Human SOX14 Antibody

R&D Systems, part of Bio-Techne | Catalog # MAB11693

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MAB11693-100
MAB11693-SP
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2A Clone # 1100814

View all SOX14 Antibodies »

Product Specifications

Immunogen

Synthetic Peptide
Accession # O95416

Specificity

Detects a synthetic peptide specific for human SOX14 around amino acid 190 in Direct ELISA.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Scientific Data Images for Human SOX14 Antibody

Detection of SOX14 in Human Cerebellum.

SOX14 was detected in immersion fixed paraffin-embedded sections of human cerebellum using Mouse Anti-Human SOX14 Monoclonal Antibody (Catalog # MAB11693) at 5 µg/ml for 1 hour at room temperature followed by incubation with the Anti-Mouse IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC001) or the HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using VisUCyte Antigen Retrieval Reagent-Basic (Catalog # VCTS021). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to the nucleus. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Applications for Human SOX14 Antibody

Application
Recommended Usage

Immunohistochemistry

3-25 µg/mL
Sample: Immersion fixed paraffin-embedded sections of human Cerebellum

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Reconstitution

Reconstitute lyophilized material at 0.2 mg/ml in sterile PBS. For liquid material, refer to CoA for concentration.

Reconstitution Buffer Available:
Size / Price
Qty

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: SOX14

SOX14 is a 36 kDa protein that belongs to the SOX (SRY-related HMG-box) family of transcription factors. It plays a crucial role in the development and differentiation of the central nervous system and is critically involved in the regulation of embryogenesis, neural differentiation, and the development of specific neuronal populations. Aberrant expression or mutations of SOX14 have been associated with developmental disorders, including speech and cognitive impairments, as well as various cancers such as medulloblastoma and glioblastoma where it impacts cell proliferation, migration, and survival pathways. SOX14 is also essential for proper neural crest cell development and is implicated in neural tube defects when dysregulated. This makes it an important biomarker for neurological development and related pathologies.

References

  1. Yao L, Zhang J, Xing B, Chen F, Zhang G, Teng Q, Jin J. SOX14 promotes glioma cell proliferation and invasion by suppressing p53 signaling. Oncotarget. 2018 Jun 12;9(45):27646-27657. doi: 10.18632/oncotarget.25542. PMID: 29983854; PMCID: PMC6029639. 
  2. Smit R, Louw S, Stevens J, Kay V. SOX14 is critical for neural crest cell differentiation and neural tube closure in murine embryonic development. J Neurosci Res. 2021 May;99(5):1131-1140. doi: 10.1002/jnr.24759. PMID: 33577345; PMCID: PMC8489940.

Long Name

SRY (sex determining region Y)-box 14

Alternate Names

SOX28

Entrez Gene IDs

8403 (Human); 20669 (Mouse); 300954 (Rat)

Gene Symbol

SOX14

UniProt

O95416 (Mouse)

Additional SOX14 Products

Product Documents for Human SOX14 Antibody

Product Datasheets

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human SOX14 Antibody

For research use only

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