Human Phospho-EGFR (Y1197) Alexa Fluor™ Plus 594-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB8058AFP594

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FAB8058AFP594-100UG
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Alexa Fluor Plus 594 (Excitation = 590 nm, Emission = 618 nm)

Antibody Source

Monoclonal Rat IgG2B Clone # 869201

View all EGFR Antibodies »

Product Specifications

Specificity

Detects human EGFR when phosphorylated at Y1197 in Western blots.

Clonality

Monoclonal

Host

Rat

Isotype

IgG2B

Applications

Application
Recommended Usage

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Background: EGFR

EGF receptor, also known as ErbB1, is an approximately 160 kDa transmembrane receptor tyrosine kinase that binds multiple EGF family proteins. Ligand binding induces EGFR homodimerization or heterodimerization with ErbB2, 3,or 4 as well as activation of its kinase domain and phosphorylation within the cytoplasmic domain. Phosphorylation of Tyr869 by Src is important for full activation of the receptor. Phosphorylation of Tyr1197 by MAP kinases contributes to EGFR interaction with PIK3C2B. EGFR signaling regulates multiple biological functions including cell proliferation, differentiation, motility, and apoptosis. Three additional alternative splice forms lack the transmembrane and cytoplasmic domains. Within the ECD, human EGFR shares 88% aa sequence identity with mouse and rat EGFR.

Long Name

Epidermal Growth Factor Receptor

Alternate Names

EGF R, ErbB, ErbB1, HER-1

Entrez Gene IDs

1956 (Human); 13649 (Mouse); 24329 (Rat); 102138724 (Cynomolgus Monkey)

Gene Symbol

EGFR

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Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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