Caspase-2 Antibody [Janelia Fluor® 525]
Novus Biologicals, part of Bio-Techne | Catalog # NBP2-26612JF525
Conjugate
Catalog #
Forumulation
Catalog #
Key Product Details
Species Reactivity
Validated:
Human, Mouse
Predicted:
Rat (94%). Backed by our 100% Guarantee.
Applications
Western Blot, ELISA, Immunocytochemistry/ Immunofluorescence
Label
Janelia Fluor 525
Antibody Source
Polyclonal Rabbit IgG
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Product Specifications
Immunogen
Antibody was raised against a 16 amino acid synthetic peptide from the amino-terminus of human Caspase-2. The immunogen is located within the first 50 amino acids of Caspase-2. Amino Acid Squence: CGMHPHHQETLKKNRV
Specificity
Depending on cell lines or tissues used, other cleavage products may be observed
Clonality
Polyclonal
Host
Rabbit
Isotype
IgG
Applications for Caspase-2 Antibody [Janelia Fluor® 525]
Application
Recommended Usage
ELISA
Optimal dilutions of this antibody should be experimentally determined.
Immunocytochemistry/ Immunofluorescence
Optimal dilutions of this antibody should be experimentally determined.
Western Blot
Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Peptide affinity purified
Formulation
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C in the dark.
Background: Caspase-2
Caspase-2, also known as NEDD2 and ICH-1, is a 30‑32 kDa member of the peptidase C14A/IL‑1 beta‑converting family of enzymes. It is widely expressed and is an integral component of the apoptotic cascade. Caspase-2 is a disulfide-linked homodimer, with activation occurring following oligomerization within the context of activating platforms such as DISC (death-inducing signaling complex) or the PIDDosome. Initially, Pro-Caspase-2 is cleaved into a p34 subunit and a p14 subunit which are further processed to generate the prodomain, plus the mature p18 and p12 subunits. Notably, each p18-p12 heterodimer demonstrates proteolytic activity and localizes to either the nucleus or cytoplasm.
Alternate Names
CASP2, Caspase2, ICH-1, NEDD2
Gene Symbol
CASP2
Additional Caspase-2 Products
Product Documents for Caspase-2 Antibody [Janelia Fluor® 525]
Product Specific Notices for Caspase-2 Antibody [Janelia Fluor® 525]
Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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