Human CEACAM-3/CD66d Alexa Fluor™ Plus 680-conjugated Antibody
R&D Systems, part of Bio-Techne | Catalog # FAB4166AFP680
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human
Applications
Western Blot
Label
Alexa Fluor Plus 680 (Excitation = 687 nm, Emission = 704 nm)
Antibody Source
Monoclonal Mouse IgG2A Clone # 417009
Product Specifications
Immunogen
Mouse myeloma cell line NS0-derived recombinant human CEACAM‑3/CD66d isoform 1
Specificity
Detects human CEACAM‑3/CD66d in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human CEACAM-1, -4, -5, or -6 is observed.
Clonality
Monoclonal
Host
Mouse
Isotype
IgG2A
Applications
Application
Recommended Usage
Western Blot
Optimal dilution of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Formulation
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
Background: CEACAM-3/CD66d
Carcinoembryonic Antigen-related Cell Adhesion Molecule 3, (CEACAM-3) also known as CD66d and CGM1, is a 35 kDa transmembrane glycoprotein in the CEACAM family of the immunoglobulin superfamily. The extracellular region consists of one Ig-like V-type domain, and the cytoplasmic tail contains one ITAM. CEACAM-3 is upregulated on activated neutrophils and mediates their adhesion to vascular endothelial cells. CEACAM-3 binds the Opa opacity proteins on some Gram negative bacteria, leading to bacterial uptake and neutrophil death. Alternate splicing generates an isoform with a substituted cytoplasmic tail and a potentially secreted isoform that contains a highly charged and Ser/Thr-rich sequence in place of the transmembrane and cytoplasmic regions. Orthologs of human CEACAM-3 have not been identified in other species.
Long Name
Carcinoembryonic Antigen-related Cell Adhesion Molecule 3
Alternate Names
CD66d, CGM1
Gene Symbol
CEACAM3
UniProt
Additional CEACAM-3/CD66d Products
Product Specific Notices
This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
For research use only
Loading...
Loading...
Loading...
Loading...