Human HNF-4 alpha/NR2A1 MAb (Cl H1415) (Protein A Purified)

Name: Human HNF-4 alpha/NR2A1 MAb (Cl H1415) (Protein A Purified)
Brand: R&D Systems
SKU: PP-H1415-0C
Price: 453 USD

R&D Systems, Inc. a Bio-Techne Brand

Catalog # PP-H1415-0C

Citations (3)

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Species Reactivity:	Human
Applications:	Chromatin Immunoprecipitation, ELISA, Gel Shift, Immunohistochemistry, Immunoprecipitation, Western Blot
Label:	Unconjugated

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Applications for Human HNF-4 alpha/NR2A1 MAb (Cl H1415) (Protein A Purified)

	Recommended Concentration	Sample
Western Blot		Please refer to the PDF datasheet for specifications.
Immunohistochemistry		Please refer to the PDF datasheet for specifications.
Immunoprecipitation		Please refer to the PDF datasheet for specifications.
Chromatin Immunoprecipitation (ChIP)		Please refer to the PDF datasheet for specifications.
Direct ELISA		Please refer to the PDF datasheet for specifications.
Gel Supershift Assay		Please refer to the PDF datasheet for specifications.

Please Note: Optimal dilutions should be determined by each laboratory for each application.

Formulation, Preparation and Storage

Stability & Storage

Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

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Background: HNF-4 alpha/NR2A1

Hepatocyte Nuclear Factor 4 alpha (HNF4 alpha; NR2A1) is a member of the orphan nuclear receptor family. HNF4 alpha is expressed in the liver, kidney, intestine and pancreas. Mutation of HNF4 alpha in humans has been associated with maturity-onset diabetes of the young type 1 (MODY1). HNF4 binds to DNA as an exclusive homodimer. The HNF4 alpha gene is alternatively spliced and may generate up to nine different isoforms, HNF4 alpha 1 through HNF4 alpha 9. The expression of HNF-4 gamma (NR2A2) is observed in the pancreas, kidney, small intestine, and testes with no expression detected in the liver. The level of HNF-4 gamma is less 10% than that of HNF-4 alpha.

Item	Value
Long Name	Hepatocyte Nuclear Factor-4, alpha
Entrez Gene IDs	3172 (Human)
Alternate Names	FLJ39654, HNF-4 alpha, HNF-4-alpha, HNF4 alpha, HNF4A, HNF4HNF4a8, HNF4a7, HNF4alpha10/11/12, MODY, MODY1, NR2A1, NR2A1HNF4a9, NR2A21, Nuclear receptor subfamily 2 group A member 1, TCF, TCF-14, TCF14, TCF14HNF4alpha, Transcription factor 14, Transcription factor HNF-4, hepatic nuclear factor 4 alpha, hepatocyte nuclear factor 4, alpha, hepatocyte nuclear factor 4-alpha, transcription factor-14

Citations for Human HNF-4 alpha/NR2A1 MAb (Cl H1415) (Protein A Purified) (3)

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Citations are publications that use Bio-Techne products. Selected citations for Human HNF-4 alpha/NR2A1 MAb (Cl H1415) (Protein A Purified) include:

Species: Mouse
Sample Types: Whole Tissue
Applications: IHC

V Veeriah et al. (2022), Long-term oral administration of an HNF4alpha agonist prevents weight gain and hepatic steatosis by promoting increased mitochondrial mass and function Cell Death Disease, 2022;13(1):89.
PMID: 35087037
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

S Lee et al. (2022), Mechanism of paracrine communications between hepatic progenitor cells and endothelial cells Cellular Signalling, 100(0):110458.
PMID: 36055565
Species: Human
Sample Types: Whole Cells
Applications: ICC

PA Subramani et al. (2020), Plasmodium vivax liver stage assay platforms using Indian clinical isolates Malar. J., 19(1):214.
PMID: 32571333

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Human HNF-4 alpha/NR2A1 MAb (Cl H1415) (Protein A Purified)

R&D Systems, Inc. a Bio-Techne Brand

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Applications for Human HNF-4 alpha/NR2A1 MAb (Cl H1415) (Protein A Purified)

Formulation, Preparation and Storage

Reconstitution Calculator

Background: HNF-4 alpha/NR2A1

Citations for Human HNF-4 alpha/NR2A1 MAb (Cl H1415) (Protein A Purified) (3)

Product Documents for Human HNF-4 alpha/NR2A1 MAb (Cl H1415) (Protein A Purified)

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