Human Syntaxin-BP3 Alexa Fluor™ Plus 680-conjugated Antibody
R&D Systems, part of Bio-Techne | Catalog # AF5659AFP680
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human
Applications
Western Blot
Label
Alexa Fluor Plus 680 (Excitation = 687 nm, Emission = 704 nm)
Antibody Source
Polyclonal Goat IgG
Product Specifications
Immunogen
E. coli-derived recombinant human Syntaxin‑BP3
Specificity
Detects human Syntaxin‑BP3 in direct ELISAs and Western blots. In direct ELISAs, less than 5% cross‑reactivity with recombinant human (rh) STXBP1 and rhSTXBP2 is observed.
Clonality
Polyclonal
Host
Goat
Isotype
IgG
Applications
Application
Recommended Usage
Western Blot
Optimal dilution of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Formulation
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
Background: Syntaxin-BP3
Syntaxin‑BP3 (Syntaxin-binding protein 3; also PSP, Munc18-C and -3; and Unc-18C) is a 66‑70 kDa member of the SNARE-interacting Sec1/Munc18 family of proteins. It is expressed in cells that exhibit granule exocytosis, such as neutrophils, mast cells, platelets and endothelial cells. Functionally, it likely participates in the consolidation and secretion of secondary and tertiary granules. Human Syntaxin‑BP3 is 592 amino acids (aa) in length. It contains one SEC1 domain (aa 16‑592). Phosphorylation at Ser129 may stimulate granule release. There are two potential splice variants. One shows a 12 aa substitution for aa 31‑269, while a second shows a one aa Gln insertion after Lys270. Over aa 84‑231, human Syntaxin‑BP3 shares 90% aa identity with mouse Syntaxin‑BP3.
Long Name
Syntaxin-binding Protein 3
Alternate Names
Munc18c, STXBP3, SyntaxinBP3, Unc-18C
Gene Symbol
STXBP3
UniProt
Additional Syntaxin-BP3 Products
Product Specific Notices
This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
For research use only
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