Human NSF Alexa Fluor™ Plus 647-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB11766AFP647

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FAB11766AFP647-100UG
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Alexa Fluor Plus 647 (Excitation = 658 nm, Emission = 675 nm)

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 3184A

View all NSF Antibodies »

Product Specifications

Immunogen

Synthetic Peptide

Specificity

Detects a synthetic peptide specific for human NSF around amino acid 520 in direct ELISA

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Applications for Human NSF Alexa Fluor™ Plus 647-conjugated Antibody

Application
Recommended Usage

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: NSF

N-ethylmaleimide-sensitive factor (NSF) is an ATPase of the AAA+ protein family, with a molecular weight of approximately 83 kDa. NSF is a key component of membrane trafficking pathways and plays a central role in the disassembly of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes, thereby facilitating vesicle fusion and neurotransmitter release. It is ubiquitously expressed across cell types and is essential for intracellular trafficking processes such as endocytosis, exocytosis, and autophagosome formation. NSF's functionality extends to maintaining the proper organization and dynamics of intracellular membranes, making it crucial for cellular homeostasis. Dysregulation of NSF activity has been implicated in various pathological conditions, including neurodegenerative disorders, where defects in vesicle fusion processes are linked to cognitive impairment. Additionally, NSF influences the recycling of neurotransmitter receptors and may play a role in synaptic plasticity, highlighting its importance in neuronal function and its potential as a therapeutic target for neurological diseases.

References

  1. Hanson PI, Whiteheart SW. AAA+ proteins: have engine, will work. Nat Rev Mol Cell Biol. 2005 Jul;6(7):519-29. doi: 10.1038/nrm1684. PMID: 16072036.
  2. Yang J, Kong L, Zou L, Liu Y. The role of synaptic protein NSF in the development and progression of neurological diseases. Front Neurosci. 2024 Oct 21;18:1395294. doi: 10.3389/fnins.2024.1395294. PMID: 39498393; PMCID: PMC11532144.
  3. Zhao M, Brunger AT. Recent Advances in Deciphering the Structure and Molecular Mechanism of the AAA+ ATPase N-Ethylmaleimide-Sensitive Factor (NSF). J Mol Biol. 2016 May 8;428(9 Pt B):1912-26. doi: 10.1016/j.jmb.2015.10.026. Epub 2015 Nov 3. PMID: 26546278; PMCID: PMC4854814.

Long Name

N-ethylmaleimide sensitive factor, vesicle fusing ATPase

Alternate Names

DEE96, SEC18, SKD2

Entrez Gene IDs

4905 (Human); 18195 (Mouse); 60355 (Rat)

Gene Symbol

NSF

UniProt

P46459 (Human)

Additional NSF Products

Product Documents

Product Datasheets

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human NSF Alexa Fluor™ Plus 647-conjugated Antibody


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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