ErbB2/Her2 Antibody [ADC] - (Trastuzumab Deruxtecan, Research Grade)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-44527

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NBP3-44527
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Flow Cytometry, Functional

Label

ADC

Antibody Source

Monoclonal Human IgG1

Concentration

LYOPH mg/ml

View all ErbB2/Her2 Antibodies »

Product Specifications

Immunogen

ErbB2/Her2 (Uniprot: P04626)

Clonality

Monoclonal

Host

Human

Isotype

IgG1

Theoretical MW

153.75 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Description

This product is an Antibody-Drug Conjugate (ADC) for Research Use Only (RUO).

Trastuzumab deruxtecan is a HER2-targeting ADC structurally composed of a humanized anti-HER2 antibody, enzymatically cleavable peptide-linker, and a novel topoisomerase I inhibitor (DXd), which is cell-membrane permeable and more potent than SN-38 the active metabolite of irinotecan.

This product is shipped at ambient temperature. Upon receipt, store immediately at -20C or lower for 12 months in a lyophilized state. - 80C for 3 months after reconstitution. Avoid repeated freeze-thaw cycles.

Scientific Data Images for ErbB2/Her2 Antibody [ADC] - (Trastuzumab Deruxtecan, Research Grade)

Hu ErbB2/Her2 mAb [ADC] - (Trastuzumab Deruxtecan) [NBP3-44527] -

ELISA: Hu ErbB2/Her2 mAb [ADC] - (Trastuzumab Deruxtecan) [NBP3-44527] -

Immobilized human HER2(23 652) His at 2 ug/mL can bind ErbB2/Her2 (Trastuzumab Deruxtecan) Antibody, EC50=0.01115 ug/mL.
Hu ErbB2/Her2 mAb [ADC] - (Trastuzumab Deruxtecan)

Flow Cytometry: Hu ErbB2/Her2 mAb [ADC] - (Trastuzumab Deruxtecan) [NBP3-44527] -

SKBR3 cells were stained with ErbB2/Her2 (Trastuzumab Deruxtecan) Antibody and negative control protein respectively, washed and then followed by PE and analyzed with FACS, EC64=0.4164 ug/ml.

Applications for ErbB2/Her2 Antibody [ADC] - (Trastuzumab Deruxtecan, Research Grade)

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Functional

Optimal dilutions of this antibody should be experimentally determined.

Spectra Viewer

Plan Your Experiments

Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.

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Formulation, Preparation, and Storage

Purification

> 90% by SDS-PAGE and HPLC

Reconstitution

Reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

Formulation

Lyophilized from 25mM histidine, 8% sucrose, 0.01% Tween80 (pH6.2)

Preservative

No Preservative

Concentration

LYOPH mg/ml

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C in powder form. Store at -80C once reconstituted.

Background: ErbB2/Her2

ErbB2/HER2 is one of the four members of the ErbB receptor family of transmembrane receptor-like tyrosine kinases (1). The kinase activity of ErbB2 can be activated without ligand if it is overexpressed, and by association with other ErbB proteins (2). Overexpression of ErbB2 is detected in almost 40% of human breast cancers (3). Binding of c-Cbl ubiquitin ligase to Tyr1112 of ErbB2 leads to poly-ubiquitination of ErbB2 and enhances its degradation (4). ErbB2 is one of the major targets for the treatment of breast cancer and other carcinomas.

Long Name

Receptor Tyrosine Protein Kinase ErbB2

Alternate Names

CD340, HER2, Neu Oncogene, NGL, TKR1

Additional ErbB2/Her2 Products

Product Documents for ErbB2/Her2 Antibody [ADC] - (Trastuzumab Deruxtecan, Research Grade)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for ErbB2/Her2 Antibody [ADC] - (Trastuzumab Deruxtecan, Research Grade)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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