Skip to main content

Novus Biologicals products are now on bio-techne.com

Better as one

mGluR8 Antibody - BSA Free, Novus Biologicals

Bio-Techne includes Novus Biologicals | Catalog # NLS922

Catalog #
Availability
Size / Price
Qty
Loading...
NLS922

Key Product Details

Species Reactivity

Human, Mouse, Rat, Bat, Canine, Chicken, Equine, Hamster, Monkey, Primate, Rabbit, Sheep

Applications

Immunocytochemistry, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1.0 mg/ml

Product Summary for mGluR8 Antibody - BSA Free

Immunogen

Synthetic 16 amino acid peptide from N-terminal extracellular domain of human mGluR8.

Epitope

N-Terminus extracellular domain

Predicted Species

Chimpanzee (100%), Fish (94%), Opossum (100%). Backed by our 100% Guarantee.

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Baboon (100%), Galago (100%), Marmoset (100%), Zebrafish (81%).

Specificity

Human mGluR8. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GRM7 (56%).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Product can be stored undiluted at 4C for up to 1 month.

Scientific Data Images for mGluR8 Antibody - BSA Free

Immunohistochemistry-Paraffin: mGluR8 Antibody [NLS922] - Anti-GRM8 / MGLUR8 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 6 ug/ml.
Immunohistochemistry-Paraffin: mGluR8 Antibody [NLS922] - Analysis of anti-GRM8 / MGLUR8 antibody with human brain, cortex at dilution 6 ug/ml.

Applications for mGluR8 Antibody - BSA Free

Application
Recommended Usage

Immunocytochemistry

1:10 - 1:500

Immunohistochemistry-Paraffin

6 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.1% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

Background: mGluR8

Metabotropic Glutamate Receptor GRM8 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. Based on sequence homology, putative signal transduction mechanisms, and pharmacologic properties, GRM8 has been placed in Group III along with GRM4, GRM6, and GRM7. Group II and Group III receptors are linked to inhibition of the cyclic AMP signaling cascade, but differ in their agonist selectivities. Three isoforms of GRM8 are produced by alternative splicing. GRM8 has been reported primarily in the brain. ESTs have been isolated from B-cell/lung/testis, brain, breast, kidney, and testis libraries.

Long Name

Metabotropic Glutamate Receptor 8

Alternate Names

GPRC1H, GRM8

Entrez Gene IDs

2918 (Human)

Gene Symbol

GRM8

Additional mGluR8 Products

Product Documents for mGluR8 Antibody - BSA Free

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for mGluR8 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Loading...