Human/Mouse/Rat Thymosin  beta10 Alexa Fluor™ Plus 488-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # AF6429AFP488

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AF6429AFP488-100UG
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot

Label

Alexa Fluor Plus 488 (Excitation = 493 nm, Emission = 518 nm)

Antibody Source

Polyclonal Sheep IgG

View all Thymosin beta 10 Antibodies »

Product Specifications

Immunogen

E. coli-derived recombinant human Thymosin beta10

Specificity

Detects human Thymosin beta10 in direct ELISAs. Detects human, mouse, and rat Thymosin beta10 in Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) Thymosin beta4 and rhThymosin beta16 is observed.

Clonality

Polyclonal

Host

Sheep

Isotype

IgG

Applications

Application
Recommended Usage

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Thymosin beta 10

Thymosin beta 10 (T beta10) is a 6.5 kDa member of the beta-thymosin family of molecules. Members of this family range from 41-44 amino acids (aa) in length, and possess an isoelectric point that lies between pH 5.0-7.0. Multiple cell types produce T beta10, either constitutively, or after stimulation. They include monocytes/macrophages, endothelial cells, thyroid epithelium, spermatids, fetal cerebellar Purkinje cells plus renal tubule epithelium, and multiple tumor types. T beta10 is principally an intracellular molecule. It forms a 1:1 complex with G-actin and blocks F-actin polymerization. This regulates the availablility of actin monomers for filament formation and subsequent cell migration.  It is also known to be noncanonically secreted, acting on endothelium and blocking angiogenesis. Mature human T beta10 is 43 aa in length (aa 2-44) (SwissProt #:P63313). It contains an actin-binding site (aa 18-23), an N-terminal acetylated alanine, four acetylated lysines (#4; 15; 26; 39), and one phosphorylation site at Thr23. Mature T beta10 is identical to mouse T beta10 in aa sequence, and it shares 74% aa sequence identity with its human family member T beta4.

Alternate Names

MIG12, PTMB10, TB10, THYB10, TMSB10

Entrez Gene IDs

9168 (Human); 19240 (Mouse)

Gene Symbol

TMSB10

UniProt

P63313 (Human)

Additional Thymosin beta 10 Products

Product Documents

Product Datasheets

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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