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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

Product Summary for HVEM/TNFRSF14 Antibody - BSA Free

Immunogen

Antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human TNFRSF14. The immunogen is located within amino acids 20 - 70 of TNFRSF14. Amino Acid Squence: PSCREDEYPVGSECC

Specificity

Multiple isoforms of TNFRSF14 are known to exist.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

23 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for HVEM/TNFRSF14 Antibody - BSA Free

Western Blot: HVEM/TNFRSF14 Antibody [NBP1-76690] - Analysis of 125 ng of TNFRSF14 with TNFRSF14 antibody at 1 ug/mL.
Immunocytochemistry/Immunofluorescence: HVEM/TNFRSF14 Antibody [NBP1-76690] - Mouse Thymus tissue with TNFRSF14 antibody at 10 ug/mL.
Immunohistochemistry-Paraffin: HVEM/TNFRSF14 Antibody [NBP1-76690] - Mouse thymus tissue with TNFRSF14 antibody at 1 ug/ml.

Applications for HVEM/TNFRSF14 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

10 ug/ml

Immunohistochemistry

1 ug/ml

Immunohistochemistry-Paraffin

1 ug/ml

Western Blot

1-2 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: HVEM/TNFRSF14

Tumor necrosis factor receptor (TNFR) superfamily members are defined by cysteine-rich domains in their extracellular regions that bind TNF-related ligands that share a common structural homology in their extracellular domain. TNFRSF14 was initially identified as the Herpesvirus entry mediator and upon binding to the herpes simplex virus (HSV) envelope glycoprotein D or either of its natural ligands LIGHT and lymphotoxin alpha (LT), activates the transcription factors NF-kappaB and AP-1. Activation of this signal transduction pathway in T cells stimulates T cell proliferation and cytokine production, leading to inflammation and enhanced CTL-mediated tumor immunity, suggesting that these proteins may be useful as potential targets for controlling cellular immune responses.

Long Name

Herpesvirus Entry Mediator

Alternate Names

ATAR, CD270, LIGHTR, TNFRSF14

Gene Symbol

TNFRSF14

UniProt

Additional HVEM/TNFRSF14 Products

Product Documents for HVEM/TNFRSF14 Antibody - BSA Free

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for HVEM/TNFRSF14 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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