Human Hematopoietic Prostaglandin D Synthase/HPGDS Alexa Fluor™ Plus 488-conjugated Antibody
R&D Systems, part of Bio-Techne | Catalog # AF6487AFP488
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human
Applications
Western Blot
Label
Alexa Fluor Plus 488 (Excitation = 493 nm, Emission = 518 nm)
Antibody Source
Polyclonal Sheep IgG
Product Specifications
Immunogen
E. coli-derived recombinant human Hematopoietic Prostaglandin D Synthase/HPGDS
Specificity
Detects human Hematopoietic Prostaglandin D Synthase/HPGDS in direct ELISAs and Western blots.
Clonality
Polyclonal
Host
Sheep
Isotype
IgG
Applications
Application
Recommended Usage
Western Blot
Optimal dilution of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Formulation
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
Background: Hematopoietic Prostaglandin D Synthase/HPGDS
Prostaglandin D Synthase (PGDS) catalyzes the conversion of prostaglandin (PG) H2 to PGD2, which is a major prostanoid produced in a variety of tissues. Two types of PGDS have been isolated; the glutathione-dependent hematopoietic PGDS (HPGDS) and the glutathione-independent lipocalin‑type PGDS (1). HPGDS is a cytosolic enzyme that is expressed in mast cells and antigen presenting cells (2, 3). It is the only mammalian member of the class Sigma glutathione S‑transferase, showing a broad specificity towards standard transferase substrates (4). The PGD2 produced by HPGDS is involved in many physiological processes such as maintaining body temperature, promotion of sleep, inhibition of platelet aggregation and bronchoconstriction (5). It also functions in immune response and acts as a mediator in allergy and inflammation (6). HPGDS‑specific inhibitors may be therapeutically useful anti‑allergic and anti‑inflammatory drugs.
References
- Urade, Y. and Eguchi, N. (2002) Prostaglandins Other Lipid Mediat. 68:375.
- Urade, Y. et al. (1990) J. Biol. Chem. 265:371.
- Urade, Y. et al. (1989) J. Immunol. 143:2982.
- Jowsey, I. R. et al. (2001) Biochem. J. 359:507.
- Kanaoka, Y. and Urade, Y. (2003) Prostaglandins Leukot. Essent. Fatty Acids 69:163.
- Oguma, T. et al. (2008) Allergol. Int. 57:307.
Alternate Names
GSTS, PGDS, PTGDS2
Gene Symbol
HPGDS
UniProt
Additional Hematopoietic Prostaglandin D Synthase/HPGDS Products
- All Products for Hematopoietic Prostaglandin D Synthase/HPGDS
- Hematopoietic Prostaglandin D Synthase/HPGDS ELISA Kits
- Hematopoietic Prostaglandin D Synthase/HPGDS Lysates
- Hematopoietic Prostaglandin D Synthase/HPGDS Primary Antibodies
- Hematopoietic Prostaglandin D Synthase/HPGDS Proteins and Enzymes
Product Specific Notices
This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
For research use only
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