Human MASTL Alexa Fluor™ Plus 488-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # AF10022AFP488

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AF10022AFP488-100UG
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Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry

Label

Alexa Fluor Plus 488 (Excitation = 493 nm, Emission = 518 nm)

Antibody Source

Polyclonal Goat IgG

View all MASTL Antibodies »

Product Specifications

Specificity

Detects human MASTL in direct ELISA.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Applications for Human MASTL Alexa Fluor™ Plus 488-conjugated Antibody

Application
Recommended Usage

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Background: MASTL

MAST-L is a ubiquitous microtubule associated serine/threonine kinase which plays a key role in mitosis. During entry into mitosis, CDK1 and MASTL kinase repress the activity of mitotic protein phosphatases PP1 and PP2A. Mitotic exit requires partial dephosphorylation of MASTL by PP1, followed by dephosphorylation of PP2A. PP1 is partially reactivated by decreases in CDK1 activity. PP1 then reactivates PP1A. Mutations of MASTL have been associated with autosomal dominant thrombocytopenia, a decrease in the number of platelets circulating in blood. MASTL kinase is frequently upregulated in several cancers, and is correlated with cancer progression, poor patient survival and tumor recurrence. Ectopic expression of MASTL in tumor cells has been shown to promote cell proliferation, and MASTL has been identified as a target for therapeutic intervention.

Long Name

MASTL

Alternate Names

Greatwall, THC2

Entrez Gene IDs

84930 (Human); 67121 (Mouse)

Gene Symbol

MASTL

UniProt

Q96GX5

Additional MASTL Products

Product Documents

Product Datasheets

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human MASTL Alexa Fluor™ Plus 488-conjugated Antibody


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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