Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 60402

View all Activin RIIB Antibodies »

Product Specifications

Immunogen

Mouse myeloma cell line NS0-derived recombinant human Activin RIIB
Ser19-Thr134
Accession # Q13705

Specificity

Detects human Activin RIIB in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 5% cross-reactivity with recombinant human Activin RIIA is observed.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for Human Activin RIIB Antibody

Application
Recommended Usage

Western Blot

1 µg/mL
Sample: Recombinant Human Activin RIIB Fc Chimera (Catalog # 339-RB)

Reviewed Applications

Read 1 review rated 5 using MAB3393 in the following applications:

Formulation, Preparation, and Storage

Purification

Protein A or G purified from ascites

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Reconstitution Buffer Available:
Size / Price
Qty

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Activin RIIB

Members of the TGF-beta superfamily exert their biological effects by binding to heteromeric complexes of a type I and a type II serine-threonine kinase receptor, both of which are essential for signal transduction. Activin receptor type IIB is a type II receptor that mediates multiple signals for transforming growth factor‑beta (TGF‑beta) family members, including Activin, Nodal, Bmp7, Gdf1, Gdf3, Myostatin (Gdf8), and Gdf11. Through alternative mRNA splicing, multiple ActR-IIB isoforms can also be generated. Human, mouse and rat activin RIIB share greater than 98% amino acid sequence homology.

Long Name

Activin Receptor IIB

Alternate Names

ActivinRIIB, ACVR2B

Entrez Gene IDs

93 (Human); 11481 (Mouse)

Gene Symbol

ACVR2B

UniProt

Q13705

Additional Activin RIIB Products

Product Documents for Human Activin RIIB Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Download SDS

Product Specific Notices for Human Activin RIIB Antibody

For research use only

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