Human Integrin beta8 APC-conjugated Antibody
R&D Systems, part of Bio-Techne | Catalog # FAB4775A
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human
Applications
Flow Cytometry
Label
Allophycocyanin (Excitation = 620-650 nm, Emission = 660-670 nm)
Antibody Source
Monoclonal Mouse IgG2B Clone # 416922
Product Specifications
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Integrin beta8
Glu43-Arg684 (predicted)
Accession # P26012
Glu43-Arg684 (predicted)
Accession # P26012
Specificity
Detects human Integrin beta8 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human Integrins beta1, beta2, beta3, beta4, beta5, beta6 beta7, or recombinant mouse Integrin beta8 is observed.
Clonality
Monoclonal
Host
Mouse
Isotype
IgG2B
Scientific Data Images for Human Integrin beta8 APC-conjugated Antibody
Detection of Integrin beta8 in WM-115 Human Cell Line by Flow Cytometry.
WM-115 human melanoma cell line was stained with Mouse Anti-Human Integrin beta8 APC-conjugated Monoclonal Antibody (Catalog # FAB4775A, filled histogram) or isotype control antibody (Catalog # IC0041A, open histogram). View our protocol for Staining Membrane-associated Proteins.Applications for Human Integrin beta8 APC-conjugated Antibody
Application
Recommended Usage
Flow Cytometry
10 µL/106 cells
Sample: WM-115 human melanoma cell line
Sample: WM-115 human melanoma cell line
Spectra Viewer
Plan Your Experiments
Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.
Spectra Viewer
Formulation, Preparation, and Storage
Purification
Protein A or G purified from hybridoma culture supernatant
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: Integrin beta 8
Integrin beta 8 (Integrin beta8) is a 90 kDa type I transmembrane glycoprotein of the Integrin family of adhesion molecules. It associates with Integrin alphaV to form a receptor for vitronectin, fibrin, and the latency associated peptide (LAP). Binding to LAP promotes the proteolytic release of active TGF-beta from LAP. Integrin alphaV beta8 is required for vascular morphogenesis in the embryonic brain and yolk sac. Within the extracellular domain, human Integrin beta8 shares 87% aa sequence identity with mouse and rat Integrin beta8.
Alternate Names
ITGB8
Gene Symbol
ITGB8
UniProt
Additional Integrin beta 8 Products
Product Documents for Human Integrin beta8 APC-conjugated Antibody
Product Specific Notices for Human Integrin beta8 APC-conjugated Antibody
For research use only
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