Human PLA2G16 Alexa Fluor™ Plus 680-conjugated Antibody
R&D Systems, part of Bio-Techne | Catalog # AF6190AFP680
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human
Applications
Western Blot
Label
Alexa Fluor Plus 680 (Excitation = 687 nm, Emission = 704 nm)
Antibody Source
Polyclonal Sheep IgG
Product Specifications
Specificity
Detects human PLA2G16 in direct ELISAs and Western blots.
Clonality
Polyclonal
Host
Sheep
Isotype
IgG
Applications
Application
Recommended Usage
Western Blot
Optimal dilution of this antibody should be experimentally determined.
Background: PLA2G16
PLA2G16 (Group 16 phospholipase A2; also HREV107 and AdPLA) is a Ca++‑dependent 17‑18 kDa member of the H‑rev107 family of molecules. It is expressed intracellularly by white adipocytes, induced by insulin, and generates arachadonic acid from phospholipids. The arachadonic acid is converted to PGE2, which binds the EP3 receptor and decreases cAMP levels. This results in decreased hormone‑sensitive lipase activity and increased adiposity. Human PLA216 is 162 amino acids (aa) in length. It is associated with both membranes and cytosol, and may possess a transmembrane segment between aa 134‑154. The enzymatic activity resides in His23 and Cys113. There is one potential isoform that shows a 20 aa substitution for the first four amino acids. Over aa 12 ‑ 132, human PLA2G16 shares 88% aa identity with mouse PLA2G16.
Long Name
Phospholipase A2, Group XVI
Alternate Names
AdPLA, HRASLS3, HREV107
Gene Symbol
PLAAT3
UniProt
Additional PLA2G16 Products
Product Specific Notices
This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
For research use only
Loading...
Loading...
Loading...
Loading...