Human IGFBP‑6 Antibody
Catalog # MAB8761 | R&D Systems, Inc. a Bio-Techne Brand
Key Product Details
Species Reactivity
Applications
Label
Antibody Source
Product Summary for Human IGFBP‑6 Antibody
Immunogen
Ala25-Gly240
Accession # P24592
Specificity
Clonality
Host
Isotype
Applications for Human IGFBP‑6 Antibody
Western Blot
Sample: Recombinant Human IGFBP‑6 (Catalog # 876-B6)
Human IGFBP-6 Sandwich Immunoassay
Published Applications
Read 4 publications using MAB8761 in the following applications:
Formulation, Preparation and Storage
Purification
Reconstitution
Formulation
Shipping
Stability & Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: IGFBP-6
The superfamily of insulin-like growth factor (IGF) binding proteins include the six high-affinity IGF binding proteins (IGFBP) and at least four additional low-affinity binding proteins referred to as IGFBP related proteins (IGFBP-rP). All IGFBP superfamily members are cysteine-rich proteins with conserved cysteine residues, which are clustered in the amino- and carboxy-terminal thirds of the molecule. IGFBPs modulate the biological activities of IGF proteins. Some IGFBPs may also have intrinsic bioactivity that is independent of their ability to bind IGF proteins. Post-transitional modifications of IGFBP, including glycosylation, phosphorylation and proteolysis, have been shown to modify the affinities of the binding proteins to IGF. Human IGFBP-6 cDNA encodes a 240 amino acid (aa) residue precursor protein with a putative 24 aa residue signal peptide that is processed to generate the 216 aa residue mature protein that is O-glycosylated. IGFBP-6 is expressed in ovarian cells, prostatic cells, and fibroblasts. IGFBP-6 is found predominantly in CSF and serum. IGFBP-6 binds preferentially to IGF-II, exhibiting a 2-fold higher affinity for IGF-II than for IGF-I.
Product Documents for Human IGFBP‑6 Antibody
Product Specific Notices for Human IGFBP‑6 Antibody
For research use only
Citations for Human IGFBP‑6 Antibody (4)
Citations are publications that use Bio-Techne products. Selected citations for Human IGFBP‑6 Antibody include:
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Species: Human
Sample Types: Cell Lysates
Applications: Western BlotM Conese et al. (2020-06-22), Insulin-Like Growth Factor Binding Protein 6 Is Secreted in Extracellular Vesicles upon Hyperthermia and Oxidative Stress in Dendritic Cells But Not in Monocytes Int J Mol Sci, 2020-021(12).
PMID: 32580339 -
Species: Human
Sample Types: Whole Tissue,Cell Lysates
Applications: Western Blot,IHC-PQ Chen et al. (2016-10-18), IGFBP6 is a novel nasopharyngeal carcinoma prognostic biomarker Oncotarget, 2016-17(42):68140-68150.
PMID: 27623076 -
Species: Human
Sample Types: Urine
Applications: Antibody Array DevelopmentHu H et al. (2009-06-27), Noninvasive detection of acute and chronic injuries in human renal transplant by elevation of multiple cytokines/chemokines in urine. Transplantation, 2009-087(12):1814-20.
PMID: 19543058 -
Species: Human
Sample Types: Recombinant Protein
Applications: Western BlotNakamura M et al. (2005-08-05), Matrix metalloproteinase-7 degrades all insulin-like growth factor binding proteins and facilitates insulin-like growth factor bioavailability. Biochem. Biophys. Res. Commun., 2005-0333(3):1011-6.
PMID: 15964556
There are no citations that match your criteria.
Reconstitution Calculator
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