PC-3 human prostate cancer cell line was stained with Mouse Anti-Human Claudin-3 APC-conjugated Monoclonal Antibody (Catalog # FAB4620A, filled histogram) or isotype control antibody (Catalog # IC003A, open histogram). View our protocol for Staining Membrane-associated Proteins.

Applications for Human Claudin-3 APC-conjugated Antibody

Application

Recommended Usage

Flow Cytometry

10 µL/10⁶ cells
Sample: PC‑3 human prostate cancer cell line

Reviewed Applications

Read 1 review rated 5 using FAB4620A in the following applications:

Flow Cytometry (1 Review)

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze.

12 months from date of receipt, 2 to 8 °C as supplied.

Background: Claudin-3

Claudin-3 is a 23 kDa multipass membrane protein in the claudin family of epithelial tight junction proteins. Claudin-3 is upregulated by EGF and in inflammation and a variety of epithelial cancers. Its expression is lost in the blood brain barrier during pathological disruptions of that structure. Claudin-3 binding to the Clostridium perfringes exotoxin induces epithelial cell lysis. Human Claudin-3 shares 91% amino acid sequence identity with mouse and rat Claudin-3.

Alternate Names

Claudin3, CLDN3, CPE-R 2, CPETR2, HRVP1

Entrez Gene IDs

1365 (Human); 12739 (Mouse); 65130 (Rat)

Gene Symbol

CLDN3

UniProt

O15551

Additional Claudin-3 Products

Product Documents for Human Claudin-3 APC-conjugated Antibody

Product Datasheets

Download Product Datasheets

COA

SDS

Download SDS

Product Specific Notices for Human Claudin-3 APC-conjugated Antibody

For research use only

Citations
Reviews

Spectra Viewer
Flow Cytometry

Human Claudin-3 APC-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB4620A

Key Product Details

Species Reactivity

Applications

Label

Antibody Source

View all Claudin-3 Antibodies »

Product Specifications

Immunogen

Specificity

Clonality

Host

Isotype

Scientific Data Images for Human Claudin-3 APC-conjugated Antibody

Detection of Claudin‑3 in PC‑3 Human Cell Line by Flow Cytometry.