Human/Mouse/Rat WWOX Alexa Fluor™ Plus 680-conjugated Antibody

WWOX (WW domain-containing oxidoreductase; also WOX1 and FOR) is a 46 kDa cytoplasmic member of the short-chain dehydrogenases/reductases (or SDR) family of molecules. It is expressed in divergent cell types such as breast epithelium, keratinocytes, osteoblasts, and osteoclasts. WWOX has multiple effects, one of which is that of tumor suppressor. Here, WWOX is likely activated by either TGF-beta binding to surface hyaluronoglucosaminidase 2, or C1q binding to C1qR, which, in both cases, initiates cell apoptosis. Human WWOX is 414 amino acids (aa) in length and contains two WW (TrpTrp) domains (aa 16‑90) with an intervening NLS (aa 50‑55), plus an SDR region that contains a mitochondrial targeting sequence (aa 121‑330). There are multiple phosphorylation sites and multiple splice variants that impact intracellular localization. One shows a deletion of aa 173‑352, a second shows a Lys substitution for aa 36‑414, a third contains a 17 aa substitution for
aa 173‑414, a fourth possesses a 76 aa substitution for aa 138‑414, a fifth shows an 11 aa substitution for aa 353‑414, while a sixth contains a 175 aa substitution for aa 137‑414. Over aa 36‑126, human and mouse WWOX are identical in aa sequence.