This conjugate is made on demand and is not held in inventory. Each order represents a unique lot. All conjugates are generated using validated conjugation protocols and meet strict degree of labeling (F/P) specifications; additional information is available upon request. The antibody concentration is provided on the individual product label.

For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.

Applications for Cav3.2 Antibody (S55/10) [DyLight 755]

Application

Recommended Usage

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Frozen

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Recommended applications are based on validated applications from the unconjugated base product NBP1-22444. This conjugated antibody is not kept in inventory and is made to order using validated conjugation protocols.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Cav3.2

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inwardrectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). Specifically, Cav3.2 is a protein which in humans is encoded by the CACNA1H gene. Studies suggest certain mutations in this gene lead to childhood absence epilepsy (3, 4). Studies also suggest that the up-regulations of Cav3.2 may participate in the progression of prostate cancer toward an androgen-independent stage (5).

Long Name

Voltage-dependent T-type calcium channel subunit alpha-1H

Alternate Names

CACNA1H, CACNA1HB

Entrez Gene IDs

8912 (Human)

Gene Symbol

CACNA1H

UniProt

O95180 (Human)

Additional Cav3.2 Products

Product Documents for Cav3.2 Antibody (S55/10) [DyLight 755]

Product Datasheets

Download Product Datasheets

COA

SDS

Download SDS

Product Specific Notices for Cav3.2 Antibody (S55/10) [DyLight 755]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations
Reviews

Cav3.2 Antibody (S55/10) [DyLight 755]

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-22444IR

Key Product Details

Species Reactivity

Applications

Label

Antibody Source

Concentration

View all Cav3.2 Antibodies »

Product Specifications

Immunogen

Localization

Specificity

Clonality

Host

Isotype

Description

Applications for Cav3.2 Antibody (S55/10) [DyLight 755]

Immunocytochemistry/ Immunofluorescence

Immunohistochemistry-Frozen

Formulation, Preparation, and Storage

Purification

Formulation

Preservative

Concentration

Shipping

Stability & Storage

Background: Cav3.2

Long Name

Alternate Names

Entrez Gene IDs

Gene Symbol

UniProt

Additional Cav3.2 Products

Product Documents for Cav3.2 Antibody (S55/10) [DyLight 755]

Product Datasheets

COA

Certificate of Analysis

SDS

Product Specific Notices for Cav3.2 Antibody (S55/10) [DyLight 755]