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Human HNF-4 alpha/NR2A1 MAb (Cl H1415) (Protein A Purified)

Bio-Techne includes R&D Systems | Catalog # PP-H1415-0C

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PP-H1415-0C

Key Product Details

Species Reactivity

Validated:

Human

Cited:

Mouse

Applications

Chromatin Immunoprecipitation (ChIP), Direct ELISA, Gel Supershift Assay, Immunohistochemistry, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2A Clone # H1415

Product Summary for Human HNF-4 alpha/NR2A1 MAb (Cl H1415) (Protein A Purified)

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Applications for Human HNF-4 alpha/NR2A1 MAb (Cl H1415) (Protein A Purified)

Application
Recommended Usage

Chromatin Immunoprecipitation (ChIP)

Direct ELISA

Gel Supershift Assay

Immunohistochemistry

Immunoprecipitation

Western Blot

Please Note: Optimal dilutions of this antibody should be experimentally determined.

Published Applications

Read 3 publications using PP-H1415-0C in the following applications:

Formulation, Preparation, and Storage

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: HNF-4 alpha/NR2A1

Hepatocyte Nuclear Factor 4 alpha (HNF4 alpha; NR2A1) is a member of the orphan nuclear receptor family. HNF4 alpha is expressed in the liver, kidney, intestine and pancreas. Mutation of HNF4 alpha in humans has been associated with maturity-onset diabetes of the young type 1 (MODY1). HNF4 binds to DNA as an exclusive homodimer. The HNF4 alpha gene is alternatively spliced and may generate up to nine different isoforms, HNF4 alpha 1 through HNF4 alpha 9. The expression of HNF-4 gamma (NR2A2) is observed in the pancreas, kidney, small intestine, and testes with no expression detected in the liver. The level of HNF-4 gamma is less 10% than that of HNF-4 alpha.

Long Name

Hepatocyte Nuclear Factor-4, alpha

Alternate Names

HNF4 alpha, HNF4A, MODY1, NR2A1, TCF14

Entrez Gene IDs

3172 (Human)

Gene Symbol

HNF4A

Additional HNF-4 alpha/NR2A1 Products

Product Documents for Human HNF-4 alpha/NR2A1 MAb (Cl H1415) (Protein A Purified)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human HNF-4 alpha/NR2A1 MAb (Cl H1415) (Protein A Purified)

For research use only

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