Integrin alpha 2b beta 3 Antibody (2530A) [PerCP]
Novus Biologicals, part of Bio-Techne | Catalog # FAB76161C
Recombinant Monoclonal Antibody
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human
Applications
CyTOF-ready, Flow Cytometry
Label
PerCP (Excitation = 490 nm, Emission = 675 nm)
Antibody Source
Recombinant Monoclonal Rabbit IgG Clone # 2530A
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Product Specifications
Immunogen
Chinese Hamster Ovary cell line, CHO-derived heterodimer of Human Integrin alpha2b (Leu32-Arg993, Accession P08514) and Human Integrin beta3 (Gly27-Asp718, Accession P05106)
Specificity
Detects Human Integrin alpha2b beta3 heterodimer in direct ELISAs. In direct ELISAs, no cross-reactivity with recomabint human (rh) Integrin alpha2b, rhIntegrin alpha5, rhIntegrin alpha5 beta6, rhIntegrin alpha8 beta1, rhIntegrin beta1, rhIntegrin beta2, rhIntegrin beta3, rhIntegrin beta5, rhIntegrin beta7, and recombinant mouse Integrin alpha2b beta3.
Clonality
Monoclonal
Host
Rabbit
Isotype
IgG
Applications for Integrin alpha 2b beta 3 Antibody (2530A) [PerCP]
Application
Recommended Usage
CyTOF-ready
Optimal dilutions of this antibody should be experimentally determined.
Flow Cytometry
Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Protein A or G purified from cell culture supernatant
Formulation
PBS
Preservative
0.05% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C in the dark.
Background: Integrin alpha 2b beta 3
Integrin alpha 2b beta 3, also known as GPIIbIIIa, is the most abundant Integrin expressed by megakaryocytes and platelets, both on the surface and within alpha granules. Deficiencies of alpha 2b beta 3 produce Glanzmann thrombasthenia, a potentially serious bleeding disorder. Active cell surface alpha 2b beta 3 adheres to Fibrinogen, mediating platelet/platelet interactions that initiate a cascade of platelet activation and aggregation, extracellular matrix adhesion, formation of thrombi, and clot retraction. It also binds matrix proteins that have an RGD motif, including Fibronectin, Plasminogen, Prothrombin, Thrombospondin, and Vitronectin.
Alternate Names
BDPLT16;BDPLT2;CD41;CD41B;GP2B;GPIIb;GT;GT1;GTA;HPA3;Integrin alpha-IIb;ITGA2B;PPP1R93
Additional Integrin alpha 2b beta 3 Products
Product Documents for Integrin alpha 2b beta 3 Antibody (2530A) [PerCP]
Product Specific Notices for Integrin alpha 2b beta 3 Antibody (2530A) [PerCP]
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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