HGFR/c-MET [p Tyr1349] Antibody (S05-3D6)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-14874

Recombinant Monoclonal Antibody
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NBP3-14874-25ul
NBP3-14874-100ul
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S05-3D6 expressed in HEK293

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all HGFR/c-MET Antibodies »

Product Specifications

Immunogen

A synthetic phosphopeptide corresponding to residues surrounding Tyr1349 of human HGFR/c-MET (Uniprot#: P08581)

Modification

p Tyr 1349

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for HGFR/c-MET [p Tyr1349] Antibody (S05-3D6)

Western Blot: HGFR/c-MET [p Tyr1349] Antibody (S05-3D6) [NBP3-14874] - Western blot detection of HGFR/c-MET [p Tyr1349] in Hela, A549 cell lysates using HGFR/c-MET [p Tyr1349] Rabbit mAb (1:1000 diluted). Predicted band size: 156kDa. Observed band size: 170-140kDa.

Applications for HGFR/c-MET [p Tyr1349] Antibody (S05-3D6)

Application
Recommended Usage

Western Blot

1/1000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: HGFR/c-MET

Met is a receptor protein-tyrosine kinase (RPTK) for hepatocyte growth factor (HGF), which is a multifunctional cytokine controlling cell growth, morphogenesis, and motility. Met overexpression has been identified in a variety of human cancers (1). Met kinase domain possesses unique features that distinguish met from other members of the src family of protein tyrosine kinases. These results also demonstrate that the product of the activated met gene is a fusion protein and that the amino terminal end of this fusion protein exhibits homology to laminin B1 (2). Data suggest that RanBP9, functioning as an adaptor protein for the Met tyrosine kinase domain, can augment the HGF-Met signaling pathway and that RanBP9 overexpression may cause constitutive activation of the Ras signaling pathway (1). Hereditary papillary renal carcinoma (HPRC) is a recently recognized form of inherited kidney cancer Results suggest that missense mutations located in the MET proto-oncogene lead to constitutive activation of the Met protein and papillary renal carcinomas (3)

Long Name

Hepatocyte Growth Factor Receptor

Alternate Names

c-MET, cMET, HGF R, MET

Gene Symbol

MET

Additional HGFR/c-MET Products

Product Documents for HGFR/c-MET [p Tyr1349] Antibody (S05-3D6)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for HGFR/c-MET [p Tyr1349] Antibody (S05-3D6)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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