myeloid cell line transfected with mouse CXCR4
Met1-Ser359
Accession # P70658

Specificity

Detects mouse CXCR4 transfectants. Does not stain irrelevant transfectants.

Clonality

Monoclonal

Host

Rat

Isotype

IgG2B

Scientific Data Images for Mouse CXCR4 Fluorescein-conjugated Antibody

Detection of CXCR4 antibody in Mouse Thymocytes antibody by Flow Cytometry.

Detection of CXCR4 in Mouse Thymocytes by Flow Cytometry.

Mouse thymocytes were stained with Rat Anti-Mouse CXCR4 Fluorescein-conjugated Monoclonal Antibody (Catalog # FAB21651F, filled histogram) or isotype control antibody (Catalog # IC013F, open histogram). View our protocol for Staining Membrane-associated Proteins.

Applications for Mouse CXCR4 Fluorescein-conjugated Antibody

Application
Recommended Usage

Flow Cytometry

10 µL/106 cells
Sample: Mouse Thymocytes

Spectra Viewer

Plan Your Experiments

Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.

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Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: CXCR4

CXCR4, also known as CD184, is a G-protein-linked seven transmembrane spanning receptor that binds stromal cell-derived factor-1 (SDF-1). CXCR4 acts as a co-factor for T-cell tropic HIV-1 and -2 viral entry into cells. While primarily a membrane protein, CXCR4 undergoes trafficking and internalization in response to stimulation with phorbol esters and ligand (1). Cytoplasmic and nuclear localization of CXCR4 has been observed in colorectal and renal carcinomas (2,3) and it has been used as the basis of prognosis and metastatic state (3,4,5).

References

  1. Orsini, M.J. et al. (1999) J. Biol. Chem. 274:31076.
  2. Zagzag, D. et al. (2005) Cancer Res. 65:6178.
  3. Speetjens, F.M. et al. (2009) Cancer Microenvironment 2:1.
  4. Wang, L. et al. (2009) Oncology Reports 22:1333.
  5. Amara, S. et al. (2015) Cancer Biomark. 15:869.

Long Name

C-X-C Motif Chemokine Receptor 4

Alternate Names

CD184, D2S201E, FB22, Fusin, HM89, HSY3RR, LAP-3, LAP3, LCR1, LESTR, NPY3R, NPYRL, NPYY3R, WHIMS

Entrez Gene IDs

7852 (Human); 12767 (Mouse); 60628 (Rat); 483900 (Canine); 493676 (Feline)

Gene Symbol

CXCR4

UniProt

P70658

Additional CXCR4 Products

Product Documents for Mouse CXCR4 Fluorescein-conjugated Antibody

Product Datasheets

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Mouse CXCR4 Fluorescein-conjugated Antibody

For research use only

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