Human/Mouse/Rat CSE1L/CAS Alexa Fluor™ Plus 647-conjugated Antibody
R&D Systems, part of Bio-Techne | Catalog # AF5288AFP647
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human, Mouse, Rat
Applications
Western Blot
Label
Alexa Fluor Plus 647 (Excitation = 658 nm, Emission = 675 nm)
Antibody Source
Polyclonal Goat IgG
Product Specifications
Immunogen
E. coli-derived recombinant human CSE1L
Specificity
Detects endogenous human, mouse, and rat CSE1L in Western blots.
Clonality
Polyclonal
Host
Goat
Isotype
IgG
Applications
Application
Recommended Usage
Western Blot
Optimal dilution of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Formulation
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
Background: CSE1L/CAS
CSE1L (Chromosome segregation 1-like protein; also known as Exportin-2 (XPO2) and Cellular Apoptosis Susceptibility (CAS)) is a 110 kDa member of the XPO2/CSE1 family of proteins. It is expressed in divergent proliferating cell types such as colon and mammary epithelium, fibroblasts, hepatocytes, and spermatogonia. It participates in the export of importin-alpha from the nucleus, and regulates p53-sensitive gene transcription. Human CSE1L is 971 amino acids (aa) in length and contains an N-terminal importin domain (aa 29‑102) and a DNA-association region (aa 372‑385). There are multiple splice variants. There is a six aa substitution for aa 190‑971, separate deletions of aa 133‑341 and 257‑312, an alternate start site at Met235 with a deletion of aa 350‑517, and an alternate start site at Met100 with a 25 aa substitution for aa 674 - 971. Over aa 739‑933, human CSE1L shows 100% aa identity to mouse CSE1L.
Long Name
Chromosome segregation 1-like protein
Alternate Names
CAS, CSE1, XPO2
Gene Symbol
CSE1L
UniProt
Additional CSE1L/CAS Products
Product Specific Notices
This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
For research use only
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