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mGluR8 Antibody (4C1C1) - BSA Free

Catalog # NBP2-61857 | Novus Biologicals a Bio-Techne Brand
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NBP2-61857
NBP2-61857-0.025ml

Key Product Details

Species Reactivity

Human

Applications

ELISA, Flow Cytometry, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 4C1C1

Format

BSA Free

Concentration

1 mg/ml

Product Summary for mGluR8 Antibody (4C1C1) - BSA Free

Immunogen

Purified recombinant fragment of human mGluR8 (AA: extra 440-583) expressed in E. Coli.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Theoretical MW

101.7 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for mGluR8 Antibody (4C1C1) - BSA Free

Western Blot: mGluR8 Antibody (4C1C1) [NBP2-61857] - Analysis using GRM8 mAb against HEK293 (1) and GRM8 (AA: extra 440-583)-hIgGFc transfected HEK293 (2) cell lysate.
Western Blot: mGluR8 Antibody (4C1C1) [NBP2-61857] - Analysis using GRM8 mAb against human GRM8 (AA: extra 440-583) recombinant protein. (Expected MW is 42.6 kDa)
Western Blot: mGluR8 Antibody (4C1C1) [NBP2-61857] - Analysis using GRM8 mouse mAb against C6 (1) cell lysate.

Applications for mGluR8 Antibody (4C1C1) - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Flow Cytometry

1:10-1:1000

Western Blot

1:100-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Format

BSA Free

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: mGluR8

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Long Name

Metabotropic Glutamate Receptor 8

Alternate Names

GPRC1H, GRM8

Gene Symbol

GRM8

Additional mGluR8 Products

Product Documents for mGluR8 Antibody (4C1C1) - BSA Free

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for mGluR8 Antibody (4C1C1) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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