CXCL12/SDF-1 beta Antibody [DyLight 650]
Novus Biologicals, part of Bio-Techne | Catalog # AF-351-NAW
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human
Applications
Western Blot, Neutralization
Label
DyLight 650 (Excitation = 652 nm, Emission = 672 nm)
Antibody Source
Polyclonal Goat IgG
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Product Specifications
Immunogen
E. coli-derived recombinant human CXCL12/SDF‑1 beta
Lys22-Met93
Accession # P48061
Lys22-Met93
Accession # P48061
Specificity
Detects human CXCL12/SDF‑1 beta in direct ELISAs and Western blots. Neutralizes 60‑80% of the biological activity of CXCL12/SDF-1 beta and does not neutralize the biological activity of SDF‑1 alpha. In Western blots, less than 5% cross-reactivity with recombinant human SDF-1 alpha is observed.
Clonality
Polyclonal
Host
Goat
Isotype
IgG
Applications for CXCL12/SDF-1 beta Antibody [DyLight 650]
Application
Recommended Usage
Western Blot
Optimal dilutions of this antibody should be experimentally determined.
Neutralization
Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Antigen Affinity-purified
Formulation
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C in the dark.
Background: CXCL12/SDF-1 beta
CXCL12 is a heparin-binding chemokine that regulates lymphopoiesis, enhances the survival of myeloid progenitor cells, regulates the patterning and cell number of neural progenitors, and promotes angiogenesis. CXCL12/SDF-1 beta is one of several SDF-1 isoforms, all of which can undergo proteolytic processing of the first two N-terminal amino acids by DPPIV/CD26. SDF-1 isoforms signal through CXCR4 and CXCR7 and can also bind Syndecan-4. Their binding to CXCR4 may block the cellular entry of HIV.
Alternate Names
SDF1 beta, SDF1b
Gene Symbol
CXCL12
Additional CXCL12/SDF-1 beta Products
Product Documents for CXCL12/SDF-1 beta Antibody [DyLight 650]
Product Specific Notices for CXCL12/SDF-1 beta Antibody [DyLight 650]
DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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