Human Integrin beta6 Antibody
R&D Systems, part of Bio-Techne | Catalog # MAB41551
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human
Applications
Western Blot
Label
Unconjugated
Antibody Source
Monoclonal Mouse IgG2B Clone # 437216
Product Specifications
Immunogen
Chinese hamster ovary cell line CHO-derived recombinant human Integrin beta6
Gly22-Asn707
Accession # P18564
Gly22-Asn707
Accession # P18564
Specificity
Detects human Integrin beta6 in direct ELISAs and Western blots. In Western blots (under reducing conditions), 40% cross‑reactivity with recombinant human (rh) Integrin beta2 is observed and no cross-reactivity with rhIntegrin beta1, 3, 5, 7, or 8 is observed.
Clonality
Monoclonal
Host
Mouse
Isotype
IgG2B
Applications for Human Integrin beta6 Antibody
Application
Recommended Usage
Western Blot
1 µg/mL
Sample: Recombinant Human Integrin beta6
Sample: Recombinant Human Integrin beta6
Formulation, Preparation, and Storage
Purification
Protein A or G purified from hybridoma culture supernatant
Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Integrin beta 6
Integrin beta6 (ITG beta6) is a 95 kDa member of the Integrin beta family. It forms noncovalent heterodimers with Integrin alphaV and appears on epithelia following injury or inflammation. It activates TGF-beta and assists keratinocyte migration. Human Integrin beta6 is a type I transmembrane glycoprotein that is 767 aa in length. It contains a 688 aa extracellular domain (ECD) (aa 22‑709) that incorporates a 241 aa VWF-A domain. Over aa 22‑707, human integrin beta6 ECD shares 90% and 93% aa sequence identity with mouse and porcine integrin beta6 ECD, respectively.
Alternate Names
ITGB6
Gene Symbol
ITGB6
UniProt
Additional Integrin beta 6 Products
Product Documents for Human Integrin beta6 Antibody
Product Specific Notices for Human Integrin beta6 Antibody
For research use only
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