Integrin alpha 2b beta 3 Antibody (2530A) [CoraFluor™ 1]
Novus Biologicals, part of Bio-Techne | Catalog # FAB76161CL1
Recombinant Monoclonal Antibody.
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human
Applications
CyTOF-ready, Flow Cytometry
Label
CoraFluor 1
Antibody Source
Recombinant Monoclonal Rabbit IgG Clone # 2530A
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Product Specifications
Immunogen
Chinese Hamster Ovary cell line, CHO-derived heterodimer of Human Integrin alpha2b (Leu32-Arg993, Accession P08514) and Human Integrin beta3 (Gly27-Asp718, Accession P05106)
Specificity
Detects Human Integrin alpha2b beta3 heterodimer in direct ELISAs. In direct ELISAs, no cross-reactivity with recomabint human (rh) Integrin alpha2b, rhIntegrin alpha5, rhIntegrin alpha5 beta6, rhIntegrin alpha8 beta1, rhIntegrin beta1, rhIntegrin beta2, rhIntegrin beta3, rhIntegrin beta5, rhIntegrin beta7, and recombinant mouse Integrin alpha2b beta3.
Clonality
Monoclonal
Host
Rabbit
Isotype
IgG
Description
CoraFluor(TM) 1 is a high performance terbium-based TR-FRET (Time-Resolved Fluorescence Resonance Energy Transfer) or TRF (Time-Resolved Fluorescence) donor for high throughput assay development. CoraFluor(TM) 1 absorbs UV light at approximately 340 nm, and emits at approximately 490 nm, 545 nm, 585 nm and 620 nm. It is compatible with common acceptor dyes that absorb at the emission wavelengths of CoraFluor(TM) 1. CoraFluor(TM) 1 can be used for the development of robust and scalable TR-FRET binding assays such as target engagement, ternary complex, protein-protein interaction and protein quantification assays.
CoraFluor(TM) 1, amine reactive
CoraFluor(TM) 1, thiol reactive
For more information, please see our CoraFluor(TM) TR-FRET technology flyer.
CoraFluor(TM) 1, amine reactive
CoraFluor(TM) 1, thiol reactive
For more information, please see our CoraFluor(TM) TR-FRET technology flyer.
Applications for Integrin alpha 2b beta 3 Antibody (2530A) [CoraFluor™ 1]
Application
Recommended Usage
CyTOF-ready
Optimal dilutions of this antibody should be experimentally determined.
Flow Cytometry
Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Protein A or G purified
Formulation
PBS
Preservative
No Preservative
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C in the dark. Do not freeze.
Background: Integrin alpha 2b beta 3
Integrin alpha 2b beta 3, also known as GPIIbIIIa, is the most abundant Integrin expressed by megakaryocytes and platelets, both on the surface and within alpha granules. Deficiencies of alpha 2b beta 3 produce Glanzmann thrombasthenia, a potentially serious bleeding disorder. Active cell surface alpha 2b beta 3 adheres to Fibrinogen, mediating platelet/platelet interactions that initiate a cascade of platelet activation and aggregation, extracellular matrix adhesion, formation of thrombi, and clot retraction. It also binds matrix proteins that have an RGD motif, including Fibronectin, Plasminogen, Prothrombin, Thrombospondin, and Vitronectin.
Alternate Names
BDPLT16;BDPLT2;CD41;CD41B;GP2B;GPIIb;GT;GT1;GTA;HPA3;Integrin alpha-IIb;ITGA2B;PPP1R93
Additional Integrin alpha 2b beta 3 Products
Product Documents for Integrin alpha 2b beta 3 Antibody (2530A) [CoraFluor™ 1]
Product Specific Notices for Integrin alpha 2b beta 3 Antibody (2530A) [CoraFluor™ 1]
CoraFluor (TM) is a trademark of Bio-Techne Corp. Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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