Human Mer Biotinylated Antibody
Catalog # BAF891 | R&D Systems, Inc. a Bio-Techne Brand
Key Product Details
Species Reactivity
Applications
Label
Antibody Source
Product Summary for Human Mer Biotinylated Antibody
Immunogen
Arg26-Ala499
Accession # Q12866
Specificity
Clonality
Host
Isotype
Applications for Human Mer Biotinylated Antibody
Western Blot
Sample: Recombinant Human Mer Fc Chimera (Catalog # 891-MR)
Human Mer Sandwich Immunoassay
Reviewed Applications
Read 2 reviews rated 4.5 using BAF891 in the following applications:
Published Applications
Read 2 publications using BAF891 in the following applications:
Formulation, Preparation and Storage
Purification
Reconstitution
Formulation
Shipping
Stability & Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Mer
Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken c-Eyk) constitute a receptor tyrosine kinase subfamily. The extracellular domains of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. These receptors bind the vitamin K-dependent protein growth-arrest-specific gene 6 (Gas6) which is structurally related to the anticoagulation factor protein S. Binding of Gas6 induces receptor autophosphorylation and downstream signaling pathways that can lead to cell proliferation, migration or the prevention of apoptosis. Recent studies suggest that this family of tyrosine kinase receptors may be involved in hematopoiesis, embryonic development, tumorigenesis and regulation of testicular functions.
References
- Nagata, K. et al. (1996) J. Biol. Chem. 22:30022.
- Crosier, K.E. and P.S Crosier (1997) Pathology 29:131.
Long Name
Alternate Names
Gene Symbol
UniProt
Product Documents for Human Mer Biotinylated Antibody
Product Specific Notices for Human Mer Biotinylated Antibody
For research use only
Citations for Human Mer Biotinylated Antibody (2)
Citations are publications that use Bio-Techne products. Selected citations for Human Mer Biotinylated Antibody include:
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Species: Human
Sample Types: Cell Lysates
Applications: Western BlotZizzo G et al. (2013-04-17), IL-17 stimulates differentiation of human anti-inflammatory macrophages and phagocytosis of apoptotic neutrophils in response to IL-10 and glucocorticoids. J Immunol, 2013-0190(10):5237-46.
PMID: 23596310 -
Species: Human
Sample Types: Cell Lysates
Applications: Western BlotZizzo G et al. (2012-08-31), Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction. J Immunol, 2012-0189(7):3508-20.
PMID: 22942426
There are no citations that match your criteria.
Customer Reviews for Human Mer Biotinylated Antibody (2)
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Application: ELISASample Tested: A549 human lung carcinoma cell lineSpecies: HumanVerified Customer | Posted 04/26/2017
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Application: Immunocytochemistry/ImmunofluorescenceSample Tested: HUMAN MACROPHAGESSpecies: HumanVerified Customer | Posted 07/03/2016
There are no reviews that match your criteria.
Reconstitution Calculator
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.