Human beta-1,3-N-acetylglucosaminyl-transferase 2/B3GNT2 Alexa Fluor™ Plus 488-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB3960AFP488

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FAB3960AFP488-100UG
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Alexa Fluor Plus 488 (Excitation = 493 nm, Emission = 518 nm)

Antibody Source

Monoclonal Mouse IgG2B Clone # 485327

View all Beta-1,3-N-Acetylglucosaminyltransferase 2/B3GNT2 Antibodies »

Product Specifications

Immunogen

Mouse myeloma cell line NS0-derived recombinant human beta-1,3-N-acetylglucosaminyltransferase 2/B3GNT2

Specificity

Detects human beta-1,3-N-acetylglucosaminyltransferase 2/B3GNT2 in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human B4GALT1 is observed

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Applications

Application
Recommended Usage

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Beta-1,3-N-Acetylglucosaminyltransferase 2/B3GNT2

beta1,3-Linked GlcNAc residues are present in the backbone of various biologically important glycans which are involved in many essential biological functions such as keratan sulfate synthesis in corneal tissue (1). The addition of such residues are catalyzed by a family of beta1,3‑N‑acetylglucosaminyltransferases, that includes at least eight members (1‑5).  All of them are type II Golgi resident transmembrane proteins and have high homology to the beta1,3-galactosyltransferase family. beta1,3‑N‑acetylglucosaminyltransferases 2 or beta3GNT2 prefers the substrate lacto-N-neotetraose and is involved in the biosynthesis of poly-N-acetyllactosamine chains (6).

References

  1. Seko, A. and Yamashita, K. (2005) Glycobiology 15:943.
  2. Kataoka, K. and Huh, N.-H. (2002) Biochem. Biophys. Res. Commun. 294:843.
  3. Iwai,T. et al. (2002) J. Biol. Chem. 277:12802.
  4. Togayachi, A. et al. (2001) J. Biol. Chem. 276:22032.
  5. Sasaki, K. et al. (1997) Proc. Natl. Acad. Sci. USA 94:14294.
  6. Shiraishi, N. et al. (2001) J. Biol. Chem. 276:3498.

Long Name

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyl-transferase 1

Alternate Names

B3Galt6, Beta3gnt1

Entrez Gene IDs

10678 (Human); 53625 (Mouse)

Gene Symbol

B3GNT2

UniProt

Q9NY97

Additional Beta-1,3-N-Acetylglucosaminyltransferase 2/B3GNT2 Products

Product Documents

Product Datasheets

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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